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Entry version 80 (07 Oct 2020)
Sequence version 1 (08 Mar 2011)
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Protein

DNA-dependent protein kinase catalytic subunit

Gene

prkdc

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotationARBA annotation, Transferase
LigandATP-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-5693571, Nonhomologous End-Joining (NHEJ)
R-DRE-8866654, E3 ubiquitin ligases ubiquitinate target proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-dependent protein kinase catalytic subunitARBA annotation (EC:2.7.11.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:prkdcImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-9008, prkdc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7F4J7

PeptideAtlas

More...
PeptideAtlasi
E7F4J7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000075083, Expressed in paraxial mesoderm and 32 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000051678

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2884 – 3534FATInterPro annotationAdd BLAST651
Domaini3742 – 4119PI3K/PI4KInterPro annotationAdd BLAST378
Domaini4087 – 4119FATCInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2063 – 2083DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2743 – 2763Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, TPR repeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0891, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155633

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_224534_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E7F4J7

KEGG Orthology (KO)

More...
KOi
K06642

Identification of Orthologs from Complete Genome Data

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OMAi
MENTCTL

Database of Orthologous Groups

More...
OrthoDBi
26975at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E7F4J7

TreeFam database of animal gene trees

More...
TreeFami
TF324494

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05172, PIKKc_DNA-PK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR037706, DNA-PK_dom
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR012582, NUC194
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF08163, NUC194, 1 hit
PF00454, PI3_PI4_kinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343, FATC, 1 hit
SM01344, NUC194, 1 hit
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 4 hits
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7F4J7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAADTSTVGG IQGYLLKLHS SLEDTVSTNV AIVCHDIIGD LGQECMITKN
60 70 80 90 100
ENELVLQTSL LFAKEEGLLS FLRRSLSTEK LGTTGVEILR ETRVEIMNFL
110 120 130 140 150
GAFLQRMSAT VRGWEKNYAV ELKDTCIVVY TKDKSAKCRN PALDLLIKIL
160 170 180 190 200
YLTKDSSITQ NLRIGDMFNK FYGELCQKHK IPDTVLGCIY ELLGVLGEVH
210 220 230 240 250
PSEMVNNSDK LYKAYLGELK GQMTSTTKEP KLPVVAGCLK GIAALMVNFT
260 270 280 290 300
KSVEEDPAAS KEIFDYALKA ISPQTDIKRY AVIFAGLKLF AKHSSQFGSC
310 320 330 340 350
LMDHYISIFD VMSKHCGHIN AELKKSSYTA LESFLKQVAT LVAENIELHK
360 370 380 390 400
SKLKFFMQKF CAIIRTMDST NKELSIAIRG YGLFAAPCKV VCPQDVDLMY
410 420 430 440 450
TELIQRCKQM YLTESDRDDD NVYQLPSFLD SIASVLVHLD RIPEVYTPVL
460 470 480 490 500
ERLLVVQMDS FPQYSQRMQH ATCRSIVKVF VAMAVRGPVL WSFTSSVVHQ
510 520 530 540 550
GLIRVCSKPV LQSDERGVSS GVSQSEDSTL VRSGKWKVPS SKDYLELFKG
560 570 580 590 600
LLDCENLKDT GFVDGAPAAK NYNLRDLNRH LYDALVQSVM KIVEKLDLSV
610 620 630 640 650
QKVSAADEVQ SDASAGIVLS SDPTANLMPN KPKDFIAFIN LVDFCSELLP
660 670 680 690 700
SRNPEYFAQW MHPLCHELIL QSIRFPLVSG FYKLLSLSMG IAKKTQYFQD
710 720 730 740 750
VKQCPKQVGG STMENACFSL LAKFGKEVCV RMKQYKDELL AACLMFILSL
760 770 780 790 800
HPGMVALDIK AYIPALQAAL RLGLSHAPLA TAALDALESW SSFIPAAILQ
810 820 830 840 850
PHYTDILPHL DGYLKTTSSS EKDDSNMEVT FVSTGSSKGY GQVLLRLLKK
860 870 880 890 900
SKRFSLGDES PIAAVRRRVV RLLGHLGGQL NRSLVTAVSA EDMMKRFVAW
910 920 930 940 950
DCEKRLSFAV PFKDMKPVIY LDSFLPRVTE LALSSSDRQT KVAACELLHS
960 970 980 990 1000
LVIYMVGKGA QMTEDDKSAP PMYNLHRKVF PVLLRLACDV DQVTRQLFEP
1010 1020 1030 1040 1050
LVMQLIHWFT NNRKFESQDT VAVLEAILDG IVDPLDSTLR DFSGTCIQEF
1060 1070 1080 1090 1100
VKWSIKQTTP KQQEKSPANM KSLFKRIYSL ALHPSVFKRL GAALAFNSMY
1110 1120 1130 1140 1150
RQFREESSLV EQFVFEVLVV FVESLALAHF DEKSVGTVQQ CCSSLDHLKR
1160 1170 1180 1190 1200
IIKHKADSLN INSKRRIPRG FPADQSVCLS NVVLWLLTQC GRPQTECRHK
1210 1220 1230 1240 1250
SMELFFEFVP LLPGNSSPAM WLDEQLKQRG PGFLISCLEG GGLLSQPTLR
1260 1270 1280 1290 1300
EIEAPFSIRG TLQWMDLLLA ALDCYNTFTN LRCLQLQRIL GTCEKSSFLP
1310 1320 1330 1340 1350
AVHFFLTELS MQDIQAARAC FRLGNAGQSH FSPRETEQYN YSKCSIIVRM
1360 1370 1380 1390 1400
LEFSTMVLQK CPQDLWKLME KDVFNSSLFT LVVLAVCEPS SIGFNMADLE
1410 1420 1430 1440 1450
VMTHLPEVCF PLLKALASAP YRTQLESCIR MRITKQSVEE LCAIDLYETD
1460 1470 1480 1490 1500
TRNSHASMNL LLSACRQLHQ SGLLNSVLHS QDASYGCSLG SKLLTSVYKS
1510 1520 1530 1540 1550
IAPGTDRKSL PSMDVGSRKL ADRLVQLSFC LGDQSEQTVG LLLNTITLSV
1560 1570 1580 1590 1600
PLSGSLNPHF LSFSHGEYFY SLFQTSLNTE LLRSVDRSVP LLLSSANQNP
1610 1620 1630 1640 1650
SMVSVLLNGM LDHSFRERSV RKSQGSQLAE QVLKGWDLLR PWWDGPAATP
1660 1670 1680 1690 1700
ESKTSVLSLL AKVLQIDSSV CSNTSHPAFN AVFTTFTALL TDVSMPLNLK
1710 1720 1730 1740 1750
SQALIMLPFF TALPSMPLEE LRRALESLVA THFPMQSDEF PRGSLQCNNY
1760 1770 1780 1790 1800
MDCIRKFLEA LQLSQSPLLL KLMARVLCRD KKHIMEELFQ ACFQKIAHQS
1810 1820 1830 1840 1850
YLGKQVLLLS STYQSFQAKE VPSNFMLMGL IDRVLLPLAS HCSPQALSQF
1860 1870 1880 1890 1900
FISNIADIMT TLQTRFTKSV ESVFESQIMM KIGCCKLLEV LYSRLPKEEV
1910 1920 1930 1940 1950
YSKNSAINQA FCGTGCAEGN ELSKNLLKSC FEAFTENMTG EMVLLELRRQ
1960 1970 1980 1990 2000
FHCAAYNCAI ALISCSFNET KFYQGFLFTE KPDKNQFIFD NLIDSQRVYN
2010 2020 2030 2040 2050
FPIEIDVPIE RKKKYVMIRK EVSGENGDAP VYLSSQSYMA DSSLSEEMSQ
2060 2070 2080 2090 2100
FDFSTGVQSF SYNSQNPSGV SSSSRMRERK EVLSQDETVE LEMDELNQHE
2110 2120 2130 2140 2150
CMANMTALLR HMQRNNITPK VEEGVRPSDL PPWMKFLQGK LDNPSTPLNI
2160 2170 2180 2190 2200
RLFIAKLIIN TEEIFRPYAK HWLGPLMQLV VSSSNGGEGI HFMVVDIVVT
2210 2220 2230 2240 2250
VLSWASVASP KGNTRDEVLV NRLLGFLFKN CFHSKRAVFR HNLEIIRTVV
2260 2270 2280 2290 2300
ECWKDCLTIP YDLIYERFAG TDPNSKDNSV GIQLLGIVMA NNLPPYDAAC
2310 2320 2330 2340 2350
GIEHDRYFQS LANNLSFIRY KEVYSAAAEV IGLILNYMTE RENQIEGTLF
2360 2370 2380 2390 2400
NITVTKLMDL RKKEVDDKFI VCLSKVSKHF PPLVDRFINP VFYLLPKLHG
2410 2420 2430 2440 2450
MLKTHCLECV LSRADVIPEI FLHLKTKGLS QIMSHKDEGR QRVCLDIIHK
2460 2470 2480 2490 2500
ILACLKPEEL KEILGAVTAF ASHPSPVCRE RMYDILMWIQ DNYSDSESRE
2510 2520 2530 2540 2550
DSTSVEVLSV ARETLLQGLT DENYGLQLYV RNFWSHESRL PPETLERMLV
2560 2570 2580 2590 2600
VLKSLYSSRI EEQFLSLATD LLLEMTSHSP DFTRNMFEFP LSECKFQDYT
2610 2620 2630 2640 2650
IDSNWRMRST VLTPMFMETQ ATQGAEAAGS QAATVRGQIR ATQTSLEFSQ
2660 2670 2680 2690 2700
TLAPGAGRRS AYNWLTGSSV DTLADYSLSS DSLSSLLVFD KKRSERPQAA
2710 2720 2730 2740 2750
WRAVGAGFGS KRLTATSDDT DSRTAAERER RADILRLRRR FLKDKEKESI
2760 2770 2780 2790 2800
KFAKKEIHSQ RTERERRADL KIRQDAQVTL YRSYRVGDLP DIQIQFSSLI
2810 2820 2830 2840 2850
APLQALAQRD ATLAKQLFSS LFAGVLVEME RLKSNKETAD ILKELVQTLN
2860 2870 2880 2890 2900
AFLNKSTVYF PPFISCIQDM SYHHKALLGV EPSLVSATCL ASLQQPMGIL
2910 2920 2930 2940 2950
LLEESLLHGA GASEEPPLKR ARGKRELPPD TERWIHLAKL YRSLGDYDVV
2960 2970 2980 2990 3000
RGIFSGKIGT KSITFTALQA EAKSDYAEAV KLYNEALNKE DWDDGEPTIT
3010 3020 3030 3040 3050
EKDFWEIAAL EAYNHLTEWK SLEYCATVNI DDSSPIRLDR MWTETFYVET
3060 3070 3080 3090 3100
YLQYMMRSML KQLQMGETNQ DLLSFVDAAM KTEEHKIIME THYSQELSLL
3110 3120 3130 3140 3150
YILQEDYDRA KYYANNCMQV FMQNYSSIDP LLNRSRLTVL QSVQALTEIQ
3160 3170 3180 3190 3200
DFLNYITGDV SVNSLKFMIR RWTSHYPDAK LDPMNVWDDI ITSRCFFLDK
3210 3220 3230 3240 3250
ILKRLKSTPE NSMEVDGADQ GSGEELGVLV KTCKFNMKLQ MADSAWKQNN
3260 3270 3280 3290 3300
FPVASKLLKE LHRHAKIDDA RLLRWVHSFS RFTHKRIARL GPSEKINALL
3310 3320 3330 3340 3350
KTVPLLKDAE RQSEALSARM LRDQRILLGT TYDLMAGAAD RSPFALETLG
3360 3370 3380 3390 3400
EEKVQKILQL SQASSIAQVV EGLQIQALEL LRSAACKAEE EEQSFSQQHV
3410 3420 3430 3440 3450
NTHGIVEAYM TMANFCDRRL RESEQKEEAI SSKLQSLPEH VVKMMLKALK
3460 3470 3480 3490 3500
LSSEEARLKF PRLLQLVEVY PAETLDLMVR EVVSVPCWLL IGWISQMMAL
3510 3520 3530 3540 3550
LDKPQATAVQ HVIEEIAECY PQALIYPYMI SSENYTFEES ASGQRNREFV
3560 3570 3580 3590 3600
EKLESLLDKG GVIQGFVDAL QQLSNPEMLF KDWWDEVKNQ LDKPNLDKKK
3610 3620 3630 3640 3650
MKLQYMTELL GDAKSPRFGS YRRKFIQKFS KEVEKLLGAG GSKLYERRKD
3660 3670 3680 3690 3700
KDFLQQVDRM VQSMRGFQKE PGNMKEYSPW LSSFKAETLK NELEVPGQYD
3710 3720 3730 3740 3750
GKSKPLPEYH AKITGFDERV KVMTSIRRPK RIIIRGDDER DYPFLVKGGE
3760 3770 3780 3790 3800
DLRQDQRIEQ LFGVMNMILS QDTACSQRSL ALRTYQVIPI TSRIGLIEWM
3810 3820 3830 3840 3850
ENTCTLKDFL SSRRTEQEQK TITRPNEFYD EWISKVAGKV EGIRRYAELY
3860 3870 3880 3890 3900
KKAKRVDTVN NFRRIEQMVP DDLLKRAFVR MSTTPEAFLS LRSHFSSSHA
3910 3920 3930 3940 3950
VLCISHWILG IGDRHLSNFM INTETGGMIG IDFGHAFGSA TQFLPVPELM
3960 3970 3980 3990 4000
PFRLTRQFIN LMRPLAESGL IQSVMVHSLR AFRAEPDLLL NTMDVFVKEP
4010 4020 4030 4040 4050
SLDWKNFELK QLKKGGTWTE SVNTKEINWF PLQKVNFARR KLEGTNPSVI
4060 4070 4080 4090 4100
TSEELCLGFE KMPEYKGLLA VARGEEQHNI RARLADKDLT VEDQVDCLLD
4110
QATDPNILGR VWIGWEPWI
Length:4,119
Mass (Da):467,016
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15A8B0572C4C25EE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX322787 Genomic DNA No translation available.
CT574559 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_009301676.1, XM_009303401.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000051679; ENSDARP00000051678; ENSDARG00000075083

Database of genes from NCBI RefSeq genomes

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GeneIDi
562283

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:562283

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX322787 Genomic DNA No translation available.
CT574559 Genomic DNA No translation available.
RefSeqiXP_009301676.1, XM_009303401.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000051678

Proteomic databases

PaxDbiE7F4J7
PeptideAtlasiE7F4J7

Genome annotation databases

EnsembliENSDART00000051679; ENSDARP00000051678; ENSDARG00000075083
GeneIDi562283
KEGGidre:562283

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5591
ZFINiZDB-GENE-030131-9008, prkdc

Phylogenomic databases

eggNOGiKOG0891, Eukaryota
GeneTreeiENSGT00940000155633
HOGENOMiCLU_224534_0_0_1
InParanoidiE7F4J7
KOiK06642
OMAiMENTCTL
OrthoDBi26975at2759
PhylomeDBiE7F4J7
TreeFamiTF324494

Enzyme and pathway databases

ReactomeiR-DRE-5693571, Nonhomologous End-Joining (NHEJ)
R-DRE-8866654, E3 ubiquitin ligases ubiquitinate target proteins

Gene expression databases

BgeeiENSDARG00000075083, Expressed in paraxial mesoderm and 32 other tissues

Family and domain databases

CDDicd05172, PIKKc_DNA-PK, 1 hit
Gene3Di1.10.1070.11, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR037706, DNA-PK_dom
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR012582, NUC194
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
PfamiView protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF08163, NUC194, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
SMARTiView protein in SMART
SM01343, FATC, 1 hit
SM01344, NUC194, 1 hit
SM00146, PI3Kc, 1 hit
SUPFAMiSSF48371, SSF48371, 4 hits
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F4J7_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F4J7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: October 7, 2020
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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