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UniProtKB - E7F2B6 (E7F2B6_DANRE)

Entry version 65 (07 Apr 2021)
Sequence version 1 (08 Mar 2011)
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Protein

Poly(ADP-ribose) glycohydrolase

Gene

parga

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei531UniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei534SubstrateUniRule annotation1
Binding sitei548Substrate; via amide nitrogenUniRule annotation1
Active sitei549UniRule annotation1
Active sitei550UniRule annotation1
Binding sitei589SubstrateUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-110362, POLB-Dependent Long Patch Base Excision Repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Poly(ADP-ribose) glycohydrolaseARBA annotation (EC:3.2.1.143ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pargaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-070117-757, parga

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E7F2B6

PeptideAtlas

More...PeptideAtlasi		E7F2B6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000061114, Expressed in blastula and 25 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000102096

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 256DisorderedSequence analysisAdd BLAST256
Regioni756 – 777DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18PolyampholyteSequence analysisAdd BLAST18
Compositional biasi40 – 55PolyampholyteSequence analysisAdd BLAST16
Compositional biasi78 – 132PolarSequence analysisAdd BLAST55
Compositional biasi143 – 158PolarSequence analysisAdd BLAST16
Compositional biasi159 – 173PolyampholyteSequence analysisAdd BLAST15
Compositional biasi186 – 200PolyampholyteSequence analysisAdd BLAST15
Compositional biasi203 – 240PolarSequence analysisAdd BLAST38
Compositional biasi241 – 255PolyampholyteSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the poly(ADP-ribose) glycohydrolase family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2064, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003652

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013388_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E7F2B6

Identification of Orthologs from Complete Genome Data

More...OMAi		HVRLPCA

Database of Orthologous Groups

More...OrthoDBi		730627at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		E7F2B6

TreeFam database of animal gene trees

More...TreeFami		TF323527

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007724, Poly_GlycHdrlase

The PANTHER Classification System

More...PANTHERi		PTHR12837, PTHR12837, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05028, PARG_cat, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7F2B6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSCNTEPKR HEVDVTMSDD AGSDEPEINE SNQTGMTDDE KISELTRKRK 
        60         70         80         90        100
EQNDESVNQN QSSLANCEID TKGIIYRDTP ASNDSSTQTK PSNGERASES 
       110        120        130        140        150
NSPDPKVGKL TCLSTEKSET NLSLSLNAGD TTVEDVEMSP ESPVCQAPQS 
       160        170        180        190        200
SNSEEKSVCS DLPEGHLREG PTEEPKPSIP SPEPVKDTGD DIKDDSDVVP 
       210        220        230        240        250
METNDTEEPN SCAGASVSDN VPTTEPDSQT QASSLKSEQV PAEQEEPDWR 
       260        270        280        290        300
GTPIENLRRM PKCGQTLPHL RATDNHRVLI RTDLLKEGQV PVPYPTKFRD 
       310        320        330        340        350
SWDDMNVKMP CSEKNMFPME NEDGSGVQSR WELIRSALEG ECKSSLDIRD 
       360        370        380        390        400
AILSYNTAHA KRWDFTALNV LCTEGMENDE VQHLFNTILP KMVKLVLNTP 
       410        420        430        440        450
KICTQPIPLL KTKMNQSLTM SQEQIACLLA NAFFCTFPRR NSRKSEYANY 
       460        470        480        490        500
PEINFYRLFE GSSQRKIEKL KTLLCYFRRV TESMPTGLVT FKRQSLTTFP 
       510        520        530        540        550
KWESSKSPLS HLHITCKGTI EDQGYGMLQV DFANRMVGGG VTGLGLVQEE 
       560        570        580        590        600
IRFLINPELI VSRLFTEVLD HNECLIITGT EQYSKYSGYA ESFKWEDNHK 
       610        620        630        640        650
DKIPRDGWQR RCTEIVAMDA LHYRNFMDQF QPEKMTRELN KAYCGFMRPG 
       660        670        680        690        700
VNPLNLSAVA TGNWGCGAFG GDTRLKALLQ LMAAAEAGRD VAYFTFGDEA 
       710        720        730        740        750
LMRDVQDLHK FLKDNCVTVG SLYVYLKQYS SIVSKQAHRP NINLYGFLYE 
       760        770 
KVGTNTDPEP SDSTSTTATS PSPADCH
Length:777
Mass (Da):86,980
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF0BA7F885913491
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX927294 Genomic DNA No translation available.
CR456683 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_687541.4, XM_682449.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000115023; ENSDARP00000102096; ENSDARG00000061114

Database of genes from NCBI RefSeq genomes

More...GeneIDi		559134

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:559134

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX927294 Genomic DNA No translation available.
CR456683 Genomic DNA No translation available.
RefSeqiXP_687541.4, XM_682449.5

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000102096

Proteomic databases

PaxDbiE7F2B6
PeptideAtlasiE7F2B6

Genome annotation databases

EnsembliENSDART00000115023; ENSDARP00000102096; ENSDARG00000061114
GeneIDi559134
KEGGidre:559134

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		559134
ZFINiZDB-GENE-070117-757, parga

Phylogenomic databases

eggNOGiKOG2064, Eukaryota
GeneTreeiENSGT00390000003652
HOGENOMiCLU_013388_2_0_1
InParanoidiE7F2B6
OMAiHVRLPCA
OrthoDBi730627at2759
PhylomeDBiE7F2B6
TreeFamiTF323527

Enzyme and pathway databases

ReactomeiR-DRE-110362, POLB-Dependent Long Patch Base Excision Repair

Gene expression databases

BgeeiENSDARG00000061114, Expressed in blastula and 25 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR007724, Poly_GlycHdrlase
PANTHERiPTHR12837, PTHR12837, 1 hit
PfamiView protein in Pfam
PF05028, PARG_cat, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F2B6_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F2B6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: April 7, 2021
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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