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Entry version 62 (02 Jun 2021)
Sequence version 3 (20 Jun 2018)
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Protein
Submitted name:

Pseudopodium-enriched atypical kinase 1

Gene

peak1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pseudopodium-enriched atypical kinase 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:peak1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 25

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-100422-1, peak1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E7F7V3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000079756, Expressed in heart and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7F7V3, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1288 – 1609Protein kinaseInterPro annotationAdd BLAST322

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni23 – 65DisorderedSequence analysisAdd BLAST43
Regioni222 – 252DisorderedSequence analysisAdd BLAST31
Regioni337 – 396DisorderedSequence analysisAdd BLAST60
Regioni409 – 431DisorderedSequence analysisAdd BLAST23
Regioni478 – 528DisorderedSequence analysisAdd BLAST51
Regioni552 – 586DisorderedSequence analysisAdd BLAST35
Regioni659 – 694DisorderedSequence analysisAdd BLAST36
Regioni739 – 1016DisorderedSequence analysisAdd BLAST278
Regioni1036 – 1178DisorderedSequence analysisAdd BLAST143
Regioni1193 – 1213DisorderedSequence analysisAdd BLAST21
Regioni1382 – 1406DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi32 – 58Polar residuesSequence analysisAdd BLAST27
Compositional biasi230 – 252Acidic residuesSequence analysisAdd BLAST23
Compositional biasi337 – 362Polar residuesSequence analysisAdd BLAST26
Compositional biasi363 – 377Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi379 – 396Polar residuesSequence analysisAdd BLAST18
Compositional biasi502 – 528Polar residuesSequence analysisAdd BLAST27
Compositional biasi564 – 586Polar residuesSequence analysisAdd BLAST23
Compositional biasi739 – 781Polar residuesSequence analysisAdd BLAST43
Compositional biasi835 – 878Polar residuesSequence analysisAdd BLAST44
Compositional biasi917 – 941Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi956 – 982Polar residuesSequence analysisAdd BLAST27
Compositional biasi987 – 1003Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1084 – 1105Polar residuesSequence analysisAdd BLAST22
Compositional biasi1382 – 1405Basic and acidic residuesSequence analysisAdd BLAST24

