UniProtKB - E7FDV1 (E7FDV1_DANRE)
Protein
Submitted name:
EPS8-like 2
Gene
eps8l2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- actin binding Source: GO_Central
GO - Biological processi
- positive regulation of ruffle assembly Source: GO_Central
- regulation of Rho protein signal transduction Source: GO_Central
- Rho protein signal transduction Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: EPS8-like 2Imported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-131121-340, eps8l2 |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: GO_Central
- ruffle membrane Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000058108, Expressed in intestine and 24 other tissues |
ExpressionAtlasi | E7FDV1, baseline |
Interactioni
GO - Molecular functioni
- actin binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000095696 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 146 | PIDInterPro annotationAdd BLAST | 121 | |
Domaini | 436 – 495 | SH3InterPro annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 401 – 435 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 501 – 527 | DisorderedSequence analysisAdd BLAST | 27 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 235 – 255 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 401 – 429 | PolarSequence analysisAdd BLAST | 29 | |
Compositional biasi | 509 – 524 | PolarSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the EPS8 family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, SH3 domainARBA annotationPhylogenomic databases
eggNOGi | KOG3557, Eukaryota |
GeneTreei | ENSGT00940000160990 |
HOGENOMi | CLU_014510_0_0_1 |
OMAi | KEMTLWE |
OrthoDBi | 218804at2759 |
TreeFami | TF313069 |
Family and domain databases
CDDi | cd01210, PTB_EPS8, 1 hit cd11764, SH3_Eps8, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR039801, EPS8-like IPR033928, EPS8_PTB IPR035462, Eps8_SH3 IPR011993, PH-like_dom_sf IPR013625, PTB IPR006020, PTB/PI_dom IPR013761, SAM/pointed_sf IPR041418, SAM_3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR12287, PTHR12287, 1 hit |
Pfami | View protein in Pfam PF08416, PTB, 1 hit PF18016, SAM_3, 1 hit PF00018, SH3_1, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
E7FDV1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVSLFLSEQ RKKYSNSNVI MQETSQYHVQ HLSTFVMDKT EAIATVDDAI
60 70 80 90 100
KKLKLLDSKD KIWTQEMLLQ VTDKSIKLLD CETKEELENF PLATVHHCQT
110 120 130 140 150
LLNQTRYPSV LLLVCQDNEQ HKPDIHFFYC DEVEAEMVHA DIDSALGDNA
160 170 180 190 200
RGKKMRPQTL KLNQEKMKHQ RESIIPPSEP SPGPGVKGRV AATDMKDELS
210 220 230 240 250
MQDPESNMKL AQRIEKDVQI LNCSLDDIEI FVARLHKAAE AFAQLNQRNR
260 270 280 290 300
SKKNKKRGPA EGMLTLRAKP PSEVEFVDCL QKLKLSFNLL AKLKKHIQNP
310 320 330 340 350
NASELIHFLF GPLELILQSS GSPDLPRAVI SPHLSRDAVD FLRGHLTPKE
360 370 380 390 400
MTIFELLGDG WTRPRADWPK DQCAPLYVPK FRNGWEPPVE LFRTSPWETE
410 420 430 440 450
SIGMPKSPVQ SEYRSKEFFG SQSSPSSNGS YPPSPAPRKY AKIRYHFVAR
460 470 480 490 500
NANELSVLQD EILEVLEDGK QWWKLRNRSG QAGYVPYNIL DVIKLEDPQA
510 520 530 540 550
MIDPPYSPSY RGQSPSGSQG SDKDSHLQQM DKVNDELLML ITSNKIHQPT
560 570 580 590 600
RNFKVVRQSA GPLTFESSPA EVTSWLNAKG FSKPTVERLG ILTGAQLFSL
610 620 630 640 650
NKDHLKAVCG DEGSRVYSQI TVQKSQLEKS RGVSELEEIM IRQQEKIKST
K
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketX1WFM8 | X1WFM8_DANRE | EPS8-like 2 | eps8l2 si:ch1073-89b12.1 | 670 | Annotation score: | ||
X1WH12 | X1WH12_DANRE | EPS8-like 2 | eps8l2 si:ch1073-89b12.1 | 210 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU633780 Genomic DNA No translation available. CU694371 Genomic DNA No translation available. CU914534 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000104926; ENSDARP00000095696; ENSDARG00000058108 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU633780 Genomic DNA No translation available. CU694371 Genomic DNA No translation available. CU914534 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000095696 |
Genome annotation databases
Ensembli | ENSDART00000104926; ENSDARP00000095696; ENSDARG00000058108 |
Organism-specific databases
ZFINi | ZDB-GENE-131121-340, eps8l2 |
Phylogenomic databases
eggNOGi | KOG3557, Eukaryota |
GeneTreei | ENSGT00940000160990 |
HOGENOMi | CLU_014510_0_0_1 |
OMAi | KEMTLWE |
OrthoDBi | 218804at2759 |
TreeFami | TF313069 |
Gene expression databases
Bgeei | ENSDARG00000058108, Expressed in intestine and 24 other tissues |
ExpressionAtlasi | E7FDV1, baseline |
Family and domain databases
CDDi | cd01210, PTB_EPS8, 1 hit cd11764, SH3_Eps8, 1 hit |
Gene3Di | 1.10.150.50, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR039801, EPS8-like IPR033928, EPS8_PTB IPR035462, Eps8_SH3 IPR011993, PH-like_dom_sf IPR013625, PTB IPR006020, PTB/PI_dom IPR013761, SAM/pointed_sf IPR041418, SAM_3 IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR12287, PTHR12287, 1 hit |
Pfami | View protein in Pfam PF08416, PTB, 1 hit PF18016, SAM_3, 1 hit PF00018, SH3_1, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7FDV1_DANRE | |
Accessioni | E7FDV1Primary (citable) accession number: E7FDV1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | June 20, 2018 | |
Last modified: | April 7, 2021 | |
This is version 83 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |