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Entry version 71 (07 Apr 2021)
Sequence version 3 (20 Jun 2018)
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Protein
Submitted name:

Zgc:165453

Gene

zgc:165453

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitorARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zgc:165453Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:zgc:165453Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070720-13, zgc:165453

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7FCS3

PeptideAtlas

More...
PeptideAtlasi
E7FCS3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000078183, Expressed in female gonad and 22 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000017776

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini431 – 579A2M_N_2InterPro annotationAdd BLAST149
Domaini705 – 794A2MInterPro annotationAdd BLAST90
Domaini1316 – 1405A2M_recepInterPro annotationAdd BLAST90

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]ARBA annotation

Keywords - Domaini

SignalARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1366, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162996

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E7FCS3

TreeFam database of animal gene trees

More...
TreeFami
TF313285

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02897, A2M_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR041813, A2M_TED
IPR011626, Alpha-macroglobulin_TED
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR008930, Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF07678, TED_complement, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7FCS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LFLVTFPSLI ESDTEAKLCA SLLKPKGSVT MTISLVDEKS TEIQLVQQTS
60 70 80 90 100
GRKFHRCFHF QAPQVSGDSV QTVRVVIQGQ SFKMTEESKV MFRSYLPLTF
110 120 130 140 150
IQTDKPLYNP GQRVNFRVLT MSDTFVPQDQ MYSLVVVEDN NKIRIRQWTD
160 170 180 190 200
ISSTNWILEL SHVLDKEAQV GTYTLKAYIG DRTISQSFDV KKYVLPKFDM
210 220 230 240 250
TLNTPQTYNV ADVGLKVEAC AKYTYGQPVP GQVSVNLCRQ HFTFIQDPKV
260 270 280 290 300
TICLNETALM DDTGCTSLTF STSTFFGTSL ESSLQNSFVV NVNLTEQGTD
310 320 330 340 350
VVMSKSATVS ITYEVGKVTF VDLPKFYDYG STINAKAMSD FNGNAISNKV
360 370 380 390 400
VYLLDHGQWR PKVLFNVTTD ESGLAEFSLN TTNFPKANLY LVASVIPQLW
410 420 430 440 450
FNDNSPHFTT DSQVVQLSQT AAPDNPTYSD LSIVSLQQPL KCGTTYPVTV
460 470 480 490 500
KYTFVGETGD YSADIIYMVM SRGVIVLHGF KTVQAWASDT LTTGTVTFDL
510 520 530 540 550
PVHAKMAPMV QILVFSVLPS ETVVTGSASF DTEKCFSNQV SLQFSPATAV
560 570 580 590 600
PGEGSILTVS AQAGSLCGLS AIDQSVLIMQ SGGRLSAEAM FNLLPVRSLS
610 620 630 640 650
DYPPGVEDQQ NCLNVRPLRD VPTDQAYNTF KGVGIKTATN LPVREPPCLT
660 670 680 690 700
YRGLSYYRNF PGVLYSPVES SDLVLNAPVP VELGELVRGD SGSSAVTIRT
710 720 730 740 750
YFPETWIWQL VTVGDSGSTS VPLTVPDTIT AWDTEAFCLA SSGFGLAPPV
760 770 780 790 800
LLTSFQPFFL EITLPYSIIR GEILNLKATV FNYLPQCIKV QVTPTPSSNF
810 820 830 840 850
TLKSFGHYSS HLSANGRKTF KWDLTASVIG TINVTISAQA SPSEQLCDNQ
860 870 880 890 900
LVTVPSRGHT DIVTRSLLVL AEGVERTFIR NWLLCPKGYI LSESVKITFP
910 920 930 940 950
TKVIQGSARC SVSAIGDIMG RALKNLANLL QMPYGCGEQN MIILAPNIYT
960 970 980 990 1000
LQYLKVTAQL TPAIQDTAAS YLLSGYQREL NYRHSDGSFS TFPYSPSNTW
1010 1020 1030 1040 1050
LTTFVMRTFG LARNFTYIDP NVLQSAKDWL IGTQGSDGCF VQQGTLYHKD
1060 1070 1080 1090 1100
MKGGVDDNVT MTGYIVASML EIGVPVTDPV ITKALSFLRP LVGNLGNTYV
1110 1120 1130 1140 1150
TALLAYTFSL AGETSTRAQL LNSLRNTAIS EGTTLHWSQT TSGDTLAVEI
1160 1170 1180 1190 1200
SAYVLLAVLT VQPVTTANLG YANRIVNWLV AQQNPYGGFS STQDTVVALQ
1210 1220 1230 1240 1250
ALSMYAAQVF SPGGSSTVTV QSSVPAGDVF NFDVTPNNRL LYQESPLNNF
1260 1270 1280 1290 1300
PGTYSVVAAG AACASVQVLC FYNIPTPVRV SKTLSVVAKV SGNCQATPVN
1310 1320 1330 1340 1350
LMLTFTAKYT GPKPTTNMVL VDIKLLSGFT ADTSLLGSPP NFAPLVQRVD
1360 1370 1380 1390 1400
SEGDHVLIYL QEVPKGVPVT FSIQLTQTVA VQNLKPAVIN IYDYYQRSDS
1410
FETAYKSPCP
Length:1,410
Mass (Da):153,936
Last modified:June 20, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC64FCAF1CBD8C80E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CABZ01040995 Genomic DNA No translation available.
CABZ01040996 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000024900; ENSDARP00000017776; ENSDARG00000078183

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01040995 Genomic DNA No translation available.
CABZ01040996 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000017776

Proteomic databases

PaxDbiE7FCS3
PeptideAtlasiE7FCS3

Genome annotation databases

EnsembliENSDART00000024900; ENSDARP00000017776; ENSDARG00000078183

Organism-specific databases

ZFINiZDB-GENE-070720-13, zgc:165453

Phylogenomic databases

eggNOGiKOG1366, Eukaryota
GeneTreeiENSGT00940000162996
InParanoidiE7FCS3
TreeFamiTF313285

Gene expression databases

BgeeiENSDARG00000078183, Expressed in female gonad and 22 other tissues

Family and domain databases

CDDicd02897, A2M_2, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR041813, A2M_TED
IPR011626, Alpha-macroglobulin_TED
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR008930, Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF07678, TED_complement, 1 hit
SMARTiView protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit
SUPFAMiSSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7FCS3_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7FCS3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: June 20, 2018
Last modified: April 7, 2021
This is version 71 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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