Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 73 (29 Sep 2021)
Sequence version 1 (08 Mar 2011)
Previous versions | rss
Add a publicationFeedback
Protein

TBC1 domain family member 31

Gene

tbc1d31

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 31ARBA annotation
Alternative name(s):
WD repeat-containing protein 67ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tbc1d31Imported
Synonyms:wdr67Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-061218-4, tbc1d31

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7F0J3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000074623, Expressed in early embryo and 26 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000099918

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini419 – 594Rab-GAP TBCInterPro annotationAdd BLAST176

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni953 – 1034DisorderedSequence analysisAdd BLAST82

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili690 – 710Sequence analysisAdd BLAST21
Coiled coili722 – 766Sequence analysisAdd BLAST45
Coiled coili816 – 836Sequence analysisAdd BLAST21
Coiled coili892 – 922Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi973 – 1003Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi1010 – 1025Polar residuesSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0295, Eukaryota
KOG1093, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153859

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003330_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E7F0J3

Identification of Orthologs from Complete Genome Data

More...
OMAi
WFEYHPL

Database of Orthologous Groups

More...
OrthoDBi
858041at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E7F0J3

TreeFam database of animal gene trees

More...
TreeFami
TF324799

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00566, RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47923, SSF47923, 1 hit
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50086, TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7F0J3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVTDIGSRE DGKIWHRKSV SKNGVLATVI RNSSARQTKT VRFLQVAFDT
60 70 80 90 100
TGESFLAGDH HGNIYVFDIC RNRFKLVQKT GQACTALAFN LRRTTEFLVA
110 120 130 140 150
LADYSIKCFD KDTRQLVSWM RGHEGAVSSL SIHSSGSFAI STSSDTAQLW
160 170 180 190 200
SLDTFQRKRK LNVRQSVGIQ KVFFLPHSNT ILSCFSDNSI FAWETDTLFC
210 220 230 240 250
KYQLPVPQNG PRIHYRTFAV TQNGKTLAAA GRSNLVHLWC LDSQQLIRVI
260 270 280 290 300
QMPSNVKTVR YLDFLPDSFD DGSNQTLGVL SQDGIMRFVN IQSCKQLFLI
310 320 330 340 350
GSHEDAISSA TVCPKGHHIV AVMDSGAIKI YDVRSLTTEI SKPPQPLLKR
360 370 380 390 400
VTKVNISDGS CLKMKVNTGA GQRAVKTSGR RIQSKLLPPS VSTLDDKEND
410 420 430 440 450
LPNGLSKKRL QALLREFGEY PAKYRMFIWR SLLRLPENHA AFSSLTDKGL
460 470 480 490 500
HSAFLCLQEQ YPIKSHKLQR GLQRVLSALA HWAAVFGETD YVPLLAFPFV
510 520 530 540 550
KLFQNNPLIC FEAVATVIVN WCQHWFEYFP NPPLNVLSLA ENVLAHHDKE
560 570 580 590 600
LLQHFVACGV TSQLYAWPLL ETLFSEVLMR EEWLKLFDNV FSNHPSFLLM
610 620 630 640 650
AVVAYVTCCR APLLLCTDKR DFEYFFHHRN SLDIGAMLKE TYRLMDRTPA
660 670 680 690 700
DIHPSSALND FEPLTQGQYP VFNKYPTFIV EYQSQERERI RQQEVEYLRE
710 720 730 740 750
RQEVQKLHAE AVRQQAEFEA WYKQQELLLQ GEEQRRLILQ EEESKLAQQR
760 770 780 790 800
ARLAAMKREL KVKELSLIDS SRRRFLKHQQ DQRRVHLKRL DDEIQRKMAL
810 820 830 840 850
RDQETAAAVQ EVEVRQMELD AQRQLFEQQL AREQERVSQE VRAEVDTRSR
860 870 880 890 900
RAEADHYTFQ NFILADADIS QKNQKMLVEE SLAEAGQMEV DADWQAEVIK
910 920 930 940 950
RLEEAKERQE KQRERLVNLG KQTRDKEDKV VQLMQEVEGK QWDDIVAKQA
960 970 980 990 1000
EREDKRWAAT SVTTQPRSFI SQETEEIEQH SKPHKTLDDS LNPQKEKRRR
1010 1020 1030 1040 1050
SPCSSRGLLY KPTDISSNNQ SDFSLDRNRG ELDSKERELM QEIRELRMKL
1060 1070
AARARATDFI SASASSIHSH
Length:1,070
Mass (Da):123,286
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F5205B69146F231
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX571853 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_695006.1, XM_689914.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000114528; ENSDARP00000099918; ENSDARG00000074623

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
563134

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:563134

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571853 Genomic DNA No translation available.
RefSeqiXP_695006.1, XM_689914.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000099918

Proteomic databases

PaxDbiE7F0J3

Genome annotation databases

EnsembliENSDART00000114528; ENSDARP00000099918; ENSDARG00000074623
GeneIDi563134
KEGGidre:563134

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
93594
ZFINiZDB-GENE-061218-4, tbc1d31

Phylogenomic databases

eggNOGiKOG0295, Eukaryota
KOG1093, Eukaryota
GeneTreeiENSGT00940000153859
HOGENOMiCLU_003330_0_0_1
InParanoidiE7F0J3
OMAiWFEYHPL
OrthoDBi858041at2759
PhylomeDBiE7F0J3
TreeFamiTF324799

Gene expression databases

BgeeiENSDARG00000074623, Expressed in early embryo and 26 other tissues

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00566, RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00320, WD40, 7 hits
SUPFAMiSSF47923, SSF47923, 1 hit
SSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50086, TBC_RABGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7F0J3_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7F0J3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 29, 2021
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again