UniProtKB - E7F4G8 (E7F4G8_DANRE)
Protein
Submitted name:
Inositol 1,4,5-trisphosphate receptor, type 1a
Gene
itpr1a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- inositol 1,4,5 trisphosphate binding Source: InterPro
- inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Calcium channelARBA annotation, Ion channel, Ligand-gated ion channelARBA annotation, ReceptorARBA annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Submitted name: Inositol 1,4,5-trisphosphate receptor, type 1aImported |
Gene namesi | Name:itpr1aImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-070604-3, itpr1a |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2254 – 2276 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 2288 – 2305 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 2335 – 2352 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 2372 – 2399 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 2420 – 2442 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 2551 – 2574 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSDARG00000014655, Expressed in granulocyte and 24 other tissues |
ExpressionAtlasi | E7F4G8, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 112 – 166 | MIRInterPro annotationAdd BLAST | 55 | |
Domaini | 173 – 223 | MIRInterPro annotationAdd BLAST | 51 | |
Domaini | 231 – 287 | MIRInterPro annotationAdd BLAST | 57 | |
Domaini | 294 – 358 | MIRInterPro annotationAdd BLAST | 65 | |
Domaini | 364 – 420 | MIRInterPro annotationAdd BLAST | 57 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1860 – 1887 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1908 – 1936 | DisorderedSequence analysisAdd BLAST | 29 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1573 – 1593 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 2102 – 2122 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 2675 – 2709 | Sequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1861 – 1887 | PolyampholyteSequence analysisAdd BLAST | 27 | |
Compositional biasi | 1908 – 1933 | PolyampholyteSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the InsP3 receptor family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155071 |
InParanoidi | E7F4G8 |
OMAi | FCHYLPK |
TreeFami | TF312815 |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF01365, RYDR_ITPR, 2 hits |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 4 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50919, MIR, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
E7F4G8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVDKLSSFLH IGDVCSLYAE GSTSGFISTL GLVDDRCVVQ PDAGDLNNPP
60 70 80 90 100
KKFRDCLFRL CPMNRYSAQK QFWKAAKPGG TSTTDTVLLN KLHHAADLEK
110 120 130 140 150
KQNDSENKKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT
160 170 180 190 200
LDAAGNEGSW FYIQPFYKLR SIGDNVVIGD KVVLNPVNAG QPLHASSHQL
210 220 230 240 250
VDNPGCNEVN SVNCTTSWKI VLFMKWSDNQ EIVLKGGDVV RLFHAEQEKF
260 270 280 290 300
LTCDEHRKKQ YVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
310 320 330 340 350
SLFRFKHLAT GHYLAAEMDS EHEVIRARAR NPQDKVMYTL VSVPDGNDIS
360 370 380 390 400
SIFELDPTTL RGGDSLVPRN SYVRLRHLCT NTWVHSTNQP IDKEEEKPVM
410 420 430 440 450
LRIGTSPLKE DKEAFAIVPV SPAEVRDLDF ANDASKVLAS IAAKLEKGTI
