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UniProtKB - E7F226 (E7F226_DANRE)
Protein
Submitted name:
Arginine-glutamic acid dipeptide (RE) repeats a
Gene
rerea
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- chromatin binding Source: InterPro
- sequence-specific DNA binding Source: InterPro
- transcription corepressor activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- cartilage development Source: ZFIN
- cartilage morphogenesis Source: ZFIN
- inner ear development Source: ZFIN
- negative regulation of smoothened signaling pathway Source: ZFIN
- pharyngeal system development Source: ZFIN
- regulation of fibroblast growth factor receptor signaling pathway Source: ZFIN
- regulation of histone deacetylation Source: ZFIN
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Arginine-glutamic acid dipeptide (RE) repeats aImported |
Gene namesi | Name:rereaImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-060718-1, rerea |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusARBA annotationPTM / Processingi
Keywords - PTMi
AcetylationARBA annotation, PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | E7F226 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000077353, Expressed in embryo and 35 other tissues |
ExpressionAtlasi | E7F226, baseline |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 102 – 240 | BAHInterPro annotationAdd BLAST | 139 | |
Domaini | 241 – 344 | ELM2InterPro annotationAdd BLAST | 104 | |
Domaini | 348 – 400 | SANTInterPro annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 87 | DisorderedSequence analysisAdd BLAST | 87 | |
Regioni | 421 – 452 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 499 – 1094 | DisorderedSequence analysisAdd BLAST | 596 | |
Regioni | 1123 – 1190 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 1505 – 1531 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 36 | Basic and acidic residuesSequence analysisAdd BLAST | 36 | |
Compositional biasi | 421 – 443 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 513 – 528 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 534 – 583 | Polar residuesSequence analysisAdd BLAST | 50 | |
Compositional biasi | 584 – 626 | Basic and acidic residuesSequence analysisAdd BLAST | 43 | |
Compositional biasi | 645 – 668 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 669 – 705 | Polar residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 734 – 752 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 771 – 805 | Pro residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 814 – 828 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 829 – 866 | Polar residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 867 – 892 | Pro residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 904 – 922 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1003 – 1027 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 1028 – 1050 | Pro residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 1067 – 1081 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1123 – 1170 | Basic and acidic residuesSequence analysisAdd BLAST | 48 |
Keywords - Domaini
Zinc-fingerARBA annotationPhylogenomic databases
eggNOGi | KOG2133, Eukaryota |
GeneTreei | ENSGT00940000153615 |
HOGENOMi | CLU_005292_1_0_1 |
InParanoidi | E7F226 |
OrthoDBi | 136778at2759 |
PhylomeDBi | E7F226 |
TreeFami | TF328554 |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR002951, Atrophin-like IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
Pfami | View protein in Pfam PF03154, Atrophin-1, 1 hit PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
E7F226-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTADKEKDKE RERDRDRDRD REKRDKTRES ESSRPRRSCT LEGGAKNYAE
60 70 80 90 100
SEHSEDDDNE TPGAATAEEA TKKSKKKLPK KKSRYERTEN GEITSFITED
110 120 130 140 150
DIVYRPGDCV YIESRRPNTP YFICSIQDFK LSKRDHLLMN VKWYYRQSEV
160 170 180 190 200
PDSVYQHLVQ DRNNENDSGR ELVITDPVVK SRELFISDYV DTYHAAALRG
210 220 230 240 250
KCNISHFSDI FAAREFKARI DSFFYILGYN PETRRLNSTQ GEIRVGPSHQ
260 270 280 290 300
AKLPELQPFP SPGGQTVTEN EELVWMPGVN DCDLLMYLRA ARSMAAFAGM
310 320 330 340 350
CDGGSTEDGC LAASRDDTTL NALNTLHESS YDAGKALQRL VKKPVPKLIE
360 370 380 390 400
KCWSEDEVKR FIKGLRQYGK NFFRIRKELL PNKETGELIT FYYYWKKTPE
410 420 430 440 450
AASCRAHRRH RRQPVFRRIK TRTASTPVNT PSRPPSSEFL DLSSASEDDF
460 470 480 490 500
DSEDSEQELK GYACRHCFTT TSKDWHHGGR ENILLCTDCR IHFKKYGELP
510 520 530 540 550
PIEKPVDPPP FMFKPVKEED DGLSGKHSMR TRRNRGSMST LRSGRKKQTA
560 570 580 590 600
SPDGRASPTN EDLRSSGRTS PSAASTSSTD SKTDSMKKPS KKTKEEAPSP
610 620 630 640 650
MKSAKRQREK GASDTEESER ASAKKSKTQE ISVPNSPSEC EGEGEGESSD
660 670 680 690 700
GRSVNDEGSS DPKDIDQDNR SSSPSIPSPR DNESDSDSSA QQQILQGQHP
710 720 730 740 750
PVIQCQTGTL PPAPPPAAAA STTPTSGAPS LSSQPSPSIP PTSMPPQQIP
760 770 780 790 800
PAGPLSLIQS GVQRLPSPHS PLQGMPQPPP PSQTCPQALQ PPLHGPMPPM
810 820 830 840 850
GHPLQAGPSH MPHPHALPTQ PFPMAQSQVP PSPLSGQAQA ASLSQQQRPH
860 870 880 890 900
TPPSQSQSSS QSGSQPPREQ PLPPAPLPMP HIKPPPTTPI PQMPNAQSHK
910 920 930 940 950
HPSHPPFPQM PSNLPPPPAL KPLSSLSNHH PPSAHPPPLQ LMSQSQQLQP
960 970 980 990 1000
PPVQPPVLTQ SQTLPATGSQ APPPAPPLPS SSSASHSAPS QPPFPPHSFM
1010 1020 1030 1040 1050
PGSSPVLSPS TVPTSVSSSM TTLQQPPPSI SMPLPASVSA PCPGPSTVPP
1060 1070 1080 1090 1100
VQIKEEPLDE TEEPESPPPP QRSPSPPPTI VNTPSHASQS ARFYKHLDRG
1110 1120 1130 1140 1150
YNTCARTDFY FTPLASSKLA KKREEALEKA KREAEQKARE EKEKEREREK
1160 1170 1180 1190 1200
EREREREREK EAERAAKASS SSHESRMGEP PMAGSAHMRT SFDPPPTTIA
1210 1220 1230 1240 1250
TVPPYIGPDT PALRTLSEYA RPHVMSPTNR NHPFFVSLNP TDPLLAYHLP
1260 1270 1280 1290 1300
GLYNADPSMR ERELREREIR EREIRERELR MERMKPGFEV KPPELDSLHP
1310 1320 1330 1340 1350
SANPMEHFAR HGPIGLPPMA GPHPFASFHP GLNPLERERL ALAGPQLRPE
1360 1370 1380 1390 1400
MTYPERLAER LHVERLANDP MARLQMFNVT PHHHQHSHIH SHLHLHQQDP
1410 1420 1430 1440 1450
LHQGGGECLV CPPGSGAHPL VDPLAGGPHL ARFPYPPGAI PNPLLGQPPH
1460 1470 1480 1490 1500
EHEMLRHPVF GTPYPRDLPA GLPPPMSAAH QLQAMHAQSA ELQRLAMEQQ
1510 1520 1530
WLHGHHHMHG GPLPGQEDYY SRLKKESDKQ L
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF1QQN6 | F1QQN6_DANRE | Arginine-glutamic acid dipeptide (R... | rerea | 1,390 | Annotation score: | ||
E9QE77 | E9QE77_DANRE | Arginine-glutamic acid dipeptide (R... | rerea | 131 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL928977 Genomic DNA No translation available. AL929188 Genomic DNA No translation available. AL954857 Genomic DNA No translation available. |
RefSeqi | XP_005162258.1, XM_005162201.3 XP_005162260.1, XM_005162203.3 |
Genome annotation databases
Ensembli | ENSDART00000111345; ENSDARP00000102789; ENSDARG00000077353 |
GeneIDi | 569081 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL928977 Genomic DNA No translation available. AL929188 Genomic DNA No translation available. AL954857 Genomic DNA No translation available. |
RefSeqi | XP_005162258.1, XM_005162201.3 XP_005162260.1, XM_005162203.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000102789 |
Proteomic databases
PeptideAtlasi | E7F226 |
Genome annotation databases
Ensembli | ENSDART00000111345; ENSDARP00000102789; ENSDARG00000077353 |
GeneIDi | 569081 |
Organism-specific databases
CTDi | 569081 |
ZFINi | ZDB-GENE-060718-1, rerea |
Phylogenomic databases
eggNOGi | KOG2133, Eukaryota |
GeneTreei | ENSGT00940000153615 |
HOGENOMi | CLU_005292_1_0_1 |
InParanoidi | E7F226 |
OrthoDBi | 136778at2759 |
PhylomeDBi | E7F226 |
TreeFami | TF328554 |
Gene expression databases
Bgeei | ENSDARG00000077353, Expressed in embryo and 35 other tissues |
ExpressionAtlasi | E7F226, baseline |
Family and domain databases
CDDi | cd00202, ZnF_GATA, 1 hit |
Gene3Di | 2.30.30.490, 1 hit |
InterProi | View protein in InterPro IPR002951, Atrophin-like IPR001025, BAH_dom IPR043151, BAH_sf IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR001005, SANT/Myb IPR017884, SANT_dom IPR000679, Znf_GATA |
Pfami | View protein in Pfam PF03154, Atrophin-1, 1 hit PF01426, BAH, 1 hit PF01448, ELM2, 1 hit PF00320, GATA, 1 hit |
SMARTi | View protein in SMART SM00439, BAH, 1 hit SM01189, ELM2, 1 hit SM00717, SANT, 1 hit SM00401, ZnF_GATA, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS51038, BAH, 1 hit PS51156, ELM2, 1 hit PS51293, SANT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E7F226_DANRE | |
Accessioni | E7F226Primary (citable) accession number: E7F226 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | January 19, 2022 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |