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Entry version 70 (07 Oct 2020)
Sequence version 1 (08 Mar 2011)
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Protein
Submitted name:

Upregulator of cell proliferation

Gene

urgcp

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Upregulator of cell proliferationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:urgcpImported
Synonyms:si:dkey-204a24.10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-120215-160, urgcp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation, NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7F219

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000036767, Expressed in pharyngeal gill and 6 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 95Fibronectin type-IIIInterPro annotationAdd BLAST86
Domaini96 – 190Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini848 – 1090VLIG-type GInterPro annotationAdd BLAST243

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili679 – 706Sequence analysisAdd BLAST28
Coiled coili746 – 769Sequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSGY, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154390

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002276_3_0_1

Database of Orthologous Groups

More...
OrthoDBi
418635at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E7F219

TreeFam database of animal gene trees

More...
TreeFami
TF335271

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR030383, G_VLIG_dom
IPR015894, Guanylate-bd_N
IPR013783, Ig-like_fold
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 2 hits
PF02263, GBP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 2 hits
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 2 hits
PS51717, G_VLIG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7F219-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDPGESTAI EDQIRITDVG PHSVRLAWGA AGVTANKQQK FQVEWKNEGI
60 70 80 90 100
HFTKTTDANH FEIKQLTPGT RYNITVLETE ESCQSFSASV CTAIPAPENF
110 120 130 140 150
EYVAMDATTV RLNWTSPPEM DPSFYKFQVI MYKNKEKTES VTMKSDLNTI
160 170 180 190 200
VMIDLLPATE YKATINTILE DDKQSKPVAL IVHTQPLPPT NLQIKNEATS
210 220 230 240 250
VTLKWTDPIT DDKIPHRFRV ICSGEANRME MFTDEEEINV SGLSPGMEYS
260 270 280 290 300
FSVYTLVKLN DTELESTSVK VTQRTNINME YMLMELGLQS HLKNKLTLKS
310 320 330 340 350
VLELRRMSDE NQAQSFKDLS WLFLRKLMMV NSSARSIKCA NTSTEDQKGV
360 370 380 390 400
NPLDLITALF HCADPFLQQE MALKMSLCQF SVPLLLPNCD TKECTLMLWA
410 420 430 440 450
LRDITKQFRS HSLRKDCSGE NSIVQTDFPL ISFVRLGKGK LSKSEFLNKL
460 470 480 490 500
ISNNQQNHDT FVHWKIANGN FPRKICNGLV EMTWYLPCGK ETDKFKEPIA
510 520 530 540 550
VANLRGDISE FEVQLAFLSQ VSSAVFLFCD DLDSNQTLLN SLQLSKLVLV
560 570 580 590 600
CNTNDLESRN DLEKSLAELT LNTHSVIFKD VKMNDDDFVA KLQMTVDEIL
610 620 630 640 650
KHSTSVSIKK MSEIAPDLGI LVDENDDICQ NAKKMAETMT KDIDDISQFK
660 670 680 690 700
IRQLPLQGEK LKEVSELEKE MCRLRKAKKQ NIEHYKDELR SRIHKLKMEQ
710 720 730 740 750
ENSNMKQVIS LFISGLCCSS KFQMYFLKWM KIMLDSLTRQ HLSSLDEQYK
760 770 780 790 800
EACKKARKEK EHLRKLENHI ANSSLGVQHF MRELSQLYES AHSHETWKNP
810 820 830 840 850
ALKNLPKVCA QLMLNGFPLE LVDGEASNIP LTWIGDVLTA LNKLTAPHNK
860 870 880 890 900
IRVITVLGVQ STGKSTLLNT MFGVQFAVSS GRCTRGAFML LLGVSEEFRA
910 920 930 940 950
ELQCDYLLVI DTEGLKSLEL AKLADSYEHD NELATLVVGL SDITIVNLAM
960 970 980 990 1000
ENAAEMKDTL QIVVHAFLRM KEVGKKPCCH FAHQNAADVA VHDKTLRERM
1010 1020 1030 1040 1050
SFFQQLDVMT QAAAKMEKKS SNYTFTDILE YNIDGNNWYI PGLWLGTPPM
1060 1070 1080 1090 1100
APVNTGYSEG VNKFKHGILD ILKKTKVPAQ DFVAFAEWIR SLWKAVQFES
1110 1120 1130 1140 1150
FIFSFRNSLI AEAYSKLCAE FNTWEWVFRK HMIDWCTKSE TKITNMGAVS
1160 1170 1180 1190 1200
AQSGDAVNLD RVLAALKCEA DNELGKKEKS LLDSIQQYFE SELEHAHLVE
1210 1220 1230 1240 1250
DHKEDFLNSA RGIRKEVQTD IHIKLENAIL IQKGIEKVEL IKQKQRDTMK
1260 1270 1280 1290 1300
EKVLNLIQVC RSRTNKLCDS ELNGEFEKIW NDIVKQNSFS ALPRQDVVKE
1310 1320 1330 1340 1350
TYRLLHSNLE MKSGAVREML STVTSLDQCG IGPFFAVAKA HFFTRFRNSL
1360 1370 1380 1390 1400
RPAERNKKHR LIQLACDKII NESEIFIKNK TEPKSDYNSA DIQELLCFID
1410 1420 1430 1440 1450
KNLESCKDPQ ISPEVEAALK IHICGNAARA FQKMHDDYLQ KNDPLKSLQL
1460 1470 1480 1490 1500
FKKEWLADFK DLYYERDQCQ NKAEMCAMQC FAPAVMEYIQ KRLGPDIVDE
1510 1520 1530 1540 1550
MLSGERGLEF CTRSFFQCSL LKQLLWDDNF DNILEYVRNY ESFVTKWISE
1560 1570 1580 1590 1600
RITEHFSKKG ALSKLEVKHL NDIINKIKEA VESVQKVAGV PTNICRFVTN
1610 1620 1630 1640 1650
VCKNLNKELV IQTDTLNATL TLNNSNPAEF IDCFKSSIDK MHKRLVDQLH
1660 1670 1680 1690 1700
AETNARDKLT RLSVNKPQEV LFNRVFGCGK KCPFCMAPCE AGGKRHTNHF
1710 1720 1730 1740 1750
VSIHRPQGIG YYSWVTNNKL IADICSSLVA SEMTFRHEDT GFQWYPYKEY
1760 1770 1780 1790 1800
RQFYPNWRIQ PDSSIEATDY WKYIFAKYNS KFAAQYNVKP ADIPDSWYRI
1810
SVQQANKCLE DTFKMKQ
Length:1,817
Mass (Da):208,098
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2DDD7FF14AF258B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR628394 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_001344701.4, XM_001344665.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000151384; ENSDARP00000126031; ENSDARG00000036767

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100005729

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:100005729

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628394 Genomic DNA No translation available.
RefSeqiXP_001344701.4, XM_001344665.6

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiE7F219

Genome annotation databases

EnsembliENSDART00000151384; ENSDARP00000126031; ENSDARG00000036767
GeneIDi100005729
KEGGidre:100005729

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55665
ZFINiZDB-GENE-120215-160, urgcp

Phylogenomic databases

eggNOGiENOG502QSGY, Eukaryota
GeneTreeiENSGT00940000154390
HOGENOMiCLU_002276_3_0_1
OrthoDBi418635at2759
PhylomeDBiE7F219
TreeFamiTF335271

Gene expression databases

BgeeiENSDARG00000036767, Expressed in pharyngeal gill and 6 other tissues

Family and domain databases

CDDicd00063, FN3, 3 hits
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR030383, G_VLIG_dom
IPR015894, Guanylate-bd_N
IPR013783, Ig-like_fold
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00041, fn3, 2 hits
PF02263, GBP, 1 hit
SMARTiView protein in SMART
SM00060, FN3, 3 hits
SUPFAMiSSF49265, SSF49265, 2 hits
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50853, FN3, 2 hits
PS51717, G_VLIG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F219_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F219
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: October 7, 2020
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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