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157591

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002882_0_0_1

TreeFam database of animal gene trees

More...
TreeFami
TF333340

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008266, Tyr_kinase_AS

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E7F7V3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSACNTFTEH VWKPGECKNC FKPKSLHRPP ESASECKTNI NAKLTNSQRS
60 70 80 90 100
TSSSRAGQVR PPVAKKPTIA VKPTMMLPCS PPGLDSEGNV PRLAEGPQVT
110 120 130 140 150
KSSPFTVWNH NSLNSLRPAG TNNNQGEDLV GQTEAYSAIS LQPTSSNNNG
160 170 180 190 200
LTDVLKEIAG LGSSPSTSRN DFFGRICSSY RRSLERGLPA ASCLHAGSSG
210 220 230 240 250
RGAMKRVSLS DSTEVISTEG GRFCYPEFSS DGDDEEEDSD EDDDGEHDSW
260 270 280 290 300
DESDEELLAM GIRMRGQPRF ANFRAATLSP VPFALVKKWN TVPLRNRSLQ
310 320 330 340 350
RFCAVDYDDS YDEILNGYPS VDSNGAPALL SYTSDHQGSG FLSTSESTTS
360 370 380 390 400
PESLASLPEE TCTESSRDTD DHRNGLPFPP NKETSSRGPS SPKSNETHKA
410 420 430 440 450
VLAIRLEEQD DSQREGGALP QALPGQPITI SFSPTEEQAK PYRVVNLEKA
460 470 480 490 500
PICKPYTVVD VSASMATKDN THLSEITPKS SVTVDPCPVS PISPQSPRSP
510 520 530 540 550
MSPVTSPSIS LSPLMPQSPI GSSSGLSGFR TKPGSIRYQE VWTSCTSPRQ
560 570 580 590 600
KIPKVDLTSG SADPRLINHK SAPTSPTAAF GSARTVPTKS PNLSEIKFNS
610 620 630 640 650
YNNAGMPPFP IIIRDEPAYA RSSKKAVKVP IVINPSAYDN LAVYKSFLGL
660 670 680 690 700
NGELPHSKPG AGERVASHTY EEIGSSESSQ PSPSEQKPPP ISADLTATGE
710 720 730 740 750
LRTTTVNDGK YRTTTGVAFH AGIQSTNPAF LAHSSLDRIR NPSSEQPPEG
760 770 780 790 800
SKDCQLASSG SSGQREKASA VLSQIVSSIQ PPVSPPESPA GQSKTCSAEE
810 820 830 840 850
LYSLPPDASR DTTVNRPKSL HCSAEPHKET PHKLLPKSQS ASAAVPPTSP
860 870 880 890 900
KSETSAPFPP VRSSSSPYHS SNLLQRHFNW TRPAGAKSTD GETSPGAEGR
910 920 930 940 950
RSSDGNKPKR WISFKSFFRR RKDEDEQKEK MEREKEKGKL LGLDGTVITV
960 970 980 990 1000
LPPPPLQRQQ WFSESKTDDP LQKPTIIFTY KSESATGGEE AELRVEEHKE
1010 1020 1030 1040 1050
SVTAEGGASS LSTPPKSRAS LLISKVMNQL PVQETEISSA TSLPAKLELS
1060 1070 1080 1090 1100
PLREPPASCP PPASPTSNSS RQADPEEEGI AHTISRSPES NSCRATYTNL
1110 1120 1130 1140 1150
GQSRANMIPV KHPRHPKASD DTLTSDPEVS ELTNKSTPPP LPKKLVPRAQ
1160 1170 1180 1190 1200
IDSSAAGKEL APRPKGEARP GGTSLSVANP LYDLESTWDT ASQSSSLSSE
1210 1220 1230 1240 1250
ARHHDESGDS LECPVGGRSL SCLTSSTSMQ GCDRRGYRST ESLTARQKQM
1260 1270 1280 1290 1300
PYRGMESWEE VVGRIRGLHT DTLRKLATRC EDRFMAGQKD HLRFGTDSWS
1310 1320 1330 1340 1350
HFRLTAGKPC CEAGDAVYYT ASFAKEPLMN YAVKICRGVV KETQQQFFHS
1360 1370 1380 1390 1400
LAVRQSIAVH FNIQQDCGHF LADVPARLLP WEQKEDKDER GGTEGGEDEK
1410 1420 1430 1440 1450
EDAAGPGGKL CSCVVVITRE VPFQTVADFV REGVERHARN PELYERQVCL
1460 1470 1480 1490 1500
LLLQLCAGLE HMKPYHVTHC DLRLENLLLV HCQPGNPWNL ELLEPNNNAA
1510 1520 1530 1540 1550
SGSSTAAASA CPARLIISNF SQAKLKNVYR KCDEFQTGIL IYEMLHRPNP
1560 1570 1580 1590 1600
FEDSPELKER EYCSSDLPQL PLRSLYSNGL QQLATLLLNP NPSERIQMAD
1610 1620 1630 1640 1650
ARACLQCLLW GPREDLFNSL NPGAGTVQRH TVLQNWLDLK RTLMMIKFAE
1660 1670 1680 1690
RSLESGCGVS LEDWLCCQYL AFSTTESLSR VIKILQQPQG VLI
Length:1,693
Mass (Da):184,346
Last modified:June 20, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6721B9862E8C78F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X1WGC5X1WGC5_DANRE
Pseudopodium-enriched atypical kina...
peak1
1,725Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX005076 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000111151; ENSDARP00000103570; ENSDARG00000079756

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005076 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiE7F7V3

Genome annotation databases

EnsembliENSDART00000111151; ENSDARP00000103570; ENSDARG00000079756

Organism-specific databases

ZFINiZDB-GENE-100422-1, peak1

Phylogenomic databases

GeneTreeiENSGT00940000157591
HOGENOMiCLU_002882_0_0_1
TreeFamiTF333340

Miscellaneous databases

Protein Ontology

More...
PROi
PR:E7F7V3

Gene expression databases

BgeeiENSDARG00000079756, Expressed in heart and 24 other tissues
ExpressionAtlasiE7F7V3, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR008266, Tyr_kinase_AS
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F7V3_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F7V3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: June 20, 2018
Last modified: June 2, 2021
This is version 62 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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