UniProtKB - E7F578 (E7F578_DANRE)
Protein
Submitted name:
Synaptotagmin VIIa
Gene
syt7a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: GO_Central
- calcium ion binding Source: GO_Central
- clathrin binding Source: GO_Central
- phosphatidylserine binding Source: GO_Central
- SNARE binding Source: GO_Central
GO - Biological processi
- calcium-ion regulated exocytosis Source: GO_Central
- cellular response to calcium ion Source: GO_Central
- regulation of calcium ion-dependent exocytosis Source: GO_Central
- regulation of dopamine secretion Source: GO_Central
- vesicle-mediated transport Source: GO_Central
Names & Taxonomyi
Protein namesi | Submitted name: Synaptotagmin VIIaImported |
Gene namesi | Name:syt7aImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-090601-5, syt7a |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- exocytic vesicle Source: GO_Central
- synaptic vesicle Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5015310470 | 20 – 381 | Sequence analysisAdd BLAST | 362 |
Proteomic databases
PRIDEi | E7F578 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000063568, Expressed in retina and 19 other tissues |
ExpressionAtlasi | E7F578, baseline |
Interactioni
GO - Molecular functioni
- clathrin binding Source: GO_Central
- SNARE binding Source: GO_Central
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 129 – 217 | C2InterPro annotationAdd BLAST | 89 | |
Domaini | 258 – 349 | C2InterPro annotationAdd BLAST | 92 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 65 – 84 | DisorderedSequence analysisAdd BLAST | 20 |
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000157180 |
HOGENOMi | CLU_023008_7_2_1 |
InParanoidi | E7F578 |
OrthoDBi | 925064at2759 |
TreeFami | TF315600 |
Family and domain databases
CDDi | cd08386, C2A_Synaptotagmin-7, 1 hit cd08405, C2B_Synaptotagmin-7, 1 hit |
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR037732, C2A_Synaptotagmin-7 IPR037741, C2B_Synaptotagmin-7 IPR001565, Synaptotagmin |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
E7F578-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVINCVFFI FLCVFLIEAG QNNVRSKRSS GFGGLILWRR ERGVFVGDFS
60 70 80 90 100
DVCFSVFLSR NMGNKPANSP KGQPPDADGH SSVSDLANSL TGDMVMLSPG
110 120 130 140 150
SEDDDHEGPV SEKLGRIQFS LGYSFQDTTL TVKILKGQDL PAKDFSGTSD
160 170 180 190 200
PFVKIYLLPD RKHKLETKVK RKNLNPHWNE TFLFEGFPYE KVRERTLYLQ
210 220 230 240 250
VLDYDRFSRN DPIGEVSIPL NKVELGQLKS FWKDLKPCSD GSGSRGDLLV
260 270 280 290 300
SLCYNPTANT ITVNIIKARN LKAMDIGGTS DPYVKVWLMH KDKRVEKKKT
310 320 330 340 350
VTIKRCLNPV FNESFPFDVP AHVLRETTII ITVMDKDRLS RNDVIGKIYL
360 370 380
SWKSGPGEVK HWKDMLSRPR TNVAQWHALK A
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX1WDZ6 | X1WDZ6_DANRE | Synaptotagmin VIIa | syt7a | 607 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU855880 Genomic DNA No translation available. CU929279 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000093003; ENSDARP00000087435; ENSDARG00000063568 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU855880 Genomic DNA No translation available. CU929279 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | E7F578 |
Genome annotation databases
Ensembli | ENSDART00000093003; ENSDARP00000087435; ENSDARG00000063568 |
Organism-specific databases
ZFINi | ZDB-GENE-090601-5, syt7a |
Phylogenomic databases
GeneTreei | ENSGT00940000157180 |
HOGENOMi | CLU_023008_7_2_1 |
InParanoidi | E7F578 |
OrthoDBi | 925064at2759 |
TreeFami | TF315600 |
Gene expression databases
Bgeei | ENSDARG00000063568, Expressed in retina and 19 other tissues |
ExpressionAtlasi | E7F578, baseline |
Family and domain databases
CDDi | cd08386, C2A_Synaptotagmin-7, 1 hit cd08405, C2B_Synaptotagmin-7, 1 hit |
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR037732, C2A_Synaptotagmin-7 IPR037741, C2B_Synaptotagmin-7 IPR001565, Synaptotagmin |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7F578_DANRE | |
Accessioni | E7F578Primary (citable) accession number: E7F578 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | June 20, 2018 | |
Last modified: | February 10, 2021 | |
This is version 71 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |