Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 71 (11 Dec 2019)
Sequence version 2 (05 Apr 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Natural killer cell triggering receptor

Gene

nktr

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Natural killer cell triggering receptorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nktrImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 24

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-1725 nktr

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7F5I0

PeptideAtlas

More...
PeptideAtlasi
E7F5I0

PRoteomics IDEntifications database

More...
PRIDEi
E7F5I0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000059097 Expressed in 27 organ(s), highest expression level in multi-cellular organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7F5I0 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000107238

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 175PPIase cyclophilin-typeInterPro annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni194 – 642DisorderedSequence analysisAdd BLAST449
Regioni658 – 784DisorderedSequence analysisAdd BLAST127
Regioni809 – 854DisorderedSequence analysisAdd BLAST46
Regioni869 – 1120DisorderedSequence analysisAdd BLAST252
Regioni1211 – 1396DisorderedSequence analysisAdd BLAST186

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi255 – 279PolyampholyteSequence analysisAdd BLAST25
Compositional biasi292 – 306PolyampholyteSequence analysisAdd BLAST15
Compositional biasi323 – 337BasicSequence analysisAdd BLAST15
Compositional biasi339 – 366PolyampholyteSequence analysisAdd BLAST28
Compositional biasi375 – 401PolyampholyteSequence analysisAdd BLAST27
Compositional biasi413 – 440BasicSequence analysisAdd BLAST28
Compositional biasi461 – 480BasicSequence analysisAdd BLAST20
Compositional biasi481 – 524PolyampholyteSequence analysisAdd BLAST44
Compositional biasi525 – 556BasicSequence analysisAdd BLAST32
Compositional biasi566 – 588PolyampholyteSequence analysisAdd BLAST23
Compositional biasi606 – 622PolarSequence analysisAdd BLAST17
Compositional biasi658 – 734PolarSequence analysisAdd BLAST77
Compositional biasi753 – 774PolyampholyteSequence analysisAdd BLAST22
Compositional biasi812 – 854PolyampholyteSequence analysisAdd BLAST43
Compositional biasi869 – 896PolyampholyteSequence analysisAdd BLAST28
Compositional biasi917 – 931PolyampholyteSequence analysisAdd BLAST15
Compositional biasi932 – 969BasicSequence analysisAdd BLAST38
Compositional biasi1009 – 1036PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1043 – 1070PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1071 – 1095PolarSequence analysisAdd BLAST25
Compositional biasi1211 – 1262PolyampholyteSequence analysisAdd BLAST52
Compositional biasi1263 – 1284BasicSequence analysisAdd BLAST22
Compositional biasi1285 – 1301PolarSequence analysisAdd BLAST17
Compositional biasi1302 – 1337BasicSequence analysisAdd BLAST36
Compositional biasi1338 – 1355PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1356 – 1371BasicSequence analysisAdd BLAST16
Compositional biasi1378 – 1396BasicSequence analysisAdd BLAST19

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0546 Eukaryota
COG0652 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158548

KEGG Orthology (KO)

More...
KOi
K12740

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSWSHNG

Database of Orthologous Groups

More...
OrthoDBi
1403619at2759

TreeFam database of animal gene trees

More...
TreeFami
TF318563

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00160 Pro_isomerase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00153 CSAPPISMRASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50891 SSF50891, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

E7F5I0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVKDRPQCY FDVEINREPV GRIVFQLFSD ICPKTSKNFL CLCTGEKGSG
60 70 80 90 100
KATGKKLCYK GSTFHRVVKN FMIQGGDFTE GNGRGGESIF GGFFEDENFT
110 120 130 140 150
LKHDRAFLLS MANRGKDTNG SQFFITTKTA PHLDGVHVVF GLVISGFEVI
160 170 180 190 200
KNIEGLKTDS ASRPYADVRV IDCGQLITKS ANDVLQGKLR KAFYSEDDSQ
210 220 230 240 250
SSSESLSEHS SLEEEPTSRK RKKSSKSKHA KRSRREAKKD RETVKTAGPA
260 270 280 290 300
SHAEGEMAEE NDGEAEQNVK REKPVVRPEE IPPVPENRFL LRRDMPTQEE
310 320 330 340 350
AIKIDVQDTD IVPNDTKPAV TKSGRKIKGR GTMRYHTPPR SKSRSESECE
360 370 380 390 400
RGSSETPPHW KEEMQRTKAY QPPSVERWSK EERWDDRSDT PRSRSESREH
410 420 430 440 450
SLGEASVYSS QHRSKKEKKK AKQKKKSKKR KHAKKHKKTK TKETSLTDGE
460 470 480 490 500
VSVSSGKRTK HSSRAERRRS RSYSRSSSRH SHRSYKSESE RRHYLSSSSR
510 520 530 540 550
DSRSYSRSRS RSYSRSDSRS ERRARSSKRS SRSRSGRSVT HSRSRSRSRY
560 570 580 590 600
RTRSRTRSNS RYSSETPTRS KKRNELRSPR KSKPTEGGIS RLDKSVPKSI
610 620 630 640 650
KGEEAKVQPS ASSESVSALP MSDSPPPSRW KPGLKPWKPS YVRIPDTDVK
660 670 680 690 700
SALASNALTS SSSNAPLETM SSLKQDIAVS QRDPSSGNSN IPDRLLERSL
710 720 730 740 750
SRSRSCSQSG SCSKSPTHYG NRSSSCSRSE SYSSYKERST VKKRKHFSSH
760 770 780 790 800
RNAQKRDNHA NRHDGGHKDT SPSSEDVSDN PYSPLHVQSD ILVQKNTLDS
810 820 830 840 850
LSALRALALK SKNLNRRKEP LMDKKSASGW ESDEENASKT NTAKVHNQHL
860 870 880 890 900
VKDEELNEMK KRQILSRCWE SESDTEIPDK TAVGEAKYLS EKEEGEASTE
910 920 930 940 950
SEYEYPLWPN LGAEMSKELK ANDEHSADTK PSKHKNKKAK RKHKHKRKNS
960 970 980 990 1000
SRSASRKSKA KKSKKHQKPK ETFHWQPPLE FGDEGEEDDS VTQTKQLHKA
1010 1020 1030 1040 1050
STDAINDGTK RNLKAEQIKQ KVSENTDQDQ KIVESQQDKL SIESSKVIDE
1060 1070 1080 1090 1100
NEKMPKIQKS KLHNNTKRDL AQSHPETLSN LSDTNLASNK PSDLNKVEPH
1110 1120 1130 1140 1150
SPECIPEAQQ LGPKATGFSP LKNILNNDNV LVPSQKDKVS SITTGSALPQ
1160 1170 1180 1190 1200
DSKQEETIPG DSCVSVVENK WKPLTGMTAV QTITRKPFIM KINKQQDQLV
1210 1220 1230 1240 1250
GKSQGVKIEI KSKSKVRPGS LFDEVRKTAR LNQRPRNQDS SSEEDSLPAA
1260 1270 1280 1290 1300
GEKPEAHNHS RSKSKSVSSH RSHRRSRSHS YSHPRSRSRS YTYSSRSYSR
1310 1320 1330 1340 1350
SRSRSRYSKG HSRSRSSTYR SYRSRTHSRS CSRGRYRGRY RSRSDSYDSY
1360 1370 1380 1390
SSHSRSRSRR RGHRRSKSSD RRSRSYRSYS RSSSRRRSHS RSSRYS
Length:1,396
Mass (Da):158,419
Last modified:April 5, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF17B82CEC886777F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QIV1E9QIV1_DANRE
Peptidyl-prolyl cis-trans isomerase
nktr
105Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8PZS4A0A2R8PZS4_DANRE
Peptidyl-prolyl cis-trans isomerase
nktr
89Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RQE5A0A2R8RQE5_DANRE
Peptidyl-prolyl cis-trans isomerase
nktr
110Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX571770 Genomic DNA No translation available.
CU463039 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_001338072.4, XM_001338036.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000127923; ENSDARP00000107238; ENSDARG00000059097

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
323005

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:323005

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571770 Genomic DNA No translation available.
CU463039 Genomic DNA No translation available.
RefSeqiXP_001338072.4, XM_001338036.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000107238

Proteomic databases

PaxDbiE7F5I0
PeptideAtlasiE7F5I0
PRIDEiE7F5I0

Genome annotation databases

EnsembliENSDART00000127923; ENSDARP00000107238; ENSDARG00000059097
GeneIDi323005
KEGGidre:323005

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4820
ZFINiZDB-GENE-030131-1725 nktr

Phylogenomic databases

eggNOGiKOG0546 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00940000158548
KOiK12740
OMAiRSWSHNG
OrthoDBi1403619at2759
TreeFamiTF318563

Gene expression databases

BgeeiENSDARG00000059097 Expressed in 27 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiE7F5I0 baseline

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F5I0_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F5I0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: April 5, 2011
Last modified: December 11, 2019
This is version 71 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again