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Entry version 75 (07 Oct 2020)
Sequence version 1 (08 Mar 2011)
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Protein

Separase

Gene

espl1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.ARBA annotation EC:3.4.22.49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation
Biological processChromosome partitionARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-2467813, Separation of Sister Chromatids

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C50.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SeparaseARBA annotation (EC:3.4.22.49ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:espl1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-5188, espl1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7FDD8

PeptideAtlas

More...
PeptideAtlasi
E7FDD8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000075354, Expressed in mature ovarian follicle and 23 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000128879

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2007 – 2102Peptidase C50InterPro annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1058 – 1086DisorderedSequence analysisAdd BLAST29
Regioni1294 – 1337DisorderedSequence analysisAdd BLAST44
Regioni1437 – 1561DisorderedSequence analysisAdd BLAST125

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1848 – 1868Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1320 – 1337PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1482 – 1507PolarSequence analysisAdd BLAST26
Compositional biasi1514 – 1534PolarSequence analysisAdd BLAST21
Compositional biasi1546 – 1561PolyampholyteSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1849, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004990

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001558_0_0_1

KEGG Orthology (KO)

More...
KOi
K02365

Identification of Orthologs from Complete Genome Data

More...
OMAi
YSFYSHK

Database of Orthologous Groups

More...
OrthoDBi
14013at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E7FDD8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005314, Peptidase_C50
IPR030397, SEPARIN_core_dom
IPR011990, TPR-like_helical_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12792, PTHR12792, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51700, SEPARIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7FDD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALKSLKTED YVQQLSCVKD TIVLHNELKK HVDGGLGPYG RTMCDRIIRA
60 70 80 90 100
CNQRLGNGAV DAGLQERIVE LVELAVQGFQ LLEESGMQST PFYLEKIVFH
110 120 130 140 150
ILQKVASLGA HGPACRLGQL VYRRLKCLSA EIDDFNVLVR NCFAVLWNSL
160 170 180 190 200
LSNKPSASTL PPRDRLHCQL QALTFRLLEQ GSSSSSSPSK VPLFVEEAVV
210 220 230 240 250
EYERSCGGFT QDDVSFLTSE LRELFSGAFI NPQDSASTSS LLAVWCEVAF
260 270 280 290 300
KVSKLLCKSS FSPEAVELLR GTLKEVNGHV GLRSALGLAD RAVQMQCVLS
310 320 330 340 350
SGGECSKSFT ECARALRMLP CAMSSSESHA LLEACQLVVW TLEASQCKGM
360 370 380 390 400
DVTTLLACFS FLEEYQEFLL AQQKNSFSLQ VQYSLCFSFY QGFICTYDSL
410 420 430 440 450
HASQVSVGET LDRVLLFCRS TAGRMLAELR TLNNDNLLLK AVCAVNNVVY
460 470 480 490 500
ELFNRKLYEG AFGLSMIVCQ ELCKDCPPSL PMDRVNRCFM LTVQCSRRAG
510 520 530 540 550
HLEQALDWIV RWIQALGSQI LDHLTEPVSM WVKTKCDAAR AGEDDTRLRT
560 570 580 590 600
LRDGLGESLV DEEVMMCLLE EELRVYKEQT GDTAQERYNT LCDLLEICHE
610 620 630 640 650
ETPHTLRRAT YLCEMAQVVC YQDFSQQTDC SAVDFTHEAL RLLEAEPETA
660 670 680 690 700
ENTDRLKDEK AHASLWLYIC TLESNLQEAV DTEKRLCAVQ EENKRDVNMD
710 720 730 740 750
PVPTNDLEYE DKQKSQESQL VYDGLRFNLL AHSKQSEPLD KCLSLWRSLL
760 770 780 790 800
KGAVPAVRDP KLTASSMTLM AALYTLMGKH LQALEGYQLA ATLFHVLGDG
810 820 830 840 850
QSSANAFCHS TRILLYLGSP QLAQVDLEKA EKSLSSVTIS EGTSIISMLA
860 870 880 890 900
MLQKAQLHYA LGQVESGVSC LMEVIKESAQ HHSKSWYLLR ARALQTASEY
910 920 930 940 950
LSLDTLALNS QLRQSIMQQG LKTPDTAQYE GLKLLCSLVM MLLGNGFYGA
960 970 980 990 1000
PGPNTDTRFV DKGDSVVFKW LLLSEVLVCS ERMVITRSSS GAVHEAKAQC
1010 1020 1030 1040 1050
LEALKLATKL QTLSHCAELL VLKAELELMK GATEASSLDL EQVRHLLDLC
1060 1070 1080 1090 1100
TDFGQGRQQK SEVKIKPRKG RPAAPSSSGH ISEEEDDLSG ILSSRALPKE
1110 1120 1130 1140 1150
PVENMARLGS QGASPPLKPK CQHGLSCLTH EETCSCLCCT ELSVARVSIH
1160 1170 1180 1190 1200
WALLQADLQT DPERSLRLRQ SARKRCRYVV TKLQRSLAAL VHSKKSPNVC
1210 1220 1230 1240 1250
LSLLQAEQGK VHLGAVLQLL RTGDKGKAAI LWEEIEAGLE AVTPKGALTP
1260 1270 1280 1290 1300
ELGPIRATLL GAKAVACCLA LAMKKQCIPE ELFSSLWHWN PPKVKPQLKS
1310 1320 1330 1340 1350
KHRSKSPDAA PLEAGVKHNP KVKSGLEENE SRKTKETTVI SKKAKDSVPK
1360 1370 1380 1390 1400
ITITKSSMVF KTPKATRTTR PKSVSTSTGI SDLRAFDFNN EVPDISVNFT
1410 1420 1430 1440 1450
PSLHRSTNQS ATAKSKASSK GSFQVYKDSS PAAEKAVVVP AAPKRTKRSR
1460 1470 1480 1490 1500
FKVEFSDESD NDAAPLAVME KSEKKKNTFK TSRTLKPTLN TIPSDTKLVS
1510 1520 1530 1540 1550
STVDPEPSRR TRTTKKSTAL PSIGGLSSEE ELGVSSQTRT RRGRPKKSTS
1560 1570 1580 1590 1600
SADTEEPERM RMIKEEEQRV LLNVSMEELR GSDTETKDTG SPDADCEVLR
1610 1620 1630 1640 1650
RDLGADFGRE CFSELRRAGQ NGSGSHTALP HATTSPADLS VETVQSYLRS
1660 1670 1680 1690 1700
SWLLLHHFPF PSLYPHICSL LAQSFGQTDP IITAMLHAQA LGVSTRHHMT
1710 1720 1730 1740 1750
RHVVNQFRKL KKSCNDVAEG LGALSLEETS GATQSKKLSA LEQIFSFTAS
1760 1770 1780 1790 1800
NPMQFPQTHC QQFTQQLEDL PAGVTVCLLS LTGVHPDEIG NTILLTRLER
1810 1820 1830 1840 1850
GSTPITVRIP TADREQSVAG LLEEMDGVLK GQKEVSTVAE KSQWWDGRKA
1860 1870 1880 1890 1900
LDARVEKMLE EMEEALGVWR TLFLPLTSDP KLDVQVKSLQ KALKSTKITR
1910 1920 1930 1940 1950
DTLKVILSAS PLLSLPDLQC LLEGMNVQDK DLLKLLQRGV AELRGREEPQ
1960 1970 1980 1990 2000
GHTVLILDKY LQRLPWENIA CLKSQSVTRM PSLHAVLGHS HLREVDTSCV
2010 2020 2030 2040 2050
LSCGVNPKQV YYVLNPDGNL PDTENRFKEW FTGERTWQGV CGRAPDPEKL
2060 2070 2080 2090 2100
QEAVTTKDLY IYIGHGAGAR FLDAQRVLKV PVRTAALLFG CSSAALSVLG
2110 2120 2130 2140 2150
QQEGTGIILS YLTAGCPLVL GNLWDVTDRD LDRFTSALLQ SWLSAGSGSS
2160 2170 2180
LLQHLAKSRS ATHLKHIIGA APIAYGLPVH IH
Length:2,182
Mass (Da):240,857
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i687BC2C1AD561AF6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL954698 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_001337869.1, XM_001337833.4
XP_017212151.1, XM_017356662.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000156645; ENSDARP00000128879; ENSDARG00000075354

