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UniProtKB - E7F4G8 (E7F4G8_DANRE)

Entry version 72 (07 Apr 2021)
Sequence version 3 (20 Jun 2018)
Previous versions | rss
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Protein
Submitted name:

Inositol 1,4,5-trisphosphate receptor, type 1a

Gene

itpr1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelARBA annotation, Ion channel, Ligand-gated ion channelARBA annotation, ReceptorARBA annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Inositol 1,4,5-trisphosphate receptor, type 1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:itpr1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-070604-3, itpr1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2254 – 2276HelicalSequence analysisAdd BLAST23
Transmembranei2288 – 2305HelicalSequence analysisAdd BLAST18
Transmembranei2335 – 2352HelicalSequence analysisAdd BLAST18
Transmembranei2372 – 2399HelicalSequence analysisAdd BLAST28
Transmembranei2420 – 2442HelicalSequence analysisAdd BLAST23
Transmembranei2551 – 2574HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Endoplasmic reticulumARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		E7F4G8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000014655, Expressed in granulocyte and 24 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		E7F4G8, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini112 – 166MIRInterPro annotationAdd BLAST55
Domaini173 – 223MIRInterPro annotationAdd BLAST51
Domaini231 – 287MIRInterPro annotationAdd BLAST57
Domaini294 – 358MIRInterPro annotationAdd BLAST65
Domaini364 – 420MIRInterPro annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1860 – 1887DisorderedSequence analysisAdd BLAST28
Regioni1908 – 1936DisorderedSequence analysisAdd BLAST29

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1573 – 1593Sequence analysisAdd BLAST21
Coiled coili2102 – 2122Sequence analysisAdd BLAST21
Coiled coili2675 – 2709Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1861 – 1887PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1908 – 1933PolyampholyteSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the InsP3 receptor family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155071

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E7F4G8

Identification of Orthologs from Complete Genome Data

More...OMAi		FCHYLPK

TreeFam database of animal gene trees

More...TreeFami		TF312815

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00779, INSP3RECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00472, MIR, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50919, MIR, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

E7F4G8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDKLSSFLH IGDVCSLYAE GSTSGFISTL GLVDDRCVVQ PDAGDLNNPP 
        60         70         80         90        100
KKFRDCLFRL CPMNRYSAQK QFWKAAKPGG TSTTDTVLLN KLHHAADLEK 
       110        120        130        140        150
KQNDSENKKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT 
       160        170        180        190        200
LDAAGNEGSW FYIQPFYKLR SIGDNVVIGD KVVLNPVNAG QPLHASSHQL 
       210        220        230        240        250
VDNPGCNEVN SVNCTTSWKI VLFMKWSDNQ EIVLKGGDVV RLFHAEQEKF 
       260        270        280        290        300
LTCDEHRKKQ YVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN 
       310        320        330        340        350
SLFRFKHLAT GHYLAAEMDS EHEVIRARAR NPQDKVMYTL VSVPDGNDIS 
       360        370        380        390        400
SIFELDPTTL RGGDSLVPRN SYVRLRHLCT NTWVHSTNQP IDKEEEKPVM 
       410        420        430        440        450
LRIGTSPLKE DKEAFAIVPV SPAEVRDLDF ANDASKVLAS IAAKLEKGTI 
       460        470        480        490        500
TQNERRSVTK LLEDLVYFVV DIPSSAQDVL EITVNKPNRE RQKLMREQNI 
       510        520        530        540        550
LKQIFKLLQA PFTDSGDGPM LRLEELADQR HAPFRHICRL CYRVLRYSQQ 
       560        570        580        590        600
DYRKNQEYIA KQFRFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI 
       610        620        630        640        650
DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICNA VLDPANADIL 
       660        670        680        690        700
IETKLVLSRF EVAGTVLGEG AEEEEEDEEE VWLFWKDSGG EVKSKSIREL 
       710        720        730        740        750
AQDAKDGHTE DQEVINYYRY QLNLFARMCL DRQYLAINKI SAQLDVDLIL 
       760        770        780        790        800
RCMSDEDLPF DLRASFCRMM LHMHVDRDPQ EQVTPVKYAR LWSEIPSQIS 
       810        820        830        840        850
IDDYDNDGTS SDEVKERFSQ TMEFVENYLR DVVCQSFPFS DKEKNKLTFE 
       860        870        880        890        900
VVNLARNLIY FGFYNFSDLL RLTKILLAIL DCVHISTPFH IKLDREPGKG 
       910        920        930        940        950
SNVMRSIHGV GELMTQVVLR GGGFLPASSH NPPDRDEVKA QSEPQKQDIL 
       960        970        980        990       1000
VMDTKLKIIE ILQFILNVRL DYRISCLLCI FKTEFDESNS QSEPSLSPES 
      1010       1020       1030       1040       1050
PASVQGALDF EHIEEQAEGI FGGSEENTPL DLDDHGGRTF LRVLLHLTMH 
      1060       1070       1080       1090       1100
DYPPLVSRAL HLLFRHFSQR QEVLQAFKQV QLLVTSQDVE NYKQIKSDLD 
      1110       1120       1130       1140       1150
QLRSIVEKSE LWVYKRQGSD SGLDAGEVTP EAHHKVRIRS NKPKVESTSS 
      1160       1170       1180       1190       1200
SNYRVVKEIL LRLSKLCVLE GISGKKNKKQ QQRLLRNMGA HSVVLELLQI 
      1210       1220       1230       1240       1250
PYEKGEDVQM QEIMTLAHQF LQNFCAGNQQ NQALLHKHIN LFLNPGILEA 
      1260       1270       1280       1290       1300
VTMQHIFMNN FQLCSEINER VVQHFVHCIE THGRSVHYLK FLQTIVKAEN 
      1310       1320       1330       1340       1350
KFIKKCQDIV MAELVTAGED VLVFYNDRAS FQSLVQMMRL ERERLDESSA 
      1360       1370       1380       1390       1400
LRYHIHLVEL LAVCTEGKNV YTEIKCNSLL PLDDIVRVVT HEDCIPEVKM 
      1410       1420       1430       1440       1450
AYVNFLNHCY VDTEVEMKEI YTSNHMWKLF DDFLVDVCRV CNNTSDRKHA 
      1460       1470       1480       1490       1500
DTVLERYVTE TIMSIVTTFF SSPFSDQSTS LQTRQPVFVQ LLQGVFRVYH 
      1510       1520       1530       1540       1550
CNWLLPGQKG NVEACIKVLS DVGKSRAIAI PVDLDCQVNN LFMKSNNIVQ 
      1560       1570       1580       1590       1600
KTALSWRLSV RNATRRDSVL TTSRDYRNII ERLQDIVSAL EERLRPLVQA 
      1610       1620       1630       1640       1650
ELSVLVDVLH RPELLFPEHT EAHRKCESGG FICKLIKHTK QLLEENEERL 
      1660       1670       1680       1690       1700
CIKVLQTLRE MMTKDRGYGE KRLLHDDTNC VSVLCCPLCS LTQVVDISLP 
      1710       1720       1730       1740       1750
PKQQEDRQRG EALRQLLVNR YYGFRSGGRR ESLTSFGNST LTPVGPIKSQ 
      1760       1770       1780       1790       1800
PGKYIVTSGS IWGLSRAEMS LMEVQCHLDR EGASDLVIDL IMNTTSDRVF 
      1810       1820       1830       1840       1850
HESILLAIAL LEGGNTIIQH SFFKRLTEDK NSEKFFRVFY DRMKVAQVEI 
      1860       1870       1880       1890       1900
KATVTVNTSD LGNKRRDDNT PDKDTPQRRR GKDSGVVVTD DAREQLLEAS 
      1910       1920       1930       1940       1950
AATKKAFGSY RRDADPEETF GTADGDKGGG DKGTEQGEMS PVILIMQPIL 
      1960       1970       1980       1990       2000
RFLQLLCENH NRDLQNFLRC QNNKNNYNLV CETLQFLDCI CGSTTGGLGL 
      2010       2020       2030       2040       2050
LGLYINQHNV ALINQTVESL TEYCQGPCHD NQNCIATHES NGIDIIIALI 
      2060       2070       2080       2090       2100
LNDINPLGRK RMDLVLELKN NASKLLLAIM ESRHDSENAE RILYNMRPKE 
      2110       2120       2130       2140       2150
LVEVMKMAYQ QGEAEFEDEE QENGEDHAAS PRNVGHNIYI LAHQLSRHNK 
      2160       2170       2180       2190       2200
ELQILLKPGG EDQALEYYTK HTSQIEIVRQ DRTMEQIVFP VPNICSFLTN 
      2210       2220       2230       2240       2250
ESKLRVYYGT ERDEQGSKIN DFFLHADDLF NEMRWQKKLR AQPVLYWCSR 
      2260       2270       2280       2290       2300
NMSFWSNVSF NLAVLINLLV AFFYPLDGVS ESQLEPSLSL LLWVCLLGSL 
      2310       2320       2330       2340       2350
GFVLMSPRPN AVRVLVISTV LQLGFSVGLQ HMLTLLGAFN VCNKIVFMLS 
      2360       2370       2380       2390       2400
FVGNRGSFTR GYRVMVMDRE FLFHLLYLLI CILGLFGHVF FYSLLLFDLV 
      2410       2420       2430       2440       2450
NREETLLNVI KSVTRNGRSI VLTAVLGLIL VYLFSIVGYM FFKDDFILEV 
      2460       2470       2480       2490       2500
NRISNGTLAK AQTSDLLAVR RLFTIIINSC ILILKCHKIH CLNPTDCVCF 
      2510       2520       2530       2540       2550
IDDVERACDS LWMCMITVLS HGLRSGGGVG DVLRKPSKEE RLFAARVVYD 
      2560       2570       2580       2590       2600
LLFFFLVIII VLNLIFGVII DTFADLRSEK QRKEEILKTT CFICGLERDK 
      2610       2620       2630       2640       2650
FDNKTVTFEE HIKEEHNLWH YLFFIVLVRV KDSTEYTGPE SYVAQMIKEH 
      2660       2670       2680       2690       2700
NLDWFPRMRA MSLVSSDGEG EQNELRSLQE KLESTMRLVS NLTNQLTELK 
      2710       2720       2730
EQMTEQRKHK QRLGLLGNPA HLNINPQQPA
Length:2,730
Mass (Da):311,863
Last modified:June 20, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61747C70E17D2174
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W4B1F8W4B1_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,682Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QAR1A0A2R8QAR1_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,745Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QJM5A0A2R8QJM5_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,707Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RSY9A0A2R8RSY9_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,726Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8PWX1A0A2R8PWX1_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,730Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q201A0A2R8Q201_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,715Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QBV7A0A2R8QBV7_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,726Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QHB5A0A2R8QHB5_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,707Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RZ36A0A2R8RZ36_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
2,745Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QFQ7A0A2R8QFQ7_DANRE
Inositol 1,4,5-trisphosphate recept...
itpr1a
708Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX957338 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000065092; ENSDARP00000065091; ENSDARG00000014655

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX957338 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PeptideAtlasiE7F4G8

Genome annotation databases

EnsembliENSDART00000065092; ENSDARP00000065091; ENSDARG00000014655

Organism-specific databases

ZFINiZDB-GENE-070604-3, itpr1a

Phylogenomic databases

GeneTreeiENSGT00940000155071
InParanoidiE7F4G8
OMAiFCHYLPK
TreeFamiTF312815

Gene expression databases

BgeeiENSDARG00000014655, Expressed in granulocyte and 24 other tissues
ExpressionAtlasiE7F4G8, baseline

Family and domain databases

InterProiView protein in InterPro
IPR014821, Ins145_P3_rcpt
IPR000493, InsP3_rcpt
IPR005821, Ion_trans_dom
IPR036300, MIR_dom_sf
IPR016093, MIR_motif
IPR013662, RIH_assoc-dom
IPR000699, RIH_dom
IPR035910, RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709, Ins145_P3_rec, 1 hit
PF00520, Ion_trans, 1 hit
PF02815, MIR, 1 hit
PF08454, RIH_assoc, 1 hit
PF01365, RYDR_ITPR, 2 hits
PRINTSiPR00779, INSP3RECEPTR
SMARTiView protein in SMART
SM00472, MIR, 4 hits
SUPFAMiSSF100909, SSF100909, 2 hits
SSF82109, SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919, MIR, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F4G8_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F4G8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: June 20, 2018
Last modified: April 7, 2021
This is version 72 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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