460 470 480 490 500
TQNERRSVTK LLEDLVYFVV DIPSSAQDVL EITVNKPNRE RQKLMREQNI
510 520 530 540 550
LKQIFKLLQA PFTDSGDGPM LRLEELADQR HAPFRHICRL CYRVLRYSQQ
560 570 580 590 600
DYRKNQEYIA KQFRFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI
610 620 630 640 650
DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICNA VLDPANADIL
660 670 680 690 700
IETKLVLSRF EVAGTVLGEG AEEEEEDEEE VWLFWKDSGG EVKSKSIREL
710 720 730 740 750
AQDAKDGHTE DQEVINYYRY QLNLFARMCL DRQYLAINKI SAQLDVDLIL
760 770 780 790 800
RCMSDEDLPF DLRASFCRMM LHMHVDRDPQ EQVTPVKYAR LWSEIPSQIS
810 820 830 840 850
IDDYDNDGTS SDEVKERFSQ TMEFVENYLR DVVCQSFPFS DKEKNKLTFE
860 870 880 890 900
VVNLARNLIY FGFYNFSDLL RLTKILLAIL DCVHISTPFH IKLDREPGKG
910 920 930 940 950
SNVMRSIHGV GELMTQVVLR GGGFLPASSH NPPDRDEVKA QSEPQKQDIL
960 970 980 990 1000
VMDTKLKIIE ILQFILNVRL DYRISCLLCI FKTEFDESNS QSEPSLSPES
1010 1020 1030 1040 1050
PASVQGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH
1060 1070 1080 1090 1100
DYPPLVSRAL HLLFRHFSQR QEVLQAFKQV QLLVTSQDVE NYKQIKSDLD
1110 1120 1130 1140 1150
QLRSIVEKSE LWVYKRQGSD SGLDAGEVTP EAHHKVRIRS NKPKVESTSS
1160 1170 1180 1190 1200
SNYRVVKEIL LRLSKLCVLE GISGKKNKKQ QQRLLRNMGA HSVVLELLQI
1210 1220 1230 1240 1250
PYEKGEDVQM QEIMTLAHQF LQNFCAGNQQ NQALLHKHIN LFLNPGILEA
1260 1270 1280 1290 1300
VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRSVHYLK FLQTIVKAEN
1310 1320 1330 1340 1350
KFIKKCQDIV MAELVTAGED VLVFYNDRAS FQSLVQMMRL ERERLDESSA
1360 1370 1380 1390 1400
LRYHIHLVEL LAVCTEGKNV YTEIKCNSLL PLDDIVRVVT HEDCIPEVKM
1410 1420 1430 1440 1450
AYVNFLNHCY VDTEVEMKEI YTSNHMWKLF DDFLVDVCRV CNNTSDRKHA
1460 1470 1480 1490 1500
DTVLERYVTE TIMSIVTTFF SSPFSDQSTS LQTRQPVFVQ LLQGVFRVYH
1510 1520 1530 1540 1550
CNWLLPGQKG NVEACIKVLS DVGKSRAIAI PVDLDCQVNN LFMKSNNIVQ
1560 1570 1580 1590 1600
KTALSWRLSV RNATRRDSVL TTSRDYRNII ERLQDIVSAL EERLRPLVQA
1610 1620 1630 1640 1650
ELSVLVDVLH RPELLFPEHT EAHRKCESGG FICKLIKHTK QLLEENEERL
1660 1670 1680 1690 1700
CIKVLQTLRE MMTKDRGYGE KRLLHDDTNC VSVLCCPLCS LTQVVDISLP
1710 1720 1730 1740 1750
PKQQEDRQRG EALRQLLVNR YYGFRSGGRR ESLTSFGNST LTPVGPIKSQ
1760 1770 1780 1790 1800
PGKYIVTSGS IWGLSRAEMS LMEVQCHLDR EGASDLVIDL IMNTTSDRVF
1810 1820 1830 1840 1850
HESILLAIAL LEGGNTIIQH SFFKRLTEDK NSEKFFRVFY DRMKVAQVEI
1860 1870 1880 1890 1900
KATVTVNTSD LGNKRRDDNT PDKDTPQRRR GKDSGVVVTD DAREQLLEAS
1910 1920 1930 1940 1950
AATKKAFGSY RRDADPEETF GTADGDKGGG DKGTEQGEMS PVILIMQPIL
1960 1970 1980 1990 2000
RFLQLLCENH NRDLQNFLRC QNNKNNYNLV CETLQFLDCI CGSTTGGLGL
2010 2020 2030 2040 2050
LGLYINQHNV ALINQTVESL TEYCQGPCHD NQNCIATHES NGIDIIIALI
2060 2070 2080 2090 2100
LNDINPLGRK RMDLVLELKN NASKLLLAIM ESRHDSENAE RILYNMRPKE
2110 2120 2130 2140 2150
LVEVMKMAYQ QGEAEFEDEE QENGEDHAAS PRNVGHNIYI LAHQLSRHNK
2160 2170 2180 2190 2200
ELQILLKPGG EDQALEYYTK HTSQIEIVRQ DRTMEQIVFP VPNICSFLTN
2210 2220 2230 2240 2250
ESKLRVYYGT ERDEQGSKIN DFFLHADDLF NEMRWQKKLR AQPVLYWCSR
2260 2270 2280 2290 2300
NMSFWSNVSF NLAVLINLLV AFFYPLDGVS ESQLEPSLSL LLWVCLLGSL
2310 2320 2330 2340 2350
GFVLMSPRPN AVRVLVISTV LQLGFSVGLQ HMLTLLGAFN VCNKIVFMLS
2360 2370 2380 2390 2400
FVGNRGSFTR GYRVMVMDRE FLFHLLYLLI CILGLFGHVF FYSLLLFDLV
2410 2420 2430 2440 2450
NREETLLNVI KSVTRNGRSI VLTAVLGLIL VYLFSIVGYM FFKDDFILEV
2460 2470 2480 2490 2500
NRISNGTLAK AQTSDLLAVR RLFTIIINSC ILILKCHKIH CLNPTDCVCF
2510 2520 2530 2540 2550
IDDVERACDS LWMCMITVLS HGLRSGGGVG DVLRKPSKEE RLFAARVVYD
2560 2570 2580 2590 2600
LLFFFLVIII VLNLIFGVII DTFADLRSEK QRKEEILKTT CFICGLERDK
2610 2620 2630 2640 2650
FDNKTVTFEE HIKEEHNLWH YLFFIVLVRV KDSTEYTGPE SYVAQMIKEH
2660 2670 2680 2690 2700
NLDWFPRMRA MSLVSSDGEG EQNELRSLQE KLESTMRLVS NLTNQLTELK
2710 2720 2730
EQMTEQRKHK QRLGLLGNPA HLNINPQQPA
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W4B1 | F8W4B1_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,682 | Annotation score: | ||
A0A2R8QAR1 | A0A2R8QAR1_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,745 | Annotation score: | ||
A0A2R8QJM5 | A0A2R8QJM5_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,707 | Annotation score: | ||
A0A2R8RSY9 | A0A2R8RSY9_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,726 | Annotation score: | ||
A0A2R8PWX1 | A0A2R8PWX1_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,730 | Annotation score: | ||
A0A2R8Q201 | A0A2R8Q201_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,715 | Annotation score: | ||
A0A2R8QBV7 | A0A2R8QBV7_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,726 | Annotation score: | ||
A0A2R8QHB5 | A0A2R8QHB5_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,707 | Annotation score: | ||
A0A2R8RZ36 | A0A2R8RZ36_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 2,745 | Annotation score: | ||
A0A2R8QFQ7 | A0A2R8QFQ7_DANRE | Inositol 1,4,5-trisphosphate recept... | itpr1a | 708 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX957338 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000065092; ENSDARP00000065091; ENSDARG00000014655 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX957338 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | E7F4G8 |
Genome annotation databases
Ensembli | ENSDART00000065092; ENSDARP00000065091; ENSDARG00000014655 |
Organism-specific databases
ZFINi | ZDB-GENE-070604-3, itpr1a |
Phylogenomic databases
GeneTreei | ENSGT00940000155071 |
InParanoidi | E7F4G8 |
OMAi | FCHYLPK |
TreeFami | TF312815 |
Gene expression databases
Bgeei | ENSDARG00000014655, Expressed in granulocyte and 24 other tissues |
ExpressionAtlasi | E7F4G8, baseline |
Family and domain databases
InterProi | View protein in InterPro IPR014821, Ins145_P3_rcpt IPR000493, InsP3_rcpt IPR005821, Ion_trans_dom IPR036300, MIR_dom_sf IPR016093, MIR_motif IPR013662, RIH_assoc-dom IPR000699, RIH_dom IPR035910, RyR/IP3R_RIH_dom_sf |
Pfami | View protein in Pfam PF08709, Ins145_P3_rec, 1 hit PF00520, Ion_trans, 1 hit PF02815, MIR, 1 hit PF08454, RIH_assoc, 1 hit PF01365, RYDR_ITPR, 2 hits |
PRINTSi | PR00779, INSP3RECEPTR |
SMARTi | View protein in SMART SM00472, MIR, 4 hits |
SUPFAMi | SSF100909, SSF100909, 2 hits SSF82109, SSF82109, 2 hits |
PROSITEi | View protein in PROSITE PS50919, MIR, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7F4G8_DANRE | |
Accessioni | E7F4G8Primary (citable) accession number: E7F4G8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | June 20, 2018 | |
Last modified: | April 7, 2021 | |
This is version 72 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |