UniProtKB - E7F4D2 (E7F4D2_DANRE)
Protein
Submitted name:
Actin filament-associated protein 1
Gene
afap1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Biological processi
- regulation of cytoskeleton organization Source: InterPro
- regulation of signal transduction Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Actin filament-associated protein 1Imported |
Gene namesi | Name:afap1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-100316-6, afap1 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000055284, Expressed in swim bladder and 23 other tissues |
ExpressionAtlasi | E7F4D2, baseline |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 153 – 249 | PHInterPro annotationAdd BLAST | 97 | |
Domaini | 316 – 410 | PHInterPro annotationAdd BLAST | 95 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 43 – 92 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 116 – 135 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 248 – 287 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 505 – 542 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 569 – 594 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 750 – 776 | DisorderedSequence analysisAdd BLAST | 27 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 601 – 635 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 654 – 688 | Sequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 61 – 88 | Pro-richSequence analysisAdd BLAST | 28 | |
Compositional biasi | 248 – 281 | PolyampholyteSequence analysisAdd BLAST | 34 | |
Compositional biasi | 519 – 542 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 578 – 594 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 762 – 776 | PolyampholyteSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00950000183067 |
HOGENOMi | CLU_014418_2_0_1 |
InParanoidi | E7F4D2 |
OMAi | SSNHYKH |
OrthoDBi | 256810at2759 |
TreeFami | TF332622 |
Family and domain databases
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR030113, AFAP IPR029907, AFAP-110 IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR14338, PTHR14338, 2 hits PTHR14338:SF8, PTHR14338:SF8, 2 hits |
Pfami | View protein in Pfam PF00169, PH, 2 hits |
SMARTi | View protein in SMART SM00233, PH, 2 hits |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
E7F4D2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEELLAELRV FLELLDREYL TAGVREKKQQ ILNILHRVLA TRGKRKKKPS
60 70 80 90 100
CKTEIHTSLP APPQMPLPEI PHPWMPPDNG PPPLPSSSLP EGYYEEAVPL
110 120 130 140 150
GPGKAPEYIT SNYDSDAMSS SYESYDEEEE DGKGQKMRHQ WPSEEASMDL
160 170 180 190 200
VKDARICAFL LRKKRFGQWT KLLCVIKDNK LLCYKSSKDQ TPQMELLLSG
210 220 230 240 250
CSITHIPKDG KKKKHELKIV HQGADALVLA VQSKEQAEQW LKVSRKLSCD
260 270 280 290 300
RPSSDGEPCH ENGISDGKDP AKGKKNSKSE QKGTVGRVTG KKITKIISLG
310 320 330 340 350
KKKPSTDEQT SSAEEDVPTC GYLNVLSNNR WRERWCQLKD NQLFLHKDRA
360 370 380 390 400
DLKTHMASLP LRGCEVIPGL DSKHPFAFRL LRNGQEVAVL EASSSESMGR
410 420 430 440 450
WLGVLLAETG STTDPAALHY DYIDVETTAN VIQLAKQSFC FTSKRAVSPN
460 470 480 490 500
PYLDNPVNGY ACPTGVALHY DDVPCINGTI PDAHYSSPAS GGRRWKDESH
510 520 530 540 550
YENTDLYENM PSPKLAARYS PKSTRTSSSS GHYSTPNSTK SLSSSSFILF
560 570 580 590 600
FSSNQMKGKK GLITNGFGAK KLDKNQPKKA NGISSTLPVK RNNSNQYKYG
610 620 630 640 650
KNRVEADAKK LQAKEEELMR KKQEIRNRLT QLKKDRKDLP AISISAVMNS
660 670 680 690 700
PRSQASLTER LKKVEDECKL KEEERVSLEL ELTEVKESLK KALNGGVTLG
710 720 730 740 750
LTIEPKTGSS SPQSPVLMRR TVDNSPISSC NTSDTETCSL PVNSASLLRR
760 770
QTQQKASPVR GHVLRKAKEW EMKSGT
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketU3JAR6 | U3JAR6_DANRE | Actin filament-associated protein 1 | afap1 | 806 | Annotation score: | ||
A0A2R8Q760 | A0A2R8Q760_DANRE | Actin filament-associated protein 1 | afap1 | 672 | Annotation score: | ||
A0A2R8RPV3 | A0A2R8RPV3_DANRE | Actin filament-associated protein 1 | afap1 | 717 | Annotation score: | ||
A0A2R8Q5J8 | A0A2R8Q5J8_DANRE | Actin filament-associated protein 1 | afap1 | 289 | Annotation score: | ||
A0A2R8QP26 | A0A2R8QP26_DANRE | Actin filament-associated protein 1 | afap1 | 213 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX465854 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSDART00000130594; ENSDARP00000107378; ENSDARG00000055284 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX465854 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000130594; ENSDARP00000107378; ENSDARG00000055284 |
Organism-specific databases
ZFINi | ZDB-GENE-100316-6, afap1 |
Phylogenomic databases
GeneTreei | ENSGT00950000183067 |
HOGENOMi | CLU_014418_2_0_1 |
InParanoidi | E7F4D2 |
OMAi | SSNHYKH |
OrthoDBi | 256810at2759 |
TreeFami | TF332622 |
Gene expression databases
Bgeei | ENSDARG00000055284, Expressed in swim bladder and 23 other tissues |
ExpressionAtlasi | E7F4D2, baseline |
Family and domain databases
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR030113, AFAP IPR029907, AFAP-110 IPR011993, PH-like_dom_sf IPR001849, PH_domain |
PANTHERi | PTHR14338, PTHR14338, 2 hits PTHR14338:SF8, PTHR14338:SF8, 2 hits |
Pfami | View protein in Pfam PF00169, PH, 2 hits |
SMARTi | View protein in SMART SM00233, PH, 2 hits |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7F4D2_DANRE | |
Accessioni | E7F4D2Primary (citable) accession number: E7F4D2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | June 20, 2018 | |
Last modified: | April 7, 2021 | |
This is version 69 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |