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UniProtKB - E7F114 (E7F114_DANRE)

Entry version 81 (19 Jan 2022)
Sequence version 3 (20 Jun 2018)
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Protein
Submitted name:

SEC31 homolog B, COPII coat complex component

Gene

sec31b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transportARBA annotation, Protein transportARBA annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
SEC31 homolog B, COPII coat complex componentImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sec31bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-060418-2, sec31b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulumARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000002916, Expressed in multi-cellular organism and 27 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000008006

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati117 – 159WDPROSITE-ProRule annotationAdd BLAST43
Repeati255 – 297WDPROSITE-ProRule annotationAdd BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini579 – 702Sec16_CInterPro annotationAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni796 – 911DisorderedSequence analysisAdd BLAST116
Regioni923 – 1015DisorderedSequence analysisAdd BLAST93

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili723 – 743Sequence analysisAdd BLAST21
Coiled coili1091 – 1114Sequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat SEC31 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0307, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003175

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003033_1_0_1

Database of Orthologous Groups

More...OrthoDBi		100998at2759

TreeFam database of animal gene trees

More...TreeFami		TF313842

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024298, ACE1_Sec16_Sec31
IPR040251, SEC31-like
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR13923, PTHR13923, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12931, Sec16_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00320, WD40, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E7F114-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVKEILRTA TQAWSPARQH PAYLALGTAA QQLDASFNTS SALEIFDMDF 
        60         70         80         90        100
SDTSMDMKLR GTLATSNRFH SLIWVAFGMD VQPSSGRLIG GSENGSVTVF 
       110        120        130        140        150
NPDVILTAGE DAVIGQSNKH TGPVRALDFN RFQSNLIASG ANDSEIYIWD 
       160        170        180        190        200
LNNFSNPMTP GTKSQPAEDV SVVAWNSQVQ HILASANPSG KAVVWDLRKN 
       210        220        230        240        250
EPIIKISDHS NRMHCSGMLW HPDVATQLVL ASEDDRLPVI QMWDLRFATS 
       260        270        280        290        300
PLKVLENHTR GILSISWSQA DPELLLSSGK DNRILCWNPN TGEVIYELPT 
       310        320        330        340        350
ANQWCFDVQW CPRNPALLSA ASFDGRISVY SVMGGRLQQQ QHSTVDQISA 
       360        370        380        390        400
SFDTNDPFGM GQTLPPLQVP QAAVETTIIP PLKKPPKWVR RPVGASFAFG 
       410        420        430        440        450
GKLVTFENPN VAPPQQQQPA NPLPRQVHVS QVTTETEFLQ RSTELQMTLQ 
       460        470        480        490        500
SGSFSSFCHS KIQSAPTDAE QDIWRFLMVN FEDEARVKFL RLLGFSKDEL 
       510        520        530        540        550
QRKISACLGR KLQPNGLDVN DLAEKMQTLS DQRADECAGA ADGLPGRESP 
       560        570        580        590        600
ADFFSQLPKK EKDKQPFQIP VSSDTDGLIS QALLVGNFEG AVDLCLNDGR 
       610        620        630        640        650
FAEAILLSIS GGEELLKKTQ QRYLQRQTNS ISMLISSVVT QNWRDIVQSC 
       660        670        680        690        700
ELDNWKEALA ALLTYANPEE FASLCDTLGS RLEAGGSEKL CLQACLCFIC 
       710        720        730        740        750
SGNIERLVDC WTLQRDCSSP LALEDLVEKV MILRKSIERL RNIEVCVRSS 
       760        770        780        790        800
ALTQKLIQYS SILASQGSLS AALNYLPSDS DQAAVRMLRD RLSHAKGEIQ 
       810        820        830        840        850
QKPSAPAGGA KPAPNTHTPA AHTTAPYPSS GAPQMPRLFS PQTGPEPPAG 
       860        870        880        890        900
ATTHTPRPAY TQHPATAPGF HPFPPAAPQG APGGFFTPQM PSSSLAGPSM 
       910        920        930        940        950
PPSSPPGPMM PAGVPMMMPT PPAPGFLSPT SLPGGPRFPG SAHTQGPAPP 
       960        970        980        990       1000
PTGAYPSLGA AGYPQGGPGA PAAKSFSGAP VPPPPSGAQD GWNDPPAVRA 
      1010       1020       1030       1040       1050
GQRKKKLPEN YTPPAPITAP VMGFPAEAPV LQDRVQVPPG APQEPSIQSI 
      1060       1070       1080       1090       1100
QQLPAERVEQ KEIPAEHMIL KTTFSSLVQR CQLAAADPQT KRKLDDASKR 
      1110       1120       1130       1140       1150
LENLYDKLRD QSLSPSILGG LHEISRCVSA RSYVQGLEVH TQVVSSSNFS 
      1160       1170 
EISAFMPVLK VLMTIANKLA V
Length:1,171
Mass (Da):126,693
Last modified:June 20, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7906FE3F520F0C0D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3JA82U3JA82_DANRE
SEC31 homolog B, COPII coat complex...
sec31b
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CT583693 Genomic DNA No translation available.
FP017284 Genomic DNA No translation available.
FP102054 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_001921581.3, XM_001921546.6

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000014190; ENSDARP00000008006; ENSDARG00000002916
ENSDART00000153126; ENSDARP00000127134; ENSDARG00000002916

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100148383

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:100148383

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT583693 Genomic DNA No translation available.
FP017284 Genomic DNA No translation available.
FP102054 Genomic DNA No translation available.
RefSeqiXP_001921581.3, XM_001921546.6

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000008006

Genome annotation databases

EnsembliENSDART00000014190; ENSDARP00000008006; ENSDARG00000002916
ENSDART00000153126; ENSDARP00000127134; ENSDARG00000002916
GeneIDi100148383
KEGGidre:100148383

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25956
ZFINiZDB-GENE-060418-2, sec31b

Phylogenomic databases

eggNOGiKOG0307, Eukaryota
GeneTreeiENSGT00390000003175
HOGENOMiCLU_003033_1_0_1
OrthoDBi100998at2759
TreeFamiTF313842

Gene expression databases

BgeeiENSDARG00000002916, Expressed in multi-cellular organism and 27 other tissues

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR024298, ACE1_Sec16_Sec31
IPR040251, SEC31-like
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR036322, WD40_repeat_dom_sf
PANTHERiPTHR13923, PTHR13923, 1 hit
PfamiView protein in Pfam
PF12931, Sec16_C, 1 hit
SMARTiView protein in SMART
SM00320, WD40, 6 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F114_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F114
Secondary accession number(s): U3JA69
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: June 20, 2018
Last modified: January 19, 2022
This is version 81 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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