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UniProtKB - E7FC95 (E7FC95_DANRE)
Protein
Dynamin GTPase
Gene
dnm1b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalytic activityi
- EC:3.6.5.5ARBA annotation
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
- microtubule binding Source: GO_Central
GO - Biological processi
- receptor internalization Source: GO_Central
- synaptic vesicle endocytosis Source: GO_Central
Keywordsi
Molecular function | HydrolaseARBA annotation, Motor proteinARBA annotation |
Biological process | EndocytosisARBA annotation |
Ligand | GTP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:dnm1bImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-100920-3, dnm1b |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Cytoskeleton
- microtubule Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- membrane Source: GO_Central
- presynapse Source: GOC
- synapse Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, CytoskeletonARBA annotation, MicrotubuleARBA annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000009281, Expressed in brain and 16 other tissues |
ExpressionAtlasi | E7FC95, baseline |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 294 | Dynamin-type GInterPro annotationAdd BLAST | 267 | |
Domaini | 519 – 625 | PHInterPro annotationAdd BLAST | 107 | |
Domaini | 659 – 750 | GEDInterPro annotationAdd BLAST | 92 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 631 – 650 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 752 – 858 | DisorderedSequence analysisAdd BLAST | 107 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 780 – 841 | Pro residuesSequence analysisAdd BLAST | 62 | |
Compositional biasi | 842 – 858 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000155214 |
OrthoDBi | 264244at2759 |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027741, DNM1 IPR022812, Dynamin IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR045063, Dynamin_N IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR11566, PTHR11566, 1 hit PTHR11566:SF32, PTHR11566:SF32, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit PF00169, PH, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit PS50003, PH_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
E7FC95-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNRGMEDLI PLVNRMQDAF SAIGQNANLD LPQIAVVGGQ SAGKSSVLEN
60 70 80 90 100
FVGKDFLPRG SGIVTRRPLV LQLINCPTEY AEFLHCKGKK FTDFDEVRQE
110 120 130 140 150
IEAETDRITG QNKGISPVPI NLRVYSPNVL NLTLVDLPGM TKVPVGDQPA
160 170 180 190 200
DIEAQIRDML MQFVTKENCL LLAVSPANSD LANSDALKIA KEVDPQGMRT
210 220 230 240 250
IGVITKLDLM DEGTDAREIL ENKLLPLRRG YIGVVNRSQK DIDGKKDITA
260 270 280 290 300
AMSAERKFFL THPSYRHLAD RMGTPYLQKA LNQQLTNHIR DTLPGLRNKL
310 320 330 340 350
QSQLLSIEKE VEEYKHFRPD DPSRKTKALL QMVQQFAVDF EKCIEGSGDQ
360 370 380 390 400
VDTVELSGGA RINRIFHERF PFELVKMEFD EKELRKEISY AIKNIHGIRT
410 420 430 440 450
GLFTPDMAFE TIVKRQIAKI KEPCQKCVDL VITELVNTVR QCTKKLAQYP
460 470 480 490 500
MLREEMERIV TQHIRDRESR TKNQVMLLID IELAYMNTNH EDFIGFANAQ
510 520 530 540 550
QRSSQMNKKK AAGNQDEIMV IRKGWLTINN IGIMKGGAKE YWFVMTAENL
560 570 580 590 600
SWYKDDEEKE KKYMLPLDNL KLRDIEKSFM SSKHVFALFN TEQRNVYKDY
610 620 630 640 650
RQLELASDTQ EEVDSWKASF LRAGVYPERI TDKEKSDTSD ESSSDGFMHS
660 670 680 690 700
MDPQLERQVE TIRNLVDSYM AIVNKTVRDL MPKTIMHLMI NNTKDFIHAE
710 720 730 740 750
LLANLYSCGD QNTLMEESAE QAQHREEMLR MYHALKEALN IIGDISTSTV
760 770 780 790 800
STAMPPPVDD SWLQVQGGPS GRRSPMSSPT PQRRAPPGPP RPGGRTAPGP
810 820 830 840 850
PTIGAPPVPS RPGASPDPFG APPPQVPSRP NRAPPGVPSR PSKGSPSHSE
SPQPSFDS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9QF63 | E9QF63_DANRE | Dynamin GTPase | dnm1b | 846 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU856222 Genomic DNA No translation available. CU929237 Genomic DNA No translation available. |
RefSeqi | NP_001243747.1, NM_001256818.1 |
Genome annotation databases
Ensembli | ENSDART00000097330; ENSDARP00000088100; ENSDARG00000009281 |
GeneIDi | 100333543 |
KEGGi | dre:100333543 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU856222 Genomic DNA No translation available. CU929237 Genomic DNA No translation available. |
RefSeqi | NP_001243747.1, NM_001256818.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | E7FC95 |
Genome annotation databases
Ensembli | ENSDART00000097330; ENSDARP00000088100; ENSDARG00000009281 |
GeneIDi | 100333543 |
KEGGi | dre:100333543 |
Organism-specific databases
CTDi | 100333543 |
ZFINi | ZDB-GENE-100920-3, dnm1b |
Phylogenomic databases
GeneTreei | ENSGT00940000155214 |
OrthoDBi | 264244at2759 |
Gene expression databases
Bgeei | ENSDARG00000009281, Expressed in brain and 16 other tissues |
ExpressionAtlasi | E7FC95, baseline |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027741, DNM1 IPR022812, Dynamin IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR045063, Dynamin_N IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR11566, PTHR11566, 1 hit PTHR11566:SF32, PTHR11566:SF32, 1 hit |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit PF00169, PH, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit PS50003, PH_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E7FC95_DANRE | |
Accessioni | E7FC95Primary (citable) accession number: E7FC95 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | January 20, 2016 | |
Last modified: | January 19, 2022 | |
This is version 86 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |