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UniProtKB - E7F079 (E7F079_DANRE)
Protein
Heme oxygenase (biliverdin-producing)
Gene
hmox2b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalytic activityi
- heme b + 3 O2 + 3 reduced [NADPH—hemoprotein reductase] = biliverdin IXα + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH—hemoprotein reductase]ARBA annotationEC:1.14.14.18ARBA annotation
GO - Molecular functioni
- heme binding Source: GO_Central
- heme oxygenase (decyclizing) activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- heme catabolic process Source: GO_Central
- heme oxidation Source: GO_Central
- iron ion homeostasis Source: GO_Central
- response to oxidative stress Source: GO_Central
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Ligand | HemeARBA annotation, Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.14.14.18, 928 |
Reactomei | R-DRE-189483, Heme degradation R-DRE-6798695, Neutrophil degranulation R-DRE-8980692, RHOA GTPase cycle R-DRE-917937, Iron uptake and transport R-DRE-9707564, Cytoprotection by HMOX1 |
Names & Taxonomyi
Protein namesi | Recommended name: Heme oxygenase (biliverdin-producing)ARBA annotation (EC:1.14.14.18ARBA annotation) |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-091118-52, hmox2b |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 300 – 317 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSDARG00000078452, Expressed in retina and 25 other tissues |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 25 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 18 | Polar residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the heme oxygenase family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG4480, Eukaryota |
GeneTreei | ENSGT00390000017673 |
InParanoidi | E7F079 |
OrthoDBi | 1424194at2759 |
TreeFami | TF314786 |
Family and domain databases
CDDi | cd19165, HemeO, 1 hit |
Gene3Di | 1.20.910.10, 1 hit |
InterProi | View protein in InterPro IPR002051, Haem_Oase IPR016053, Haem_Oase-like IPR016084, Haem_Oase-like_multi-hlx IPR018207, Haem_oxygenase_CS |
PANTHERi | PTHR10720, PTHR10720, 1 hit |
Pfami | View protein in Pfam PF01126, Heme_oxygenase, 1 hit |
PRINTSi | PR00088, HAEMOXYGNASE |
SUPFAMi | SSF48613, SSF48613, 1 hit |
PROSITEi | View protein in PROSITE PS00593, HEME_OXYGENASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
E7F079-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSAVRTEDAA NGTSTANGGG GVKCEEGGVT VLRPTDLSEM LAAGTKEVHQ
60 70 80 90 100
KAENTEFVKD FLRGRIRKEL FKLGHVALYF TYSALEEEIE RNKDHPQFAP
110 120 130 140 150
LYFPHELHRR DALAQDLQFF YGSDWQTQIS ISPATQRYVQ RIHQIGKDEP
160 170 180 190 200
ALLVAHAYTR YMGDLSGGQV LRKVAQRALK LPASGDGLNF YMFDNVSNAK
210 220 230 240 250
AFKQLYRSRM NELELQQDTK LKIVEEAVLA FQFNIEIFEE IGEVGQTLED
260 270 280 290 300
DVFDAAPVHG EMQGDISQCP YHAAKMAASG GSSYVCQIAK TVLKNPSGQV
310
LLAAWIAALA GLAAWYLM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9QDN3 | E9QDN3_DANRE | Heme oxygenase (biliverdin-producin... | hmox2b si:dkey-254e1.2 | 287 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005285 Genomic DNA No translation available. CT573469 Genomic DNA No translation available. |
RefSeqi | XP_002661145.1, XM_002661099.4 XP_005168529.1, XM_005168472.3 |
Genome annotation databases
Ensembli | ENSDART00000112800; ENSDARP00000104304; ENSDARG00000078452 ENSDART00000183778; ENSDARP00000151331; ENSDARG00000117010 |
GeneIDi | 100329531 |
KEGGi | dre:100329531 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX005285 Genomic DNA No translation available. CT573469 Genomic DNA No translation available. |
RefSeqi | XP_002661145.1, XM_002661099.4 XP_005168529.1, XM_005168472.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000104304 |
Proteomic databases
PaxDbi | E7F079 |
Genome annotation databases
Ensembli | ENSDART00000112800; ENSDARP00000104304; ENSDARG00000078452 ENSDART00000183778; ENSDARP00000151331; ENSDARG00000117010 |
GeneIDi | 100329531 |
KEGGi | dre:100329531 |
Organism-specific databases
CTDi | 100329531 |
ZFINi | ZDB-GENE-091118-52, hmox2b |
Phylogenomic databases
eggNOGi | KOG4480, Eukaryota |
GeneTreei | ENSGT00390000017673 |
InParanoidi | E7F079 |
OrthoDBi | 1424194at2759 |
TreeFami | TF314786 |
Enzyme and pathway databases
BRENDAi | 1.14.14.18, 928 |
Reactomei | R-DRE-189483, Heme degradation R-DRE-6798695, Neutrophil degranulation R-DRE-8980692, RHOA GTPase cycle R-DRE-917937, Iron uptake and transport R-DRE-9707564, Cytoprotection by HMOX1 |
Gene expression databases
Bgeei | ENSDARG00000078452, Expressed in retina and 25 other tissues |
Family and domain databases
CDDi | cd19165, HemeO, 1 hit |
Gene3Di | 1.20.910.10, 1 hit |
InterProi | View protein in InterPro IPR002051, Haem_Oase IPR016053, Haem_Oase-like IPR016084, Haem_Oase-like_multi-hlx IPR018207, Haem_oxygenase_CS |
PANTHERi | PTHR10720, PTHR10720, 1 hit |
Pfami | View protein in Pfam PF01126, Heme_oxygenase, 1 hit |
PRINTSi | PR00088, HAEMOXYGNASE |
SUPFAMi | SSF48613, SSF48613, 1 hit |
PROSITEi | View protein in PROSITE PS00593, HEME_OXYGENASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | E7F079_DANRE | |
Accessioni | E7F079Primary (citable) accession number: E7F079 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | January 19, 2022 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |