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Entry version 71 (02 Jun 2021)
Sequence version 1 (08 Mar 2011)
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Protein

DNA (cytosine-5-)-methyltransferase

Gene

dnmt3ba

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1298PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • DNA methylation Source: ZFIN
  • regulation of gene expression Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation, MethyltransferasePROSITE-ProRule annotationARBA annotation, RepressorARBA annotation, Transferase
LigandMetal-binding, S-adenosyl-L-methioninePROSITE-ProRule annotationARBA annotation, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA (cytosine-5-)-methyltransferaseARBA annotation (EC:2.1.1.37ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dnmt3baImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050314-4, dnmt3ba

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7F6H4

PeptideAtlas

More...
PeptideAtlasi
E7F6H4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000052402, Expressed in paraxial mesoderm and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7F6H4, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000108732

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E7F6H4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 117Calponin-homology (CH)InterPro annotationAdd BLAST103
Domaini904 – 959PWWPInterPro annotationAdd BLAST56
Domaini1070 – 1202PHD-typeInterPro annotationAdd BLAST133

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni737 – 768DisorderedSequence analysisAdd BLAST32
Regioni864 – 897DisorderedSequence analysisAdd BLAST34
Regioni1025 – 1045DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi746 – 760Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1025 – 1043Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Keywords - Domaini

Zinc-fingerARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3000, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166425

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E7F6H4

Database of Orthologous Groups

More...
OrthoDBi
1015783at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329039

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025766, ADD
IPR018117, C5_DNA_meth_AS
IPR001525, C5_MeTfrase
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR040552, DNMT3_ADD
IPR000313, PWWP_dom
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17980, ADD_DNMT3, 1 hit
PF00307, CH, 1 hit
PF00145, DNA_methylase, 1 hit
PF00855, PWWP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00293, PWWP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51533, ADD, 1 hit
PS00094, C5_MTASE_1, 1 hit
PS50021, CH, 1 hit
PS50812, PWWP, 1 hit
PS51679, SAM_MT_C5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E7F6H4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATNVSLEPN NPDDKCSRYE VLGWINETLQ TNFTQVEQCR SGACFCQLID
60 70 80 90 100
LLFPGTINLK KVKFESQKRS DFMQNYGLLQ AAFRDLEVTE PVPVNELLSG
110 120 130 140 150
KFRPNFTYLK WFKKFFYANV KQERVYNAFE ARDGQEIVPV DDVMKSPKAL
160 170 180 190 200
KSSYESGRAG EESDMEINGG RRSATYDPKW QRNLKWIRAS DMGDNYAYCT
210 220 230 240 250
TCDYNIILLA GFHDLKRHQL TQNHMKHETG RTNLPGRKQI EESISCSETM
260 270 280 290 300
LLFIQSHCLS SLPSRINRVS QRTARCILGL KYPNDIVSAC KLNPYCIYIY
310 320 330 340 350
GQVPLDVKTG DKTNCHVVLA GFFEEKQARY CIRFLDVFQP EDSASSVSGG
360 370 380 390 400
LFSILKKFEI PASNMVAVYI NDHELTSESV VSQIRELNPQ VIDLGGLYSI
410 420 430 440 450
PDTACSAGLQ THSVQVQELI ANIYRHFSTG STSNDNLKML FAGIDGLKVH
460 470 480 490 500
SNPLSNSEEF CVLVKRIHEM WSDLVSYFSS CDENNDNVKQ ICSQLENPKI
510 520 530 540 550
RLTLMFLDQA LGPLRAFGQH LQQSKSSVRA DLVEILREAS GLLRSYASSF
560 570 580 590 600
LRPQAVIRYL KEQDPAILDN EAFCLPAAEL SLGGVLEDFI SAREEELADF
610 620 630 640 650
LSTFYNECLA IYKTLTTSIA ASLPLSDSVL RAISQLLSPA GRLKVTGKNI
660 670 680 690 700
VDLAVRFGFC SKPEDSAKLN DEFLEYQLAE EENLSSTHSI ERYWCTVLKT
710 720 730 740 750
FPPTSVFKRL VLCLLVLPSP SLDATKIFAQ AIENGDADQL DDSSSESDTD
760 770 780 790 800
MTKELDSNDD NSLDNSELQI SPIKNGIMKK SRRSTSETVQ HSNAVKPCVV
810 820 830 840 850
RLEKITSQRE VNLKNDGAKN DGTLTSNTLK EDSIRGIHGW ECSLRQKPQA
860 870 880 890 900
RTVFQAGAGT WSKPAIQDVD RKPEAVKNDL SNSTPSPRRG KRDQAYNDGK
910 920 930 940 950
GFAVGELVWG KVKDFSLWPG LVVPWKGRIV PVSMRRVEWF GDGMFSEIHT
960 970 980 990 1000
DGLLPFGAFS KNFCSKSYEG LPTYKNAIYQ ILELAAERSG KLFPPSEKKG
1010 1020 1030 1040 1050
EEVKAMMDWA FGGFQPMGAD GFLPSADSSA SNKTESDSSV SDYQPPAKRK
1060 1070 1080 1090 1100
YVFKNRPSTQ ECNRDQMVQE VTSKGRKIED FCLSCGSSNT EIFHPLFKGS
1110 1120 1130 1140 1150
LCIKCKENFT ETLYRYDDDG YQSYCTVCCA GLEVILCGNA SCCRCFCKDC
1160 1170 1180 1190 1200
LNVLVGPGTF DKLKEVDPWS CYVCLPSKCY GVLKLRTDWS VRVQEFFANN
1210 1220 1230 1240 1250
SAFEFEPHRV YPSIPAHKRR PIRVLSLFDG IATGYLVLKD LGFKLERYIA
1260 1270 1280 1290 1300
SEICEDSIAV GMVKHEGKIE YVKDVRTITR KHLAEWGPFD LLIGGSPCND
1310 1320 1330 1340 1350
LSMVNPARKG LFEGTGRLFF EYYRMLTMMR PKEDDDRPFF WLFENVVAMS
1360 1370 1380 1390 1400
AHDKADICRF LECNPVMIDA VKVSPAHRAR YFWGNLPGMN RPVATSLTDN
1410 1420 1430 1440 1450
VDLQDCLESG RTAMFSKVRT ITTKSNSIKQ GKTGPLPVTM NGKEDYLWCT
1460 1470 1480 1490 1500
EMEKIFGFPK HYTDVNNMGR GQRQKVLGRS WSVPVIRHLF APLKDYFACE
Length:1,500
Mass (Da):168,951
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3703C9688ABC953C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B0S581B0S581_DANRE
DNA (cytosine-5-)-methyltransferase
dnmt3ba
1,433Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R9YJL5A0A2R9YJL5_DANRE
DNA (cytosine-5-)-methyltransferase
dnmt3ba
1,456Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX005340 Genomic DNA No translation available.
CR762393 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005167049.1, XM_005166992.3
XP_005167050.1, XM_005166993.3
XP_017212766.1, XM_017357277.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000125729; ENSDARP00000108732; ENSDARG00000052402

