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Entry version 74 (11 Dec 2019)
Sequence version 3 (20 Jun 2018)
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Protein
Submitted name:

von Willebrand factor

Gene

vwf

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-114608 Platelet degranulation
R-DRE-140837 Intrinsic Pathway of Fibrin Clot Formation
R-DRE-216083 Integrin cell surface interactions
R-DRE-354192 Integrin alphaIIb beta3 signaling
R-DRE-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-DRE-372708 p130Cas linkage to MAPK signaling for integrins
R-DRE-430116 GP1b-IX-V activation signalling
R-DRE-5674135 MAP2K and MAPK activation
R-DRE-75892 Platelet Adhesion to exposed collagen
R-DRE-76009 Platelet Aggregation (Plug Formation)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
von Willebrand factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vwfImported
Synonyms:VWFImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070103-1 vwf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

SecretedSAAS annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502252851926 – 2812Sequence analysisAdd BLAST2787

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2722 ↔ 2772PROSITE-ProRule annotation
Disulfide bondi2737 ↔ 2786PROSITE-ProRule annotation
Disulfide bondi2748 ↔ 2802PROSITE-ProRule annotation
Disulfide bondi2752 ↔ 2804PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7F9Z1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000077231 Expressed in 19 organ(s), highest expression level in heart

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000101847

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 233VWFDInterPro annotationAdd BLAST206
Domaini380 – 591VWFDInterPro annotationAdd BLAST212
Domaini857 – 1060VWFDInterPro annotationAdd BLAST204
Domaini1257 – 1430VWFAInterPro annotationAdd BLAST174
Domaini1494 – 1661VWFAInterPro annotationAdd BLAST168
Domaini1693 – 1871VWFAInterPro annotationAdd BLAST179
Domaini1950 – 2148VWFDInterPro annotationAdd BLAST199
Domaini2266 – 2338VWFCInterPro annotationAdd BLAST73
Domaini2438 – 2504VWFCInterPro annotationAdd BLAST67
Domaini2581 – 2643VWFCInterPro annotationAdd BLAST63
Domaini2722 – 2810CTCKInterPro annotationAdd BLAST89

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR8A Eukaryota
ENOG41100RZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155810

KEGG Orthology (KO)

More...
KOi
K03900

Database of Orthologous Groups

More...
OrthoDBi
12226at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300299

