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Entry version 82 (22 Apr 2020)
Sequence version 1 (08 Mar 2011)
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Protein
Submitted name:

Cylindromatosis (turban tumor syndrome), a

Gene

cylda

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-168638 NOD1/2 Signaling Pathway
R-DRE-5357786 TNFR1-induced proapoptotic signaling
R-DRE-5357905 Regulation of TNFR1 signaling
R-DRE-5357956 TNFR1-induced NFkappaB signaling pathway
R-DRE-5689880 Ub-specific processing proteases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cylindromatosis (turban tumor syndrome), aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cyldaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-061108-2 cylda

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7FEV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000060058 Expressed in brain and 16 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000078684

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini156 – 194CAP-GlyInterPro annotationAdd BLAST39
Domaini487 – 530CAP-GlyInterPro annotationAdd BLAST44
Domaini587 – 945USPInterPro annotationAdd BLAST359

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni316 – 342DisorderedSequence analysisAdd BLAST27
Regioni375 – 437DisorderedSequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi384 – 432PolarSequence analysisAdd BLAST49

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3556 Eukaryota
ENOG410XP6I LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018123

Database of Orthologous Groups

More...
OrthoDBi
119442at2759

TreeFam database of animal gene trees

More...
TreeFami
TF318734

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.190, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01302 CAP_GLY, 2 hits
PF00443 UCH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01052 CAP_GLY, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit
SSF74924 SSF74924, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50245 CAP_GLY_2, 2 hits
PS00972 USP_1, 1 hit
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E7FEV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSTLWSQEK PGGSFRDDWR FYIVVKECTV ERPGQKTLRI PRGSLGQACQ
60 70 80 90 100
ERNSLGRTIP ASKGKRSLRI LDQTNVVVSV DERDVMELEE KLAELLFPIT
110 120 130 140 150
NCEERYSLLC NRSRLDRARD INCGSKVRVQ LRSGDEPLPG VVRFKGALLP
160 170 180 190 200
DRALSGIWFG VELLEEGRGQ GFTEGSYQGQ QLFRCEDECG VFVALDKLEL
210 220 230 240 250
WEDEELEVDR VTLEDNDPEE EGEAPPLEIN SRVLVQTREG PERGTVIFCD
260 270 280 290 300
LLPGNESLGY YVGVDMDNPI GDWDGIIDGK QLCNFASLEH TRLVPICDVM
310 320 330 340 350
PEYSMQDQRL PKVFACRGGN DKPVSQSKPK SKGLGLQPGS RSKSEFYYTL
360 370 380 390 400
NGSSVDHPAQ SKAKSTWYID EVGEDPAKSL TDMPPDFNPS SSPSRAPPTT
410 420 430 440 450
TSLSNDNKFH SLPFSLSRKV GPNGSMSHGP LSLSAGSVMG EQPELLPAAT
460 470 480 490 500
PLQRASSPPQ GQPGLEVGSM VEVKENPPLC GVIRWVGLPP GLQESLAGLE
510 520 530 540 550
LEEECVGCTD GTFKGIRYFT CPPKKALFVK LKCCRPDSRF PSLHHSPNPI
560 570 580 590 600
ERCNSIAFGG YLSEVVNENT PPRTENDGLE VMVGKKKGIQ GHYNSCYLDS
610 620 630 640 650
TLFCLFSFSS VLDTVLLRPR SKTDVEYYKE TQELLRTEIV NPLRIHGYVC
660 670 680 690 700
ATKIMKLRRI LEKVEAASGF TSEEKDPEEF LNILFHHILR VDPLLRLRSA
710 720 730 740 750
GQKVQDCYFY QIFMDKKDKV MVPTSQQLLE WSFINSDLKF AEAPSCLIIQ
760 770 780 790 800
MPRFGKDFKM FNKIFPSLEL DITDLLDDTP RECRICGGLA LYECRECYED
810 820 830 840 850
YDITPGKIKQ FCEKCNTQVH LHPRRKIHRY VKLSVPKELH ESVWRQGSYP
860 870 880 890 900
HQQMELFAVL CIETSHYVAF VKYGSADSAW LFFDSMADRD GGQNGFNIPQ
910 920 930 940 950
VSRCPEVGEY LKMTPEELHA LDPKNIQGYA RRLLCDAYMC MYQSPTMSLY

K
Length:951
Mass (Da):107,168
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DB97780A55E3201
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W5E2F8W5E2_DANRE
Cylindromatosis (turban tumor syndr...
cylda
912Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CT030153 Genomic DNA No translation available.
CU929130 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_684817.3, XM_679725.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000150229; ENSDARP00000123913; ENSDARG00000060058
ENSDART00000193359; ENSDARP00000154149; ENSDARG00000060058

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
556823

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT030153 Genomic DNA No translation available.
CU929130 Genomic DNA No translation available.
RefSeqiXP_684817.3, XM_679725.6

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WXEX-ray2.50A578-780[»]
A850-951[»]
3WXFX-ray2.30A/C578-780[»]
A/C850-951[»]
3WXGX-ray3.10A/D578-780[»]
A/D850-951[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000078684

Proteomic databases

PaxDbiE7FEV5

Genome annotation databases

EnsembliENSDART00000150229; ENSDARP00000123913; ENSDARG00000060058
ENSDART00000193359; ENSDARP00000154149; ENSDARG00000060058
GeneIDi556823

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
556823
ZFINiZDB-GENE-061108-2 cylda

Phylogenomic databases

eggNOGiKOG3556 Eukaryota
ENOG410XP6I LUCA
GeneTreeiENSGT00390000018123
OrthoDBi119442at2759
TreeFamiTF318734

Enzyme and pathway databases

ReactomeiR-DRE-168638 NOD1/2 Signaling Pathway
R-DRE-5357786 TNFR1-induced proapoptotic signaling
R-DRE-5357905 Regulation of TNFR1 signaling
R-DRE-5357956 TNFR1-induced NFkappaB signaling pathway
R-DRE-5689880 Ub-specific processing proteases

Gene expression databases

BgeeiENSDARG00000060058 Expressed in brain and 16 other tissues

Family and domain databases

Gene3Di2.30.30.190, 3 hits
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF01302 CAP_GLY, 2 hits
PF00443 UCH, 1 hit
SMARTiView protein in SMART
SM01052 CAP_GLY, 3 hits
SUPFAMiSSF54001 SSF54001, 1 hit
SSF74924 SSF74924, 3 hits
PROSITEiView protein in PROSITE
PS50245 CAP_GLY_2, 2 hits
PS00972 USP_1, 1 hit
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7FEV5_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7FEV5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: April 22, 2020
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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