Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 65 (05 Jun 2019)
Sequence version 1 (08 Mar 2011)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Heterogeneous nuclear ribonucleoprotein Ua

Gene

hnrnpua

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Heterogeneous nuclear ribonucleoprotein UaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hnrnpuaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-3731 hnrnpua

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7F3J2

PeptideAtlas

More...
PeptideAtlasi
E7F3J2

PRoteomics IDEntifications database

More...
PRIDEi
E7F3J2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000015206 Expressed in 27 organ(s), highest expression level in eye

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000020535

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 40SAPInterPro annotationAdd BLAST35
Domaini177 – 373B30.2/SPRYInterPro annotationAdd BLAST197

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni42 – 159DisorderedSequence analysisAdd BLAST118
Regioni593 – 629DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 69PolyampholyteSequence analysisAdd BLAST23
Compositional biasi70 – 105AcidicSequence analysisAdd BLAST36
Compositional biasi112 – 131AcidicSequence analysisAdd BLAST20
Compositional biasi132 – 159PolyampholyteSequence analysisAdd BLAST28

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2242 Eukaryota
ENOG410ZRH1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156546

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E7F3J2

Database of Orthologous Groups

More...
OrthoDBi
778148at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E7F3J2

TreeFam database of animal gene trees

More...
TreeFami
TF317301

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12884 SPRY_hnRNP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.720.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR026745 hnRNP_U
IPR027417 P-loop_NTPase
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR003877 SPRY_dom
IPR035778 SPRY_hnRNP_U

The PANTHER Classification System

More...
PANTHERi
PTHR12381:SF11 PTHR12381:SF11, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02037 SAP, 1 hit
PF00622 SPRY, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00513 SAP, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF52540 SSF52540, 1 hit
SSF68906 SSF68906, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50800 SAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7F3J2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAINVKKLK VNELKDELKK RSLSDKGLKA DLMSRLQAAL DEEALSGTNG
60 70 80 90 100
SERRYEDGGD PAGKDLEEDP VGESMEEEEE DGGNAEAEHD DIMEEEEEDA
110 120 130 140 150
GVEMDKSDED ALLKDDDGDD DEDEEMEKFD EDDVALDKGD ADKDKKDEQK
160 170 180 190 200
NKKGVKRRRD EHGRAYFEFI EERKYSRAKS PQPPLEEEDE EFDDTTVCLD
210 220 230 240 250
TYNCDLHFKV SRDRYSASSL TMESFAYLWA GGRGSYGVDK GKACFEMKVI
260 270 280 290 300
EKIPVKHISS KGIEDHDVLV GWSLANSSYL LGEEAYSYAF SMTAKKTSNA
310 320 330 340 350
VTEDYGETFD ENDVVGCFIN FDGAEVEISF SKNGEDLGKA FTVSKDELKG
360 370 380 390 400
KPLFPHVLCH NCAVEFNFGQ QESPFFAQPD GFTLLQQIPV HDRIRGPKGP
410 420 430 440 450
ENKKDCEVIV VVGLPGSGKT EWVTKHTEAN PGKYNILGTD TILEKMMIST
460 470 480 490 500
LKRQMKDVTK LLEISLRAPL FLGKFIEIAA RKKRNYILDQ TNVSASARKR
510 520 530 540 550
KMCLFAGFQR KAVVVCPTDE EYKKRTLKKA ETDGKKVPEQ AIRKTKRIYS
560 570 580 590 600
LPVEGDCFSE VLYVELQKEE VAKLLEQYKE DSKICSLEPK PIQAGVQSKR
610 620 630 640 650
RSSKGRGGKN MFNRGGEGGL AQRGGGRGGF PHRGNFMGVP IPRGGFRRPP
660 670 680 690 700
IDFLPPHAFR EVFSRGSFSR GMVMPNRGGA PRPGPGRGNM GNRGGAMHRE
710 720 730 740 750
HMGHGGGGNF NQKFRGRGGN NRGFKNGNFR MSKAQAFNES WQQGFCNRKP
760
WSHPYSPSYY
Length:760
Mass (Da):85,131
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C37882B2466F39C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU076099 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_694691.5, XM_689599.8

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000020598; ENSDARP00000020535; ENSDARG00000015206

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
566326

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU076099 Genomic DNA No translation available.
RefSeqiXP_694691.5, XM_689599.8

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000020535

Proteomic databases

PaxDbiE7F3J2
PeptideAtlasiE7F3J2
PRIDEiE7F3J2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000020598; ENSDARP00000020535; ENSDARG00000015206
GeneIDi566326

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
566326
ZFINiZDB-GENE-030131-3731 hnrnpua

Phylogenomic databases

eggNOGiKOG2242 Eukaryota
ENOG410ZRH1 LUCA
GeneTreeiENSGT00940000156546
InParanoidiE7F3J2
OrthoDBi778148at2759
PhylomeDBiE7F3J2
TreeFamiTF317301

Gene expression databases

BgeeiENSDARG00000015206 Expressed in 27 organ(s), highest expression level in eye

Family and domain databases

CDDicd12884 SPRY_hnRNP, 1 hit
Gene3Di1.10.720.30, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR026745 hnRNP_U
IPR027417 P-loop_NTPase
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR003877 SPRY_dom
IPR035778 SPRY_hnRNP_U
PANTHERiPTHR12381:SF11 PTHR12381:SF11, 2 hits
PfamiView protein in Pfam
PF02037 SAP, 1 hit
PF00622 SPRY, 1 hit
SMARTiView protein in SMART
SM00513 SAP, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF52540 SSF52540, 1 hit
SSF68906 SSF68906, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50800 SAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F3J2_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F3J2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: June 5, 2019
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again