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
797406

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:797406

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954698 Genomic DNA No translation available.
RefSeqiXP_001337869.1, XM_001337833.4
XP_017212151.1, XM_017356662.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000128879

Protein family/group databases

MEROPSiC50.002

Proteomic databases

PaxDbiE7FDD8
PeptideAtlasiE7FDD8

Genome annotation databases

EnsembliENSDART00000156645; ENSDARP00000128879; ENSDARG00000075354
GeneIDi797406
KEGGidre:797406

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9700
ZFINiZDB-GENE-030131-5188, espl1

Phylogenomic databases

eggNOGiKOG1849, Eukaryota
GeneTreeiENSGT00390000004990
HOGENOMiCLU_001558_0_0_1
KOiK02365
OMAiYSFYSHK
OrthoDBi14013at2759
PhylomeDBiE7FDD8

Enzyme and pathway databases

ReactomeiR-DRE-2467813, Separation of Sister Chromatids

Gene expression databases

BgeeiENSDARG00000075354, Expressed in mature ovarian follicle and 23 other tissues

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR005314, Peptidase_C50
IPR030397, SEPARIN_core_dom
IPR011990, TPR-like_helical_dom_sf
PANTHERiPTHR12792, PTHR12792, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS51700, SEPARIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7FDD8_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7FDD8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: October 7, 2020
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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