UniProtKB - E7FB98 (UBIA1_DANRE)
Protein
UbiA prenyltransferase domain-containing protein 1
Gene
ubiad1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from nos3/eNOS-dependent oxidative stress.2 Publications
: menaquinone biosynthesis Pathwayi
This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.
Pathwayi: ubiquinone biosynthesis
This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.
GO - Molecular functioni
- antioxidant activity Source: UniProtKB
- nitric-oxide synthase activity Source: ZFIN
- prenyltransferase activity Source: UniProtKB
GO - Biological processi
- cellular response to fluid shear stress Source: ZFIN
- circulatory system development Source: UniProtKB
- endothelial cell development Source: UniProtKB
- menaquinone biosynthetic process Source: UniProtKB
- ubiquinone biosynthetic process Source: UniProtKB
- ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate Source: ZFIN
- vitamin K biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Prenyltransferase, Transferase |
Biological process | Menaquinone biosynthesis, Ubiquinone biosynthesis |
Enzyme and pathway databases
Reactomei | R-DRE-6806664, Metabolism of vitamin K |
UniPathwayi | UPA00079 UPA00232 |
Names & Taxonomyi
Protein namesi | Recommended name: UbiA prenyltransferase domain-containing protein 1 (EC:2.5.1.-)Alternative name(s): Protein barolo Protein reddish |
Gene namesi | Name:ubiad1 Synonyms:bar, reh |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030131-3205, ubiad1 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: ZFIN
- integral component of Golgi membrane Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 79 – 99 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 180 – 200 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 254 – 274 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 315 – 335 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, Membrane, MitochondrionPathology & Biotechi
Disruption phenotypei
Cranial vascular hemorrhages and pericardial edema, leading to complete cardiac and vascular organ failure by 72 hpf. Defects are due to increased oxidative stress.2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 65 | L → Q in reh(S587); cranial vascular hemmorhages in multiple areas of the head, leading to death by 72 hpf. 1 Publication | 1 | |
Mutagenesisi | 82 | L → Q in bar(S847); increased oxidative stress, DNA damage and cell death specifically in blood vessels and the heart. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000422598 | 1 – 336 | UbiA prenyltransferase domain-containing protein 1Add BLAST | 336 |
Proteomic databases
PaxDbi | E7FB98 |
Expressioni
Developmental stagei
Ubiquitous expression at 24 hours post fertilization (hpf) in addition to a distinct expression in the heart at 48 hpf.1 Publication
Gene expression databases
Bgeei | ENSDARG00000013009, Expressed in retina and 30 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the UbiA prenyltransferase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4581, Eukaryota |
GeneTreei | ENSGT00390000012439 |
HOGENOMi | CLU_043611_0_0_1 |
InParanoidi | E7FB98 |
OMAi | PMAFPLE |
OrthoDBi | 1146311at2759 |
PhylomeDBi | E7FB98 |
TreeFami | TF323238 |
Family and domain databases
CDDi | cd13962, PT_UbiA_UBIAD1, 1 hit |
InterProi | View protein in InterPro IPR000537, UbiA_prenyltransferase IPR026046, UBIAD1 |
Pfami | View protein in Pfam PF01040, UbiA, 1 hit |
PIRSFi | PIRSF005355, UBIAD1, 1 hit |
i Sequence
Sequence statusi: Complete.
E7FB98-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQEMKPAALS GSNGLNGASG SSVRVPCSRL SRAGRMALDL QSKCAAYVLA
60 70 80 90 100
LRPWSFSASL TPVALGSALA YKLEGSVDLL LLLVCAVAVL LVHGAGNLVN
110 120 130 140 150
TYYDFSKGID HKKSDDRTLV DQILKPQDVV MFGAVLYSAG CLCATLLYFL
160 170 180 190 200
SSLKLEHLAL IYFGGLSSSF LYTGGIGLKY VALGDVVILI TFGPLAVMFA
210 220 230 240 250
HAVQVGYLSV LPLVYAVPLA LNTEAILHSN NTRDMDSDKQ AGIVTLAILL
260 270 280 290 300
GPTLSYVIYN LLLFVPYLLF CILATRYTIS MALPLLTLPM AFPLERQFRC
310 320 330
RCYAKIPQKT AKLNLLMGLF YVFGIILAPQ GSLPLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABZ01068151 Genomic DNA No translation available. |
RefSeqi | NP_001186655.1, NM_001199726.3 |
Genome annotation databases
Ensembli | ENSDART00000015554; ENSDARP00000012519; ENSDARG00000013009 |
GeneIDi | 558410 |
KEGGi | dre:558410 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABZ01068151 Genomic DNA No translation available. |
RefSeqi | NP_001186655.1, NM_001199726.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000012519 |
Proteomic databases
PaxDbi | E7FB98 |
Genome annotation databases
Ensembli | ENSDART00000015554; ENSDARP00000012519; ENSDARG00000013009 |
GeneIDi | 558410 |
KEGGi | dre:558410 |
Organism-specific databases
CTDi | 29914 |
ZFINi | ZDB-GENE-030131-3205, ubiad1 |
Phylogenomic databases
eggNOGi | KOG4581, Eukaryota |
GeneTreei | ENSGT00390000012439 |
HOGENOMi | CLU_043611_0_0_1 |
InParanoidi | E7FB98 |
OMAi | PMAFPLE |
OrthoDBi | 1146311at2759 |
PhylomeDBi | E7FB98 |
TreeFami | TF323238 |
Enzyme and pathway databases
UniPathwayi | UPA00079 UPA00232 |
Reactomei | R-DRE-6806664, Metabolism of vitamin K |
Miscellaneous databases
PROi | PR:E7FB98 |
Gene expression databases
Bgeei | ENSDARG00000013009, Expressed in retina and 30 other tissues |
Family and domain databases
CDDi | cd13962, PT_UbiA_UBIAD1, 1 hit |
InterProi | View protein in InterPro IPR000537, UbiA_prenyltransferase IPR026046, UBIAD1 |
Pfami | View protein in Pfam PF01040, UbiA, 1 hit |
PIRSFi | PIRSF005355, UBIAD1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBIA1_DANRE | |
Accessioni | E7FB98Primary (citable) accession number: E7FB98 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2013 |
Last sequence update: | March 8, 2011 | |
Last modified: | February 10, 2021 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families