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Protein

WD repeat-containing protein 81

Gene

wdr81

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. May also be involved in maintenance of normal mitochondrial structure and organization.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 81By similarity
Gene namesi
Name:wdr81
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 15

Organism-specific databases

ZFINiZDB-GENE-030131-3389 wdr81

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Lysosome, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004418691 – 2065WD repeat-containing protein 81Add BLAST2065

Proteomic databases

PaxDbiE7FEV0
PeptideAtlasiE7FEV0

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Highly expressed at 5 and 15 hpf. Expression is higher in brain and eye. The expression drops after 72 hpf.1 Publication

Gene expression databases

BgeeiENSDARG00000079702 Expressed in 32 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000100187

Structurei

3D structure databases

ProteinModelPortaliE7FEV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini325 – 617BEACHPROSITE-ProRule annotationAdd BLAST293
Repeati1767 – 1806WD 1Sequence analysisAdd BLAST40
Repeati1813 – 1853WD 2Sequence analysisAdd BLAST41
Repeati1906 – 1945WD 3Sequence analysisAdd BLAST40
Repeati1948 – 1986WD 4Sequence analysisAdd BLAST39
Repeati2035 – 2065WD 5Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1215 – 1292Glu-richPROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the WD repeat WDR81 family.Curated

Keywords - Domaini

Repeat, Transit peptide, WD repeat

Phylogenomic databases

eggNOGiKOG1786 Eukaryota
KOG4190 Eukaryota
ENOG410XR4I LUCA
GeneTreeiENSGT00760000119083
InParanoidiE7FEV0
KOiK17601
OMAiKSVKLYH
OrthoDBiEOG091G00OI
PhylomeDBiE7FEV0
TreeFamiTF323353

Family and domain databases

CDDicd06071 Beach, 1 hit
Gene3Di1.10.1540.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000409 BEACH_dom
IPR036372 BEACH_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF02138 Beach, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM01026 Beach, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81837 SSF81837, 2 hits
PROSITEiView protein in PROSITE
PS50197 BEACH, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

E7FEV0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWLAPALER DLGIDQRQTA HSQRPNELVV LVPTRWVMAL RNKRVTRCAK
60 70 80 90 100
YESFSEGEIC TLLQRSQMKL PSGWTRVCIQ GLRKRKLGYR FARETGCHGE
110 120 130 140 150
GLSQDSFMTL MQGVSQSNFR NLWHEAYMTH VQPYADSVEQ TPVLALDAVR
160 170 180 190 200
QALQKLFCSN FISTDRVSPS LSPAKEKEKD CPFLSTCSAP KQSTESLCPN
210 220 230 240 250
VLPAECLLES EEVLYVVFPY TQYTVHDIVT YSPAKLANSN AKILFILYQL
260 270 280 290 300
LIAMRECHAS GLLCGELSLL DIAVDEQLCS RLKISLAHYE KFKEYRDAVP
310 320 330 340 350
YALQNKVPMS VSTKDNHNNG VSGQLCRNCQ DELKSLVLDW VNGQVSNFQY
360 370 380 390 400
LMELNRLAGR REGDPNYHPV LPWVVDFTVP YGRFRDLKKS KFRLNKGDKQ
410 420 430 440 450
LDFTYEMTKE ALAAVSGSGG SNYPPDLGGP VVPGGPGQSD HLHVPHHISD
460 470 480 490 500
VLSDITYYVY KARQTPKSVL CSHVRSQWEP NEYPASMERI QSWTPDECIP
510 520 530 540 550
EFYRDPSIFR SIHPDMPDLD VPPWCNSYEE FIAVHRQLLE SREVSQQLHH
560 570 580 590 600
WIDLTFGYKL SGKEAIKAKN VCLHLVDNHT HLTSYGVVQL FDHPHPPRLA
610 620 630 640 650
LYQYAPPEPP HFGRVNVTTW QIPPLETTMD GVDGLVPEAT GCESSGWSVV
660 670 680 690 700
GRDEELEQAI EALDLSGSSS STSASVSIPV VGSAAGKTSG ETIGLVVSPS
710 720 730 740 750
HGSFPGEATG NVTNTLGSGI RTAMLHRAAS VSKKPEASNL EDFKISLPDG
760 770 780 790 800
FKPLQPLEEL EKLNTFLVKG LHSEIEHTMD LGINKKDLRS VPKVPLSFTD
810 820 830 840 850
LFQRDMQALG VLIAEIFYSS KLRGLRPETH LRDRFQAVLK LCSTNLRDVP
860 870 880 890 900
LPLHHALDTL LQVHKHCLKT ETIIMHPQGL PFLFKYDPIC EGLPPPNPWQ
910 920 930 940 950
LLSPIVSPLP FPEYFPTLHK FIFSYHSKME SINNIQGRDI VFNLWQQLET
960 970 980 990 1000
LLKGDITTEG LEILLPFVLS LMSEESTAVY AAWYLFEPVS RVLGPRNASK
1010 1020 1030 1040 1050
YLIKPLVGVY ENPRCLRGRF YLYTDCFVLQ LIVRLGLQVF LSSLLPHVLQ
1060 1070 1080 1090 1100
VMTGFESCNT AAGTEWEGMK VLRGAAGALD EEEEEYECDD RRSSNATSSG
1110 1120 1130 1140 1150
KVGGGSGGGS GGVGVVGDQG LVDYSSGISL NDQVFLNEGE DFQNGFYVNN
1160 1170 1180 1190 1200
SASGATTVGT KQQNQSTANK DQDQESLSVG KLSDKSSASE VSIGDRASLK
1210 1220 1230 1240 1250
SADSSQDLKQ ASDGEDGGEL EDEEETVEDR EITVQRVPSL EMTLSVCTEE
1260 1270 1280 1290 1300
SEATVATLEG DVMNGIVQED GEKNMEEEET EHDPLEDSEE KEHKILLDTV
1310 1320 1330 1340 1350
CKTVRWLSAK LGPTLTSRFI ARNLLRLLTS CYIGLDKHQF MLSVNEENSL
1360 1370 1380 1390 1400
ECVGSVYEKK PVVGDQTARP VLECLIYIAH LYGEPVLTYQ YLPYIGYLVS
1410 1420 1430 1440 1450
PPSSCRLNTR KEAGLLGAVV LTQKIIVFLS DTTLMDMLMK INQEVLLPLL
1460 1470 1480 1490 1500
DLLTSTKMGF PSGVQTRSAV CLKTLSLMAL ICLRIGREMV QQHMAETLSR
1510 1520 1530 1540 1550
FFQVFSLLQF LQNQIGSAPR REVAECTYLD LRIPDGAELT IELGVLEELQ
1560 1570 1580 1590 1600
AVFNPEMAYA SYIPFYCLIG DSGIRKLVTN HELVWSLAQS YHERASPGSP
1610 1620 1630 1640 1650
ESNPVGGQRA SAVGLSPSMG RQMSRSPFPA PSSTSTPLGG DILPESGTFG
1660 1670 1680 1690 1700
SHLVGNRIQV TRDTEACGSP NLSSLETWTH GRPYGSNAPP MSLATTALSS
1710 1720 1730 1740 1750
AGPSFSHSSY SWVMGPTPED SALKQDLPRS SRSLQGNWLA YWQYEIGLNQ
1760 1770 1780 1790 1800
QDSHFHFHQI RLQSFIGHSG TAKCLAPLAG EDYFLSGSKD KTVRLWPLYN
1810 1820 1830 1840 1850
HGDGTREVEP RLTYTEHRKS IFYVGQLEAL QEVVSCDGTV HLWDQFTGKN
1860 1870 1880 1890 1900
IRCNEPLDGK NPITAVTTMP APHCSVVFAS ADSVLRFIDP RKPGLQHEFR
1910 1920 1930 1940 1950
LAYSNLSAGL IRCLAVSPGG RTIAAGFSTG FIVLLDARTG LVLRGWPGHE
1960 1970 1980 1990 2000
GDILQMKAAE GNLLVSSSSD HTLTVWKDVE HKPLHQYRTP SDPIHAFDLY
2010 2020 2030 2040 2050
GAEIVAGTVA NKIGVYSILD STASLAGSTK LSTENFRGTL TSLSVLPTKR
2060
LLLLGSDNGA IRLLA
Length:2,065
Mass (Da):228,484
Last modified:March 8, 2011 - v1
Checksum:i5E691A28BD594465
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU861670 Genomic DNA No translation available.
RefSeqiXP_002664681.1, XM_002664635.4
XP_005157714.1, XM_005157657.3
UniGeneiDr.21483

Genome annotation databases

EnsembliENSDART00000156621; ENSDARP00000129633; ENSDARG00000079702
ENSDART00000182609; ENSDARP00000151363; ENSDARG00000079702
GeneIDi100333062
KEGGidre:100333062

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU861670 Genomic DNA No translation available.
RefSeqiXP_002664681.1, XM_002664635.4
XP_005157714.1, XM_005157657.3
UniGeneiDr.21483

3D structure databases

ProteinModelPortaliE7FEV0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000100187

Proteomic databases

PaxDbiE7FEV0
PeptideAtlasiE7FEV0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000156621; ENSDARP00000129633; ENSDARG00000079702
ENSDART00000182609; ENSDARP00000151363; ENSDARG00000079702
GeneIDi100333062
KEGGidre:100333062

Organism-specific databases

CTDi124997
ZFINiZDB-GENE-030131-3389 wdr81

Phylogenomic databases

eggNOGiKOG1786 Eukaryota
KOG4190 Eukaryota
ENOG410XR4I LUCA
GeneTreeiENSGT00760000119083
InParanoidiE7FEV0
KOiK17601
OMAiKSVKLYH
OrthoDBiEOG091G00OI
PhylomeDBiE7FEV0
TreeFamiTF323353

Miscellaneous databases

PROiPR:E7FEV0

Gene expression databases

BgeeiENSDARG00000079702 Expressed in 32 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd06071 Beach, 1 hit
Gene3Di1.10.1540.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000409 BEACH_dom
IPR036372 BEACH_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF02138 Beach, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM01026 Beach, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81837 SSF81837, 2 hits
PROSITEiView protein in PROSITE
PS50197 BEACH, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR81_DANRE
AccessioniPrimary (citable) accession number: E7FEV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2017
Last sequence update: March 8, 2011
Last modified: October 10, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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