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006207 Cys_knot_C
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR037578 Von_Willebrand_factor
IPR002035 VWF_A
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11339:SF361 PTHR11339:SF361, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08742 C8, 4 hits
PF01826 TIL, 3 hits
PF00092 VWA, 3 hits
PF00094 VWD, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00327 VWA, 3 hits
SM00214 VWC, 3 hits
SM00215 VWC_out, 2 hits
SM00216 VWD, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300 SSF53300, 3 hits
SSF57567 SSF57567, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS50234 VWFA, 3 hits
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 3 hits
PS51233 VWFD, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E7F9Z1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEACKWSRIM WIVILNLSDL LLVEGSARCS LFSRQHIHTF DGVIYEFPGD
60 70 80 90 100
CSYMLAGDCR QRSFSILGDF SHGKRKGVTV FLGEMFELHL SVDGTLSQGA
110 120 130 140 150
ERLPLPYASS SVFAGYELGY VRLWSEEFGF SIRIDPLHNI QLTLEKRHSN
160 170 180 190 200
QTCGLCGNYN YLAEDEYSAQ EGFLTDDPYD FANSWAMKGA DEPCKRVLPP
210 220 230 240 250
SQSCNSTGES TKDQMSACES MRSSVLFMHC AHLVDPAAFV SVCESDVCHC
260 270 280 290 300
SAGKECVCQA MLEYSRACAS RGITLSNWHT QSQCSPKCPV GMEYSDCTPT
310 320 330 340 350
CSTSCQNVNI QEVCKEECVD GCICPAGKVL DGDRCVDVSQ CSCTHAGRRY
360 370 380 390 400
PPASYISQDC NTCVCRHGSW ECTNEGCPGE CLVTGQSHYK TFDNKFFTFS
410 420 430 440 450
GICHYLLAKD CQSNSFSAVI ETAQCADDQD AICTRSITLR FKDLANQTVH
460 470 480 490 500
LKHGGVVSVD GMDVQTPLIN GPLRIQNTVL SSVRLRYGHD LHLDWDGRGR
510 520 530 540 550
VLLRLKPAYA GQMCGLCGNY NGNQGDDFLT VGGLVETRVE AFGNSWKMNA
560 570 580 590 600
DCDDVQMQNS DPCSLNPKRV RFAEEACAVL LSMKFEPCHY MVNPEPYVKN
610 620 630 640 650
CRYDVCACAD GQECLCDAVS SYAVACAARG VLVNWRSHGY CELTCPDAQV
660 670 680 690 700
YEMCGSVCNQ TCRSLSLPDT GCDGVCEEGC FCPRGLFLSD AGECVPPQHC
710 720 730 740 750
SCHHNGEIFE PNDMIGDHHS ICVCESGSMH CTSNEATGST LSDLFFDEQS
760 770 780 790 800
PSRGRRSLSC PPPLQRFECE SARDAGIECA KTCQNLELDC VSLGCVSGCM
810 820 830 840 850
CPPGTVRYRK DCIPQEQCPC YHNSRPYESG QSITVDCNTC VCEQRQWKCS
860 870 880 890 900
ERVCDGVCRA IGDTHYISFD GLKFSFPGPC QYVLAQDYCN GLDGTFRVLV
910 920 930 940 950
ENSACGIAGY RCSKSITVLY MGGLIVMEHG EVRMKRPVLK ETEVEIVRSG
960 970 980 990 1000
LYYIVLLGKH ISITWDTGTR ISLQISGQYR GKVCGLCGNF DGSQNNDLLS
1010 1020 1030 1040 1050
SSNQMEVDAA DFGNSWKVRP SCADAVSVVS QCSTDLVKLV TVEQSCRVLT
1060 1070 1080 1090 1100
SAIFRDCNSV VDPEPYWDIC TQDTCSCPSV GDCACFCNTI AAYAHECAQK
1110 1120 1130 1140 1150
GLPVNWRSND LCPLSCEDLN KESGVQCEWR YNTCASACPS TCQHPEPLSC
1160 1170 1180 1190 1200
PISCVEGCHA VCPPGHLLDE VLRKCVEPSQ CQVCVHDGQR VSHGKQFILN
1210 1220 1230 1240 1250
HEDPRLCQIC HCESNTLTCG PCPVTGLTST LAPTTVTPTP LPFSTPVPAD
1260 1270 1280 1290 1300
ACDRAMDLAF LVDGSSALSE DDFSMIKLFI LRVVERFRMG SAHTRATVLL
1310 1320 1330 1340 1350
FHSGVKSYDM QVQKWIFKKM VREMRYTGGD VAFMDEAIKY LAVYIYDKNK
1360 1370 1380 1390 1400
REHAGRVAIL LTASANPRPM RSTQRLLRKK DITILTVALG PDVNMAQVNE
1410 1420 1430 1440 1450
ITKATPSSRA YVVSSVTELD DEALSITDYL CTLGLDPEPQ KKPPTAKPST
1460 1470 1480 1490 1500
TSVTPTTNAI TKLTIPPTAA IVTAFPSIPT PGTTLVPTTV TTYDLVFLLE
1510 1520 1530 1540 1550
NANATGEDGF NKTRDSLINI ITSLDQKEAE NLRITVMMYS VTVTVEISRM
1560 1570 1580 1590 1600
ELHHREQVVQ RMRQLRWTEG AEVNTGHAVQ SVYETITTDT HSDTPDQLVF
1610 1620 1630 1640 1650
LITQSPPTDV IQRPPSSTHK KIYPIGIGRK IRYEDLALLS FPDKPIMLDD
1660 1670 1680 1690 1700
PSDLRTLQPM LINISRTVRR PLLPTLPPRA TLPPSVPCSK PMDVLFLLRA
1710 1720 1730 1740 1750
SSGSQFEDLK TFVKTFIKST NIGRNDTQVA VMVYGAKSAV AVTWRDEQTQ
1760 1770 1780 1790 1800
DNLLKLLESL HGKTDNQPRL GAALRLAVQT AVSSTSGARM GIPKAVVMVV
1810 1820 1830 1840 1850
TDRSIDSVQE AANEALTAGV SVFPIGLGKQ YDQIEVNTLA GPQAQENVIL
1860 1870 1880 1890 1900
LGSTEYLLSM AAFDQSFPDK LCRAGPPGVC VDDEGNERKP GETWMLADGC
1910 1920 1930 1940 1950
HSVLCNPSGT ITMQSHRINC EKMEPPVCKN NLPALRYNHH CGCTWTCPCS
1960 1970 1980 1990 2000
CMGSSTSHVV SFSGAALKVK SACSYLLLRS GGAELVLHTT ACQSSPNQIC
2010 2020 2030 2040 2050
MKSLELREGG TSVVLQDDMK VTVGGVLTAV PFRTERVTVT QIGSILHQLR
2060 2070 2080 2090 2100
SEQHGFTLTF TPHSNEFMLN MDIAMKPNTT GLCGSCSDDQ SGLLLSDGSV
2110 2120 2130 2140 2150
TTDPDVYLQA WALGSECVQH QEIQLCPAGL EKACDVLSSE VFSHCHALVP
2160 2170 2180 2190 2200
VQDYIQICRS VACQPNALCD LVTAYSTVCR QQGVCVDWRT SSLCPMSCSD
2210 2220 2230 2240 2250
SMEYAACRSG CLEQCGQSQF TPGDMMGDGL LKANGSVCLN TPTEGCFCPE
2260 2270 2280 2290 2300
GSVLMEDKCV DREACSQCVE HSGKTHQFME SWNPEDNPCV LCVCLDQQRI
2310 2320 2330 2340 2350
NCTALPCTNA KAPECGQCEV LQEKMGSKCC PQYECVCDIN CKRPDPPHCD
2360 2370 2380 2390 2400
HGLSVVLTNP GDCLPVYQCV CKKDQCPDST KPSCPAYKKL SVKASECCDS
2410 2420 2430 2440 2450
YQCLCNCQNI TRTCPPGYIT KTSTNDCQCT EVTCTPDKVC VVDAVVYQVG
2460 2470 2480 2490 2500
SRWEEKCKTC RCTEQTDGQT GLHIAQCVDP VCNQICPVGS TYSHSGGECC
2510 2520 2530 2540 2550
GHCRKSSCEE GGLLRQVGEQ WVSANDRCVW SECVQVNEEV FIQHTNVSCH
2560 2570 2580 2590 2600
HMDTPACPLG TELQCNTVDD CCPSCHCVPM NACVLNQTVI AAGERVMLDV
2610 2620 2630 2640 2650
CTHCECVGDK RSYRLSCRKM SCSPCSEGYT MEPIPNACCG RCVATACSVR
2660 2670 2680 2690 2700
RPDGELITLK ANTTRTDGCT KHTCSVNKDE ELVLETLVTT CPPFDRKSCL
2710 2720 2730 2740 2750
EHGGKISQIG DTCCNMCTEP ECRRTVGLLN YIRVDDCQSE EKIELTYCEG
2760 2770 2780 2790 2800
KCGSKSVYSL EKHKVENECV CCSATGTVPM NVSLRCANGT QTHHQVLAVT
2810
GCDCMSHTCS ND
Length:2,812
Mass (Da):307,761
Last modified:June 20, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF567D0D50E40066F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QHS6F1QHS6_DANRE
von Willebrand factor
vwf
2,059Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1R1J2F1R1J2_DANRE
von Willebrand factor
vwf
444Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU651594 Genomic DNA No translation available.
CU651633 Genomic DNA No translation available.
CU929302 Genomic DNA No translation available.
LO018341 Genomic DNA No translation available.
BK007984 mRNA Translation: DAA34800.1

NCBI Reference Sequences

More...
RefSeqi
NP_001268918.1, NM_001281989.1
XP_002665356.3, XM_002665310.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000114690; ENSDARP00000101847; ENSDARG00000077231

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
570643

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:570643

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU651594 Genomic DNA No translation available.
CU651633 Genomic DNA No translation available.
CU929302 Genomic DNA No translation available.
LO018341 Genomic DNA No translation available.
BK007984 mRNA Translation: DAA34800.1
RefSeqiNP_001268918.1, NM_001281989.1
XP_002665356.3, XM_002665310.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000101847

Proteomic databases

PaxDbiE7F9Z1

Genome annotation databases

EnsembliENSDART00000114690; ENSDARP00000101847; ENSDARG00000077231
GeneIDi570643
KEGGidre:570643

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7450
ZFINiZDB-GENE-070103-1 vwf

Phylogenomic databases

eggNOGiENOG410IR8A Eukaryota
ENOG41100RZ LUCA
GeneTreeiENSGT00940000155810
KOiK03900
OrthoDBi12226at2759
TreeFamiTF300299

Enzyme and pathway databases

ReactomeiR-DRE-114608 Platelet degranulation
R-DRE-140837 Intrinsic Pathway of Fibrin Clot Formation
R-DRE-216083 Integrin cell surface interactions
R-DRE-354192 Integrin alphaIIb beta3 signaling
R-DRE-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-DRE-372708 p130Cas linkage to MAPK signaling for integrins
R-DRE-430116 GP1b-IX-V activation signalling
R-DRE-5674135 MAP2K and MAPK activation
R-DRE-75892 Platelet Adhesion to exposed collagen
R-DRE-76009 Platelet Aggregation (Plug Formation)

Gene expression databases

BgeeiENSDARG00000077231 Expressed in 19 organ(s), highest expression level in heart

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR036084 Ser_inhib-like_sf
IPR002919 TIL_dom
IPR014853 Unchr_dom_Cys-rich
IPR037578 Von_Willebrand_factor
IPR002035 VWF_A
IPR001007 VWF_dom
IPR001846 VWF_type-D
IPR036465 vWFA_dom_sf
PANTHERiPTHR11339:SF361 PTHR11339:SF361, 2 hits
PfamiView protein in Pfam
PF08742 C8, 4 hits
PF01826 TIL, 3 hits
PF00092 VWA, 3 hits
PF00094 VWD, 4 hits
SMARTiView protein in SMART
SM00832 C8, 4 hits
SM00041 CT, 1 hit
SM00327 VWA, 3 hits
SM00214 VWC, 3 hits
SM00215 VWC_out, 2 hits
SM00216 VWD, 4 hits
SUPFAMiSSF53300 SSF53300, 3 hits
SSF57567 SSF57567, 5 hits
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS50234 VWFA, 3 hits
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 3 hits
PS51233 VWFD, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F9Z1_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F9Z1
Secondary accession number(s): F5XVB3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: June 20, 2018
Last modified: December 11, 2019
This is version 74 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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