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Entry version 66 (07 Oct 2020)
Sequence version 1 (08 Mar 2011)
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Protein
Submitted name:

Si:ch211-225b10.4

Gene

ccdc186

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Si:ch211-225b10.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ccdc186Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-100318-3, ccdc186

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7F2H4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000061020, Expressed in blastula and 31 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7F2H4, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000127125

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 171DisorderedSequence analysisAdd BLAST171
Regioni763 – 803DisorderedSequence analysisAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili256 – 276Sequence analysisAdd BLAST21
Coiled coili305 – 403Sequence analysisAdd BLAST99
Coiled coili411 – 445Sequence analysisAdd BLAST35
Coiled coili450 – 494Sequence analysisAdd BLAST45
Coiled coili503 – 548Sequence analysisAdd BLAST46
Coiled coili552 – 572Sequence analysisAdd BLAST21
Coiled coili577 – 638Sequence analysisAdd BLAST62
Coiled coili822 – 856Sequence analysisAdd BLAST35
Coiled coili924 – 944Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 41PolarSequence analysisAdd BLAST41
Compositional biasi66 – 85PolyampholyteSequence analysisAdd BLAST20
Compositional biasi93 – 111PolarSequence analysisAdd BLAST19
Compositional biasi130 – 171PolarSequence analysisAdd BLAST42
Compositional biasi771 – 803PolarSequence analysisAdd BLAST33

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0992, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00720000108851

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007958_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
RCKTKIR

Database of Orthologous Groups

More...
OrthoDBi
604365at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E7F2H4

TreeFam database of animal gene trees

More...
TreeFami
TF328785

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038830, CCDC186

The PANTHER Classification System

More...
PANTHERi
PTHR18911, PTHR18911, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

E7F2H4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPLDSQSEL SPASDPSPSP EVSTGLEEST DVLSNGSDPV LQEQEEETEP
60 70 80 90 100
DSLELDASLS GSVDKETQRQ DTDMEVQEDE GAGEHAPADV NISCDSGTAS
110 120 130 140 150
IEDSRTQDNA GESLPAVLDG QLECSGIEET TDALPQSFPS VLNGTDELKT
160 170 180 190 200
ANGQTELTRT HMTPTSSSHA EELPDVVSVL QNSQTNANLN PYDTECSRKL
210 220 230 240 250
LSEIERSLSQ ESLLDELEDE LLNSQSEGVR KGSHPNGLQK DQNSMVLFEK
260 270 280 290 300
CVQYKYSQQE KAIKGLLEEN KKHQELILGI CSEKDNMRDE LKKRMETEKQ
310 320 330 340 350
HLYTIKKFES RVEELTKELK DSRDKLVHQD QAAKNAIQQM QREMAYRLEQ
360 370 380 390 400
ANKKCEEARQ EKETMVMKYV RGEKEALDLR REKEQLEKKL REATAEVDKQ
410 420 430 440 450
ARRGNTLAQE KGRLQQLYDA KENEVTRLMR ELEKVKEEIN SHVIKVKWAQ
460 470 480 490 500
NKLKSETDSH KETKDRLKET TAKLTQAKEE TEQIRKNCQD MIRTYQESEE
510 520 530 540 550
IKSNELDAKL RETKGELEKQ KQEQTDQLEM HKAKIKELED LKRTFKEGMD
560 570 580 590 600
ELTTLRTKVK CLEDERPRWE DELCKYREII NRQKAEIQNQ REKLTAITRL
610 620 630 640 650
EEQHQRDEQE IASLQEEVEN LNSQITDLQR DIEGSRTREA ELLGFTEKLS
660 670 680 690 700
SKNAQLQSES NSLQAQLDRL NSSSRELHNK LEDTERCLSD MMDRLKTEEQ
710 720 730 740 750
QRQEEVLALQ TERTSLQTET SQLKTRVEEL RDELVTQKRK QAVNIKDLTK
760 770 780 790 800
QLLQARKKLE QVENGGCDRE GSSMGSRSSS SGSLNARGSS MDDRSPENQS
810 820 830 840 850
GSSVVVVDSF PEVDKAVLVE RIVRLQKAHA RKNEKIEFME DHIKQLVEEI
860 870 880 890 900
RKKTKIIQSY VLREESGALS SEASDFNKAH LSRRGGIMAS LYTSHPADSG
910 920 930 940 950
LTLDLSLEIN RKLQAVLEDT LLKNITLKEN LQTLGSEIER LIKQQRLPDD

TAGRK
Length:955
Mass (Da):109,126
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F1FBFA70DD2AE67
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Q6K4A0A2R8Q6K4_DANRE
Si:ch211-225b10.4
ccdc186
912Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3JAD9U3JAD9_DANRE
Si:ch211-225b10.4
ccdc186
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR932360 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_009305037.1, XM_009306762.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000153364; ENSDARP00000127125; ENSDARG00000061020

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
557112

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:557112

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR932360 Genomic DNA No translation available.
RefSeqiXP_009305037.1, XM_009306762.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000127125

Proteomic databases

PaxDbiE7F2H4

Genome annotation databases

EnsembliENSDART00000153364; ENSDARP00000127125; ENSDARG00000061020
GeneIDi557112
KEGGidre:557112

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55088
ZFINiZDB-GENE-100318-3, ccdc186

Phylogenomic databases

eggNOGiKOG0992, Eukaryota
GeneTreeiENSGT00720000108851
HOGENOMiCLU_007958_0_0_1
OMAiRCKTKIR
OrthoDBi604365at2759
PhylomeDBiE7F2H4
TreeFamiTF328785

Gene expression databases

BgeeiENSDARG00000061020, Expressed in blastula and 31 other tissues
ExpressionAtlasiE7F2H4, baseline

Family and domain databases

InterProiView protein in InterPro
IPR038830, CCDC186
PANTHERiPTHR18911, PTHR18911, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F2H4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F2H4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: October 7, 2020
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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