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UniProtKB - E7F2H2 (E7F2H2_DANRE)

Entry version 65 (10 Feb 2021)
Sequence version 1 (08 Mar 2011)
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Protein
Submitted name:

Zgc:66433

Gene

zgc:66433

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zgc:66433Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:zgc:66433Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-030131-9832, zgc:66433

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E7F2H2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000071697, Expressed in retina and 50 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000096976

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini149 – 262DUF4592InterPro annotationAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 47DisorderedSequence analysisAdd BLAST47
Regioni60 – 136DisorderedSequence analysisAdd BLAST77
Regioni202 – 234DisorderedSequence analysisAdd BLAST33
Regioni317 – 366DisorderedSequence analysisAdd BLAST50
Regioni423 – 720DisorderedSequence analysisAdd BLAST298
Regioni744 – 763DisorderedSequence analysisAdd BLAST20
Regioni772 – 808DisorderedSequence analysisAdd BLAST37
Regioni820 – 864DisorderedSequence analysisAdd BLAST45
Regioni894 – 929DisorderedSequence analysisAdd BLAST36
Regioni958 – 977DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi69 – 136PolarSequence analysisAdd BLAST68
Compositional biasi220 – 234PolarSequence analysisAdd BLAST15
Compositional biasi476 – 492AcidicSequence analysisAdd BLAST17
Compositional biasi499 – 526PolyampholyteSequence analysisAdd BLAST28
Compositional biasi539 – 568AcidicSequence analysisAdd BLAST30
Compositional biasi579 – 654PolyampholyteSequence analysisAdd BLAST76
Compositional biasi655 – 685PolarSequence analysisAdd BLAST31
Compositional biasi686 – 708PolyampholyteSequence analysisAdd BLAST23
Compositional biasi791 – 805PolyampholyteSequence analysisAdd BLAST15
Compositional biasi824 – 841PolarSequence analysisAdd BLAST18
Compositional biasi894 – 909PolarSequence analysisAdd BLAST16
Compositional biasi958 – 972PolarSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QXCA, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163031

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E7F2H2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026713, CRACD-like
IPR028030, DUF4592

The PANTHER Classification System

More...PANTHERi		PTHR47743, PTHR47743, 3 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15262, DUF4592, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

E7F2H2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRRTSSQNP GIGGSPSDCD IMASGSPDVT AANEPSEATE ECSGKKKSKF 
        60         70         80         90        100
QTFKNFFVKK KRKESLSPSS ESGLKASQSS DDVNTSEPSI SHAKSDNDPG 
       110        120        130        140        150
SKINLGNKAM SHDSVFVSDS PSSENNEGLG TSQDSLHGKV KSLQLQLKQA 
       160        170        180        190        200
IRLGSPPALL CGRKAEDTGA FSEDDGLPCS PPDYSSLHTV LATPLHTSVD 
       210        220        230        240        250
LTQSSLSMEA SDSEDDQMSY DASSRPSTPQ VSVPVDFSLP ASSVSCLNSS 
       260        270        280        290        300
AARHRIAVKA NARAKRKPAS RQMLDKGRDL REKLLLRDTE DKLRMVTSIG 
       310        320        330        340        350
EHECEGELVN ISDNESFASE HEDEEMTDSG QIQKTSPKSS ISAGDDSEGE 
       360        370        380        390        400
ECDHVPESEV PQSSWEIPVT LELQAHDDAD DFLLDTGCEV VPEEQGSLLE 
       410        420        430        440        450
EVLSSLKSPL ASGLTLEHEN VSLQSEVEDA NSKSIVAQLE DEDSKDLLNP 
       460        470        480        490        500
SEPAVAMNEQ APPPDSLSES SVDSGEISEE TTEEEELLEF IGEESVEPSH 
       510        520        530        540        550
SQVPEEHEEK RVHNAESARE DEELLESPVA FIDNVKESDV TEDEAELEIQ 
       560        570        580        590        600
DGGDDGERGD DGDSGNDGDS GNDGDSGNGG DDGDDKLTEV EPEKSEDSTN 
       610        620        630        640        650
DVEPQEDKPS SPEPENHEAS DDERDLVVLK VENVHEPDHT ERDDVWRSTE 
       660        670        680        690        700
TSDEPEASKS SAVEILVSPQ QESPILRCQF SKSSMSSLEK EEDPLPIRLE 
       710        720        730        740        750
ESGEPQEASS EEAKVVVSEQ QVPELPVSIA EVRPRFTIAP AWQRSLASPE 
       760        770        780        790        800
SQTEDTNVLS PQTTQVIVPI LEERPKPART QSSPTLPVQK EAVHVEEEKN 
       810        820        830        840        850
PENPFGVRLR KTPVLHRYGL DGEASWSGTQ TAESVGPQET PDQEQNDRKP 
       860        870        880        890        900
ILLKKPELMF DPGMSARKVP ETVGRMSVGS SESPSWISVA RQKQRNFIES 
       910        920        930        940        950
SSPENSPEKL PAQVQGDVKR QDSSPSLSAP VVKEQLTQPC SPLQVFCSLE 
       960        970        980        990 
LSNTSMVEKE SKRISSPSTA PLAQDEPPWL ALAKKKAKAW SEMPQIVQ
Length:998
Mass (Da):108,433
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB42ED08C26391E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1R4Q3F1R4Q3_DANRE
Zgc:66433
zgc:66433
991Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QHW1E9QHW1_DANRE
Zgc:66433
zgc:66433
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IJU0A0A0R4IJU0_DANRE
Zgc:66433
zgc:66433
993Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8PWY4A0A2R8PWY4_DANRE
Zgc:66433
zgc:66433
978Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QIE5E9QIE5_DANRE
Zgc:66433
zgc:66433
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QBR5E9QBR5_DANRE
Zgc:66433
zgc:66433
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR774199 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000106198; ENSDARP00000096976; ENSDARG00000071697
ENSDART00000182539; ENSDARP00000155944; ENSDARG00000071697

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR774199 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096976

Proteomic databases

PaxDbiE7F2H2

Genome annotation databases

EnsembliENSDART00000106198; ENSDARP00000096976; ENSDARG00000071697
ENSDART00000182539; ENSDARP00000155944; ENSDARG00000071697

Organism-specific databases

ZFINiZDB-GENE-030131-9832, zgc:66433

Phylogenomic databases

eggNOGiENOG502QXCA, Eukaryota
GeneTreeiENSGT00940000163031
InParanoidiE7F2H2

Gene expression databases

BgeeiENSDARG00000071697, Expressed in retina and 50 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR026713, CRACD-like
IPR028030, DUF4592
PANTHERiPTHR47743, PTHR47743, 3 hits
PfamiView protein in Pfam
PF15262, DUF4592, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F2H2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F2H2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: February 10, 2021
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
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