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UniProtKB - E7F7E6 (E7F7E6_DANRE)

Entry version 74 (07 Apr 2021)
Sequence version 1 (08 Mar 2011)
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Protein
Submitted name:

Myotubularin-related protein 11

Gene

mtmr11

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myotubularin-related protein 11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mtmr11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-130530-726, mtmr11

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000069755, Expressed in brain and 23 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000092529

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini204 – 665Myotubularin phosphataseInterPro annotationAdd BLAST462

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni703 – 814DisorderedSequence analysisAdd BLAST112

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi722 – 764PolarSequence analysisAdd BLAST43
Compositional biasi771 – 800PolarSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1089, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160276

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021912_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E7F7E6

Identification of Orthologs from Complete Genome Data

More...OMAi		GWQRSQD

Database of Orthologous Groups

More...OrthoDBi		620702at2759

TreeFam database of animal gene trees

More...TreeFami		TF315197

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030580, MTMR11
IPR022587, MTMR12-like_C
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR029021, Prot-tyrosine_phosphatase-like

The PANTHER Classification System

More...PANTHERi		PTHR10807, PTHR10807, 1 hit
PTHR10807:SF51, PTHR10807:SF51, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12578, 3-PAP, 1 hit
PF06602, Myotub-related, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52799, SSF52799, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51339, PPASE_MYOTUBULARIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7F7E6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTGSKTTFK VRQMVPDMKE RMMSHSSLHA RGRDVLGLCC LPGECVLQRA 
        60         70         80         90        100
VLVRKKLSAK EGGGWLSGTL FCTHFRVAFV PQDSQKPDDN ADPVLLGDHD 
       110        120        130        140        150
VALASIEKVV AVGPSRTKLV TPTCSLKFTP EELVLYCRDL RVLCFLFDRL 
       160        170        180        190        200
TPDTQAVEIT YTIAKTYQPL KPGTILSFQN AALGSIEMKQ FLSNRRRDPS 
       210        220        230        240        250
MNWLECSLGW EQELERTGAS GWRVSSVNDR FEMSTSLPRF NVVPQRVLDT 
       260        270        280        290        300
ELKKTFAHFN EGRIPRWCWR HPRGSDLLRM ASFQNNIYHE KDDIRNLELV 
       310        320        330        340        350
LFGGQQLCVI VDLGEEMPSP ADIQLAHTRL RTLCLGDISS SVSVPDDKWL 
       360        370        380        390        400
STLESTRWLD YTRCCLRKAA EVCCLLRAGH MTVVLQEPED RDMNCVVCSL 
       410        420        430        440        450
VQVMCDPHCR TVAGFQGLVQ KEWITAGHKF LSRINYHRES DKEEAPVFLL 
       460        470        480        490        500
FLDCVWQLWA QYPARFQLTE DYLLALHDSV HLPLFSSFLA NSQRERCRRS 
       510        520        530        540        550
QHLPQSYTPV NGLRDVPMSV PEEPVDPPFP PVWDWALQYS SQRRARFTQP 
       560        570        580        590        600
ISQPTCPPPV LNGNLNTNLE RSWHNDGLPG SVFLLSRSTF SHPSNLLPWR 
       610        620        630        640        650
SSNSGSYWKS HRRAPSSESL SGLERLIRAC SLSEPSENNT ILHDPYEPLL 
       660        670        680        690        700
PLLLGPCVRV WRSCYLRGAL HAQAFSHPVS SCTQHPVDQL AWEVQQLREK 
       710        720        730        740        750
LAQASNRRPE NQIKHQEARR PESNLNQNAN NGTFLFSSSR VSQQQQQQAP 
       760        770        780        790        800
SSRGAAQSSA PPRPQRTASD PPRPAQRNSG KHTFLFGHQQ EPQSGQRYIP 
       810 
SPSAKLHKRP GNSQ
Length:814
Mass (Da):92,262
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C0B142C5184F592
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX537142 Genomic DNA No translation available.
CR848792 Genomic DNA No translation available.
CR933818 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		NP_001313370.1, NM_001326441.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000101753; ENSDARP00000092529; ENSDARG00000069755
ENSDART00000162393; ENSDARP00000139216; ENSDARG00000069755

Database of genes from NCBI RefSeq genomes

More...GeneIDi		101882209

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:101882209

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537142 Genomic DNA No translation available.
CR848792 Genomic DNA No translation available.
CR933818 Genomic DNA No translation available.
RefSeqiNP_001313370.1, NM_001326441.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000092529

Genome annotation databases

EnsembliENSDART00000101753; ENSDARP00000092529; ENSDARG00000069755
ENSDART00000162393; ENSDARP00000139216; ENSDARG00000069755
GeneIDi101882209
KEGGidre:101882209

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10903
ZFINiZDB-GENE-130530-726, mtmr11

Phylogenomic databases

eggNOGiKOG1089, Eukaryota
GeneTreeiENSGT00940000160276
HOGENOMiCLU_021912_1_0_1
InParanoidiE7F7E6
OMAiGWQRSQD
OrthoDBi620702at2759
TreeFamiTF315197

Gene expression databases

BgeeiENSDARG00000069755, Expressed in brain and 23 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR030580, MTMR11
IPR022587, MTMR12-like_C
IPR010569, Myotubularin-like_Pase_dom
IPR030564, Myotubularin_fam
IPR029021, Prot-tyrosine_phosphatase-like
PANTHERiPTHR10807, PTHR10807, 1 hit
PTHR10807:SF51, PTHR10807:SF51, 1 hit
PfamiView protein in Pfam
PF12578, 3-PAP, 1 hit
PF06602, Myotub-related, 2 hits
SUPFAMiSSF52799, SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339, PPASE_MYOTUBULARIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F7E6_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F7E6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: April 7, 2021
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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