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
321084

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005340 Genomic DNA No translation available.
CR762393 Genomic DNA No translation available.
RefSeqiXP_005167049.1, XM_005166992.3
XP_005167050.1, XM_005166993.3
XP_017212766.1, XM_017357277.1

3D structure databases

SMRiE7F6H4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108732

Proteomic databases

PaxDbiE7F6H4
PeptideAtlasiE7F6H4

Genome annotation databases

EnsembliENSDART00000125729; ENSDARP00000108732; ENSDARG00000052402
GeneIDi321084

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
321084
ZFINiZDB-GENE-050314-4, dnmt3ba

Phylogenomic databases

eggNOGiKOG3000, Eukaryota
GeneTreeiENSGT00940000166425
InParanoidiE7F6H4
OrthoDBi1015783at2759
TreeFamiTF329039

Gene expression databases

BgeeiENSDARG00000052402, Expressed in paraxial mesoderm and 37 other tissues
ExpressionAtlasiE7F6H4, baseline and differential

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR025766, ADD
IPR018117, C5_DNA_meth_AS
IPR001525, C5_MeTfrase
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR040552, DNMT3_ADD
IPR000313, PWWP_dom
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF17980, ADD_DNMT3, 1 hit
PF00307, CH, 1 hit
PF00145, DNA_methylase, 1 hit
PF00855, PWWP, 1 hit
SMARTiView protein in SMART
SM00293, PWWP, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
SSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51533, ADD, 1 hit
PS00094, C5_MTASE_1, 1 hit
PS50021, CH, 1 hit
PS50812, PWWP, 1 hit
PS51679, SAM_MT_C5, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F6H4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F6H4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: June 2, 2021
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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