We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - E7F9I2 (E7F9I2_DANRE)
Protein
Submitted name:
SRY-box transcription factor 18
Gene
sox18
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 94 – 162 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- angiogenesis Source: GO_Central
- artery development Source: ZFIN
- blood vessel development Source: ZFIN
- cell differentiation Source: GO_Central
- lymphangiogenesis Source: ZFIN
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription, DNA-templated Source: GO_Central
- vasculogenesis Source: ZFIN
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotation |
Names & Taxonomyi
Protein namesi | Submitted name: SRY-box transcription factor 18Imported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-080725-1, sox18 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-UniRule
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000058598, Expressed in vasculature of head and 41 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 94 – 162 | HMG boxInterPro annotationAdd BLAST | 69 | |
Domaini | 314 – 430 | Sox C-terminalInterPro annotationAdd BLAST | 117 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 94 | DisorderedSequence analysisAdd BLAST | 94 | |
Regioni | 267 – 289 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 31 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 49 – 87 | Polar residuesSequence analysisAdd BLAST | 39 | |
Compositional biasi | 270 – 284 | Basic residuesSequence analysisAdd BLAST | 15 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000156694 |
HOGENOMi | CLU_044994_0_0_1 |
InParanoidi | E7F9I2 |
OMAi | FFPQHMQ |
OrthoDBi | 1042753at2759 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR033392, Sox7/17/18_central IPR021934, Sox_C |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12067, Sox17_18_mid, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit PS51516, SOX_C, 1 hit |
i Sequence
Sequence statusi: Complete.
E7F9I2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNISESSCCQ EASSQPSQVA ERGTWGASSS TPGPERGHGF DRSRTTELAP
60 70 80 90 100
VPGSGTRTVS RTAAEARTGS PDSTRPGALT LGSSEGKSGG ESRIRRPMNA
110 120 130 140 150
FMVWAKDERK RLAIQNPDLH NAVLSKMLGQ SWKALSTLDK RPFVEEAERL
160 170 180 190 200
RLQHLQDHPN YKYRPRRKKQ PKKMKRVEPG LLLQGLAHGG PGDAYSPHRH
210 220 230 240 250
AHHLLPPLGH FRDLHPSGAP ELESFGLPTP EMSPLDVLEE GGGDSVFFPP
260 270 280 290 300
HMQEDVGLSS WINYHQHPNH QPGHHPHHNS HNLQHSHPHL NQKSPLACLP
310 320 330 340 350
LQEKCLVVES PNPGGLYPNM TLPESSKAGY YGQIYGSSQP QPAFTSHLGQ
360 370 380 390 400
LSPPPETSAV AQVAPPSLDA VDQLGPSAEF WGEVDRIEFD QYLSASRTRV
410 420 430
SRSAPCEESS ALISALSDAS SAVYYSACIT G
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR457456 Genomic DNA No translation available. |
RefSeqi | XP_001337702.1, XM_001337666.4 XP_017209261.1, XM_017353772.1 |
Genome annotation databases
Ensembli | ENSDART00000132992; ENSDARP00000113837; ENSDARG00000058598 |
GeneIDi | 797246 |
KEGGi | dre:797246 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR457456 Genomic DNA No translation available. |
RefSeqi | XP_001337702.1, XM_001337666.4 XP_017209261.1, XM_017353772.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000113837 |
Proteomic databases
PaxDbi | E7F9I2 |
Genome annotation databases
Ensembli | ENSDART00000132992; ENSDARP00000113837; ENSDARG00000058598 |
GeneIDi | 797246 |
KEGGi | dre:797246 |
Organism-specific databases
CTDi | 54345 |
ZFINi | ZDB-GENE-080725-1, sox18 |
Phylogenomic databases
eggNOGi | KOG0527, Eukaryota |
GeneTreei | ENSGT00940000156694 |
HOGENOMi | CLU_044994_0_0_1 |
InParanoidi | E7F9I2 |
OMAi | FFPQHMQ |
OrthoDBi | 1042753at2759 |
Gene expression databases
Bgeei | ENSDARG00000058598, Expressed in vasculature of head and 41 other tissues |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR033392, Sox7/17/18_central IPR021934, Sox_C |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12067, Sox17_18_mid, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit PS51516, SOX_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E7F9I2_DANRE | |
Accessioni | E7F9I2Primary (citable) accession number: E7F9I2 Secondary accession number(s): E9QI55 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | September 29, 2021 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |