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Protein
Submitted name:

MAP-kinase-activating death domain

Gene

madd

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MAP-kinase-activating death domainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:maddImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-8076 madd

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7F6X3

PeptideAtlas

More...
PeptideAtlasi
E7F6X3

PRoteomics IDEntifications database

More...
PRIDEi
E7F6X3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000003495 Expressed in 26 organ(s), highest expression level in retina

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7F6X3 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000047207

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 485UDENNInterPro annotationAdd BLAST482

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3570 Eukaryota
ENOG410XP23 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156718

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E7F6X3

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00AV

TreeFam database of animal gene trees

More...
TreeFami
TF318583

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR039980 MADD
IPR037516 Tripartite_DENN

The PANTHER Classification System

More...
PANTHERi
PTHR13008 PTHR13008, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02141 DENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

E7F6X3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLSTIVLSP LLNTTNEYIT STLYFLHTGE KPAHTDTAVE ATEKSDPSTL
60 70 80 90 100
TLSGEHSAPP AGDGTLLPGE PGSSGKSPRS KRSGRIAPQN RNSMLTSLCI
110 120 130 140 150
LSHYPFFSTF RECLYILKRM VDCCSQRLNQ RPGAPKSTQR DTMWRVFTGA
160 170 180 190 200
LSVEEKEKGS QVLQDLREIE SWVYRLLRSP VPVAGQRRVD VEVLPHELQP
210 220 230 240 250
ALTFALPDPS RFSIVDFPLH LPLELLGVDA CLQVLACILL EHKVVLQSRD
260 270 280 290 300
YNALSMSVMA FVSMIYPLEY MFPVIPLLPT CMASAEQLLL APTPYVIGVP
310 320 330 340 350
ASFFLYKCDF KMPDDVWLVD LDCNKVIVPS NAELLPPLPE PEASELKKHL
360 370 380 390 400
KQALASMSLN TQPILNLEKF QDGQELSLLP PGRDKASPSS TEFNPLIYGN
410 420 430 440 450
DVDSVDVATR VAMVRFFNSP NVLQGFQMHT RTLRLFPRPV VAFQSTSFLA
460 470 480 490 500
SRPRRNGFTE KLSHTQAVEY YGEWALNPTN LAFQRIHNNV YDPSLIGDKP
510 520 530 540 550
KWYAHQLQPV FYRVYDGNSH LAEALSGPLQ DETNDSDPTD DSGSDSEAYD
560 570 580 590 600
DSSSSYSSLG DFVNEMIKGD IQGDTPNVDP LTHAALGDAD EVEIHDFHEY
610 620 630 640 650
KGNSGEPEPE GPTEAADSQP LRSSSSTTAS SSPSTVIQGV NHEQKEPVEV
660 670 680 690 700
EPIANVTYPS SAPVLGPPPF TRPTPDPTLV DPANKKREYD NPYFEPQYGF
710 720 730 740 750
PTEEDAETDE QEESYTPRFN QNLNGNKPSR PLRPSSLKLP GESDGEGDSR
760 770 780 790 800
NSSPNSTISN NSSDGFGGLM SFASNLYKNH GTSFSLSSLA LPNKAREKNT
810 820 830 840 850
PFPSLKGARA PRALVDQKSS VIKHSPTVKR ESPSPQGRAN NTSENQQFLK
860 870 880 890 900
EVVQSVLEGQ GVGWLNMKKV RRLLENEQLR VFVLSKLNRA VQSEEDAQQE
910 920 930 940 950
VIRDVEINRK VYKGMLDILK CTVSSLEHSY TNAGLGGMAS VFSLLEIART
960 970 980 990 1000
HYQTKGADGV KQRVEGGDTE EKKSQISADS GLSVTSGSQK SDTDSLASSE
1010 1020 1030 1040 1050
PPALTRSTSQ DSEASTVVSN SSGETLGADS DLSSTAGDGL TGRHGQHLNL
1060 1070 1080 1090 1100
SRGTLSDSEI ETNPATSSVF GKTHKLKPGV KEPVGVNKAA PAPPVEDVSM
1110 1120 1130 1140 1150
RIYLCEGLLG KERSTLWDQM QFWEDAFLDA VMLEREGMGM DQGPQEMIDR
1160 1170 1180 1190 1200
YLSLGDHDRK RLEDDEDRLL ATLLHNMIAY MLMMKVGKND IRKKVRRLMG
1210 1220 1230 1240 1250
KSHIGLTHSQ EINEVLDRLA HLSGRELSIR PSGSRHIKKQ TFVVHAGTDT
1260 1270 1280 1290 1300
TGDIFFMEVC DDCIVLRSNI GTVYERWWYE KLINMTYCPK TKVLCLWRRN
1310 1320 1330 1340 1350
GQETQLNKFY TKKCRELYYC VKDSMERAAA RQQSIKPGPE LGGEFPVQDM
1360 1370 1380 1390 1400
KTGEGGLLQV TLEGINLKFM HSQVFIELNH IKKCNTVKGV FVLEEFVPET
1410 1420 1430 1440
KEVVIHKYKT PMAHQICYSV LCLFSYMAAV KGKESEGKPK MLSPRPLAS
Length:1,449
Mass (Da):160,614
Last modified:June 20, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i596215B9861EC18C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5NSM6A0A1D5NSM6_DANRE
MAP-kinase-activating death domain
madd
1,680Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YA84A0A286YA84_DANRE
MAP-kinase-activating death domain
madd
1,508Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5NS97A0A1D5NS97_DANRE
MAP-kinase-activating death domain
madd
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5NSF0A0A1D5NSF0_DANRE
MAP-kinase-activating death domain
madd
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR388195 Genomic DNA No translation available.
CU075709 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000047208; ENSDARP00000047207; ENSDARG00000003495

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR388195 Genomic DNA No translation available.
CU075709 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000047207

Proteomic databases

PaxDbiE7F6X3
PeptideAtlasiE7F6X3
PRIDEiE7F6X3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000047208; ENSDARP00000047207; ENSDARG00000003495

Organism-specific databases

ZFINiZDB-GENE-030131-8076 madd

Phylogenomic databases

eggNOGiKOG3570 Eukaryota
ENOG410XP23 LUCA
GeneTreeiENSGT00940000156718
InParanoidiE7F6X3
OrthoDBiEOG091G00AV
TreeFamiTF318583

Enzyme and pathway databases

ReactomeiR-DRE-8876198 RAB GEFs exchange GTP for GDP on RABs

Gene expression databases

BgeeiENSDARG00000003495 Expressed in 26 organ(s), highest expression level in retina
ExpressionAtlasiE7F6X3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR039980 MADD
IPR037516 Tripartite_DENN
PANTHERiPTHR13008 PTHR13008, 2 hits
PfamiView protein in Pfam
PF02141 DENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F6X3_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F6X3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: June 20, 2018
Last modified: December 5, 2018
This is version 55 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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