IQ motif and Sec7 domain ArfGEF 1b

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ARF guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processⁱ

• actin cytoskeleton organization Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• angiogenesis Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Brag2 differentially regulates beta1- and beta3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis."
    Manavski Y., Carmona G., Bennewitz K., Tang Z., Zhang F., Sakurai A., Zeiher A.M., Gutkind J.S., Li X., Kroll J., Dimmeler S., Chavakis E.
    Basic Res Cardiol 109:404-404(2014) [PubMed] [Europe PMC] [Abstract]
• lymphangiogenesis Source: ZFINInferred from mutant phenotypeⁱ
  • "Brag2 differentially regulates beta1- and beta3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis."
    Manavski Y., Carmona G., Bennewitz K., Tang Z., Zhang F., Sakurai A., Zeiher A.M., Gutkind J.S., Li X., Kroll J., Dimmeler S., Chavakis E.
    Basic Res Cardiol 109:404-404(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of GTPase activity Source: InterPro
• regulation of ARF protein signal transduction Source: InterPro
• vasculature development Source: ZFIN <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Brag2 differentially regulates beta1- and beta3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis."
    Manavski Y., Carmona G., Bennewitz K., Tang Z., Zhang F., Sakurai A., Zeiher A.M., Gutkind J.S., Li X., Kroll J., Dimmeler S., Chavakis E.
    Basic Res Cardiol 109:404-404(2014) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• ARF guanyl-nucleotide exchange factor activity Source: InterPro

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MDGHFAYIDM ENPTENPSKA AEYLKELNKI IETQQELLEK QKNRIEELEQ 
        60         70         80         90        100
QVCDLCQENA CLKDQHQRHL ATCRLQQQGN SHPTLGAIKE NVIQEKNESE 
       110        120        130        140        150
GLRVSNVRRH ASLPLDVTDN PGNFIVSHCQ RSYPCRKWKS ASLGVEGEAP 
       160        170        180        190        200
GGESGPSLDN SGGYLRGPVS RSAIISGEHF DGPPLYAHEV RQRPRRPKLQ 
       210        220        230        240        250
HSQSILRKQA EEEAIKRSRS LSESYELSTD LQDKQVEMLE RKYGGRFITR 
       260        270        280        290        300
HAARTIQTAF RQYQMNKNFE RLRSSMSENR MSRRIVLSNM RMQFSFEGPE 
       310        320        330        340        350
KVHSSYFEGK QVSLTDDGSK LGALVQSERG EMVPANMKSP AVQSDFTDAI 
       360        370        380        390        400
TELEDVFSRQ VKSLAESIDD ALNCRSLHGD EGQSEATRGH PDLEQEVTYQ 
       410        420        430        440        450
VKPSHGSEHR KRDEMTASYS DVTLYIDEEE LSPPLPLSQS VDRPSSTESD 
       460        470        480        490        500
LRLRSLNSSQ DYWSLAHKDE KADTDTSCRS TPSLECQEQR LRIDHLPLLT 
       510        520        530        540        550
IEPPSDSSVE LSDRSDRSSL KRQNAYDRGI ASQQGSPKHI PSHALPPRGP 
       560        570        580        590        600
AREDEAPRHR PRQLESHLAI NGTANRQSKS ESDFSDGDND SINSTSNSND 
       610        620        630        640        650
TINCSSESSS RDSLREQTLS KQTYHKETRN SWDSPAFSND IIRKRHYRIG 
       660        670        680        690        700
LNLFNKKPEK GIQYLIERGF VPDTPVGVAH FLLQRKGLSR QMIGEFLGNR 
       710        720        730        740        750
QKQFNRDVLD CVVDEMDFSA MELDEALRKF QAHIRVQGEA QKVERLIEAF 
       760        770        780        790        800
SQRYCICNPG VVRQFRNPDT IFILAFAIIL LNTDMYSPNV KPERKMKLED 
       810        820        830        840        850
FVKNLRGVDD GEDIPREMLV GIYERIRKRE LKTNEDHVSQ VQKVEKLIVG 
       860        870        880        890        900
KKPIGSLHHG LGCVLSLPHR RLVCYCRLFE VPDPNKPQKL GLHQREIFLF 
       910        920        930        940        950
NDLLVVTKIF QKKKNSVTYS FRQSFSLYGM QVLLFENQYY PNGVRLTSAL 
       960        970        980        990       1000
PGADIKVLIN FNAPNPQDRK KFTDDLRESI AEVQEMEKYR IESELEKQKG 
      1010       1020       1030       1040       1050
VVRPSISQSS GLKKETGNGN LSRTSLDDSY AMGEGLKRSA LSSSLRDLSD 
      1060       1070       1080       1090       1100
AGKRGRRSSA GSLDSNMEGS IISSPHIRRR ATSSRDCPSR QQSIPNSSSL 
      1110       1120       1130       1140       1150
LGSLFGTKRG KSPSLPSQSS HPSHPTLISH TPHPSNLHHT ARDGVTVTET 
      1160       1170       1180       1190       1200
QAQMHPHHAQ FCHMQNPPPY HHHHHYHPPA HIQHPPHQYH PPPGPSSSHS 
      1210       1220       1230       1240       1250
HSHSQHGHGP HPSHSSHPSH SQHAPHHHSQ PPAPPPAASS TKPKHSGIST 

VV                                                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