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UniProtKB - E7F7V2 (E7F7V2_DANRE)

Entry version 85 (02 Dec 2020)
Sequence version 1 (08 Mar 2011)
Previous versions | rss
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Protein
Submitted name:

Si:ch211-234p18.3

Gene

si:ch211-234p18.3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotationARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-5673001, RAF/MAP kinase cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Si:ch211-234p18.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:si:ch211-234p18.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-090311-28, si:ch211-234p18.3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E7F7V2

PRoteomics IDEntifications database

More...PRIDEi		E7F7V2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000073824, Expressed in brain and 8 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000103571

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 129PHInterPro annotationAdd BLAST108
Domaini240 – 426DHInterPro annotationAdd BLAST187
Domaini467 – 586PHInterPro annotationAdd BLAST120
Domaini633 – 748N-terminal Ras-GEFInterPro annotationAdd BLAST116
Domaini1021 – 1253Ras-GEFInterPro annotationAdd BLAST233

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni710 – 737DisorderedSequence analysisAdd BLAST28
Regioni817 – 853DisorderedSequence analysisAdd BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili150 – 191Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi834 – 853PolarSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3417, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157599

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003405_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E7F7V2

Identification of Orthologs from Complete Genome Data

More...OMAi		HHYFTVN

Database of Orthologous Groups

More...OrthoDBi		70788at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		E7F7V2

TreeFam database of animal gene trees

More...TreeFami		TF317296

Family and domain databases

Conserved Domains Database

More...CDDi		cd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.840.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR000048, IQ_motif_EF-hand-BS
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
IPR030745, RasGRF1

The PANTHER Classification System

More...PANTHERi		PTHR23113, PTHR23113, 1 hit
PTHR23113:SF193, PTHR23113:SF193, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00169, PH, 2 hits
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 2 hits
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 2 hits
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48065, SSF48065, 1 hit
SSF48366, SSF48366, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50096, IQ, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7F7V2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKGIRLNDG HVTYLGLLAK KDGTRRGCLS KKSSDNTKWH TKWFALLQNM 
        60         70         80         90        100
LFYFESESSS RPSGLYLLEG CVCDRSPSPK PSLSAKECLE KQYYFTVSFN 
       110        120        130        140        150
HENQKALELR TEDVKDCDEW VAAISHASYR NLATEHETLM QKYLHLLQIV 
       160        170        180        190        200
ETEKTVAKQL RQQIEDGEIE IERLKSEIAA MLKDNEKIQS SPTTAPSDDD 
       210        220        230        240        250
SEIKKIKKVQ SFLRGWMCRR KWKTIIQDYI RSPHAESMRK RNQVVFSMLE 
       260        270        280        290        300
AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH 
       310        320        330        340        350
QIFYQGLKAR IASWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC 
       360        370        380        390        400
KQNRDFDKLL KQYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP 
       410        420        430        440        450
HEHVERNSLD YAKSKLEELS RIMHDEVSET ENIRKNLAIE RMIVEGCEIL 
       460        470        480        490        500
LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG SLSLKKEGER QCFLFSKHLI 
       510        520        530        540        550
ICTRGSGGKL HLTKNGVVSL IDCTLIEEPE GTDDESKSEK SGQDMEHLDF 
       560        570        580        590        600
KIVVEPKDSQ SFTFILVASS RQEKSAWTSD ISQCIDNIRC NGLMMNAFEE 
       610        620        630        640        650
NSKVTVPQMI KSDASLYCDD VDIRFSKMMN SCKVLQIRYA SVERLLERLT 
       660        670        680        690        700
DLRFLSIDFL NTFLHSYRVF TSADVVLDKL ITIYKRPISA IPARSLELFF 
       710        720        730        740        750
ASSQNNKLLY GEPPKSPRAS RKFSSPPPLA ITKTSSPNRR RKLSLNIPII 
       760        770        780        790        800
TGGKALDLAA LSCSSNGYAS MYSTMSPFSK TTLDINKLYV SSPITSKIPD 
       810        820        830        840        850
EGEGKTDKAD EISLCKQDNS VREESDNDQI QSDEAEAEVS PTKSPTTPKN 
       860        870        880        890        900
VKCKNSSEFS LFSYNNGMVM SSCRELDNNR SALSAASAFA IATAGANEGT 
       910        920        930        940        950
PTKEKYRRMS LASTGFPTDQ RNGDKEFVIR RAATNRVLNV LRHWVSKHSQ 
       960        970        980        990       1000
DFETNTELKM KVISFLEEVM HDPELLTQER KAAANIIRTL TQEDPGDNQI 
      1010       1020       1030       1040       1050
CLEEVLQMAE GGKSESFENH SALEIAEQLT LLDHLVFKVI PYEEFFGQGW 
      1060       1070       1080       1090       1100
MKNDKNEKTP YIMKTTKHFN DISDLIATEI LRCEDVNVRV AVMEKWVAVA 
      1110       1120       1130       1140       1150
DICRCLHNYN AVLEITSSLN RSSIFRLKKT WLKVSKQTKT VIDKLQKLVS 
      1160       1170       1180       1190       1200
SEGRFKNLRE ALKNCDPPCV PYLGMYLTDL AFIEEGTPNY TEDNLVNFSK 
      1210       1220       1230       1240       1250
MRMISHIIRE IRQFQQTAYK IDYQPKAALY LLDRSAVMEE EGLYEASLRI 

EPKVPN
Length:1,256
Mass (Da):143,526
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EC375E5FBC2C8CD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR352253 Genomic DNA No translation available.
CR450750 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_002665395.1, XM_002665349.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000109257; ENSDARP00000103571; ENSDARG00000073824

Database of genes from NCBI RefSeq genomes

More...GeneIDi		568885

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:568885

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR352253 Genomic DNA No translation available.
CR450750 Genomic DNA No translation available.
RefSeqiXP_002665395.1, XM_002665349.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000103571

Proteomic databases

PaxDbiE7F7V2
PRIDEiE7F7V2

Genome annotation databases

EnsembliENSDART00000109257; ENSDARP00000103571; ENSDARG00000073824
GeneIDi568885
KEGGidre:568885

Organism-specific databases

ZFINiZDB-GENE-090311-28, si:ch211-234p18.3

Phylogenomic databases

eggNOGiKOG3417, Eukaryota
GeneTreeiENSGT00940000157599
HOGENOMiCLU_003405_0_1_1
InParanoidiE7F7V2
OMAiHHYFTVN
OrthoDBi70788at2759
PhylomeDBiE7F7V2
TreeFamiTF317296

Enzyme and pathway databases

ReactomeiR-DRE-5673001, RAF/MAP kinase cascade

Gene expression databases

BgeeiENSDARG00000073824, Expressed in brain and 8 other tissues

Family and domain databases

CDDicd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.10.840.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR000048, IQ_motif_EF-hand-BS
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
IPR030745, RasGRF1
PANTHERiPTHR23113, PTHR23113, 1 hit
PTHR23113:SF193, PTHR23113:SF193, 1 hit
PfamiView protein in Pfam
PF00169, PH, 2 hits
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233, PH, 2 hits
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 2 hits
SM00325, RhoGEF, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF48366, SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50096, IQ, 1 hit
PS50003, PH_DOMAIN, 2 hits
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F7V2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F7V2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: December 2, 2020
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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