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Entry version 79 (07 Oct 2020)
Sequence version 1 (08 Mar 2011)
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Protein

DIS3-like exonuclease 2

Gene

dis3l2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation.UniRule annotation

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi513MagnesiumUniRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei521Important for catalytic activityUniRule annotation1
Metal bindingi522MagnesiumUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonucleaseUniRule annotation, Hydrolase, Nuclease, RNA-bindingUniRule annotationARBA annotation
Biological processCell cycle, Cell division, MitosisUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DIS3-like exonuclease 2UniRule annotation (EC:3.1.13.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dis3l2UniRule annotationImported
Synonyms:si:ch211-273k1.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-070705-171, dis3l2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7F350

PeptideAtlas

More...
PeptideAtlasi
E7F350

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000033259, Expressed in blastula and 34 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7F350, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000077707

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini501 – 851RNBInterPro annotationAdd BLAST351

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 96DisorderedSequence analysisAdd BLAST96
Regioni110 – 188DisorderedSequence analysisAdd BLAST79
Regioni203 – 227DisorderedSequence analysisAdd BLAST25
Regioni347 – 366DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi31 – 64PolarSequence analysisAdd BLAST34
Compositional biasi78 – 96PolarSequence analysisAdd BLAST19
Compositional biasi126 – 146PolyampholyteSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.UniRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNR ribonuclease family. DIS3L2 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2102, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063106

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002333_5_2_1

KEGG Orthology (KO)

More...
KOi
K18758

Identification of Orthologs from Complete Genome Data

More...
OMAi
WTRMKGP

Database of Orthologous Groups

More...
OrthoDBi
1104619at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E7F350

TreeFam database of animal gene trees

More...
TreeFami
TF315191

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03045, DIS3L2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041505, Dis3_CSD2
IPR028591, DIS3L2
IPR041093, Dis3l2_C
IPR012340, NA-bd_OB-fold
IPR001900, RNase_II/R
IPR022966, RNase_II/R_CS
IPR033771, Rrp44_CSD1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17877, Dis3l2_C_term, 1 hit
PF17849, OB_Dis3, 1 hit
PF00773, RNB, 1 hit
PF17216, Rrp44_CSD1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00955, RNB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249, SSF50249, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01175, RIBONUCLEASE_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E7F350-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFSPKAKRT PKNKDGKGAQ NLPKPQKDAY SRLLNQHQNG KFRSYLQEFV
60 70 80 90 100
EQQSEENATT SVSRSDANRR KKGHSESSYF GDSVSSPQSR PMLADTFNSF
110 120 130 140 150
HADKTFHQVT CAEDPGTNPG MLEKLHKGSA PKKASAKLKK SEKDIKASTS
160 170 180 190 200
LVGSEEGDAQ QLSGSCGEEK TRKKSKKKSS KGHLEKKDKG ACGLEVDAAE
210 220 230 240 250
KSANKNVKAS QALKGSRQID KKDINAKDGR ASGKQVFEQY MSVEDVSAGL
260 270 280 290 300
KRGELIQGVL RINPKKYKEA YIPSPDGSAD IFLDGISARN RALNGDVVVV
310 320 330 340 350
KVLPLEQSQA TKTPDVIVEA HYNGDDEMVS KMEKVSLNDK ALLTTQSVEH
360 370 380 390 400
ATTSNTPASS SERTTQKNGK VVFIVEKKHS RAVSGFLKFL PNKRFAMFSP
410 420 430 440 450
VDHRVPRVNV PLADCPADFT SRPGDYENTL FICRITQWPA DSNFAEGRLA
460 470 480 490 500
KTLGQAGEIE PETEGILTEY GVDFSEFTEE VLNCLPQDLP WSIPAHELST
510 520 530 540 550
RRDLRKECIF TIDPATARDL DDALSCKQLS DGNFEVGVHI ADVSYFVKEG
560 570 580 590 600
NALDELAGQR ATSVYLVQKV IPMLPRLLCE ELCSLNPLTD RLTFSVIWKL
610 620 630 640 650
SPEGKILSEW FGRTVICSCI KLSYDHAQSM IDAPDKHFSP EELPACSPNH
660 670 680 690 700
SIIEIQEAVL NLHNIAKQLR AQRFEGGALR LDQLKLSFTL DKESSMPQGC
710 720 730 740 750
YVYQYRDSNK LVEEFMLLAN MAVGHQIYRS YPELALLRRH PPPQTKMVDD
760 770 780 790 800
MQEFFDQMGL DIDFSSSGAL HRSLNENLGD DEYTAARKEV ITHMCSRPMQ
810 820 830 840 850
MAVYFCAGAL KDEKLFRHYA LNVPLYTHFT SPIRRYADVI VHRLLGASLN
860 870 880 890 900
CGPRLSVSGE EVHQQASHCN DRKTASKRVQ ELSSELFFAV FVKECGPLDS
910 920 930 940 950
EAMVMGVLDQ SFDVLVLRYG VQKRIYCNSL EGLKEVEFRK VGKKPEMTLV
960 970 980 990
WETDDPSKDS IKQEISIFTL LNVQLKADGA PMKYSATLKR PLAPM
Length:995
Mass (Da):110,941
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48D4A88FF4807788
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Q8H5A0A2R8Q8H5_DANRE
DIS3-like exonuclease 2
dis3l2
978Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX001029 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005163305.1, XM_005163248.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000136180; ENSDARP00000114941; ENSDARG00000033259

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
566106

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:566106

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX001029 Genomic DNA No translation available.
RefSeqiXP_005163305.1, XM_005163248.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000077707

Proteomic databases

PaxDbiE7F350
PeptideAtlasiE7F350

Genome annotation databases

EnsembliENSDART00000136180; ENSDARP00000114941; ENSDARG00000033259
GeneIDi566106
KEGGidre:566106

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
129563
ZFINiZDB-GENE-070705-171, dis3l2

Phylogenomic databases

eggNOGiKOG2102, Eukaryota
GeneTreeiENSGT00530000063106
HOGENOMiCLU_002333_5_2_1
KOiK18758
OMAiWTRMKGP
OrthoDBi1104619at2759
PhylomeDBiE7F350
TreeFamiTF315191

Gene expression databases

BgeeiENSDARG00000033259, Expressed in blastula and 34 other tissues
ExpressionAtlasiE7F350, baseline

Family and domain databases

HAMAPiMF_03045, DIS3L2, 1 hit
InterProiView protein in InterPro
IPR041505, Dis3_CSD2
IPR028591, DIS3L2
IPR041093, Dis3l2_C
IPR012340, NA-bd_OB-fold
IPR001900, RNase_II/R
IPR022966, RNase_II/R_CS
IPR033771, Rrp44_CSD1
PfamiView protein in Pfam
PF17877, Dis3l2_C_term, 1 hit
PF17849, OB_Dis3, 1 hit
PF00773, RNB, 1 hit
PF17216, Rrp44_CSD1, 1 hit
SMARTiView protein in SMART
SM00955, RNB, 1 hit
SUPFAMiSSF50249, SSF50249, 2 hits
PROSITEiView protein in PROSITE
PS01175, RIBONUCLEASE_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F350_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F350
Secondary accession number(s): F1QHV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: October 7, 2020
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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