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Entry version 74 (13 Nov 2019)
Sequence version 3 (20 Jun 2018)
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Protein
Submitted name:

Spectrin repeat-containing, nuclear envelope 1b

Gene

syne1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Spectrin repeat-containing, nuclear envelope 1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:syne1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-071218-4 syne1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8659CytoplasmicPROSITE-ProRule annotationAdd BLAST8659
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8657 – 8678HelicalSequence analysisAdd BLAST22
Topological domaini8681 – 8710Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
E7EZ30

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000063068 Expressed in 22 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7EZ30 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000086261

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 134Calponin-homology (CH)InterPro annotationAdd BLAST108
Domaini178 – 283Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini8651 – 8710KASHInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni6108 – 6129DisorderedSequence analysisAdd BLAST22
Regioni8163 – 8190DisorderedSequence analysisAdd BLAST28
Regioni8210 – 8231DisorderedSequence analysisAdd BLAST22
Regioni8580 – 8619DisorderedSequence analysisAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili11 – 31Sequence analysisAdd BLAST21
Coiled coili229 – 249Sequence analysisAdd BLAST21
Coiled coili310 – 330Sequence analysisAdd BLAST21
Coiled coili612 – 632Sequence analysisAdd BLAST21
Coiled coili765 – 785Sequence analysisAdd BLAST21
Coiled coili1219 – 1239Sequence analysisAdd BLAST21
Coiled coili1249 – 1317Sequence analysisAdd BLAST69
Coiled coili1362 – 1389Sequence analysisAdd BLAST28
Coiled coili1537 – 1557Sequence analysisAdd BLAST21
Coiled coili1605 – 1632Sequence analysisAdd BLAST28
Coiled coili1675 – 1702Sequence analysisAdd BLAST28
Coiled coili1969 – 1989Sequence analysisAdd BLAST21
Coiled coili2003 – 2023Sequence analysisAdd BLAST21
Coiled coili2157 – 2177Sequence analysisAdd BLAST21
Coiled coili2226 – 2246Sequence analysisAdd BLAST21
Coiled coili2260 – 2287Sequence analysisAdd BLAST28
Coiled coili2324 – 2351Sequence analysisAdd BLAST28
Coiled coili2421 – 2441Sequence analysisAdd BLAST21
Coiled coili2812 – 2832Sequence analysisAdd BLAST21
Coiled coili2924 – 2969Sequence analysisAdd BLAST46
Coiled coili3141 – 3161Sequence analysisAdd BLAST21
Coiled coili3169 – 3206Sequence analysisAdd BLAST38
Coiled coili3385 – 3405Sequence analysisAdd BLAST21
Coiled coili3446 – 3466Sequence analysisAdd BLAST21
Coiled coili3498 – 3518Sequence analysisAdd BLAST21
Coiled coili3566 – 3586Sequence analysisAdd BLAST21
Coiled coili3670 – 3690Sequence analysisAdd BLAST21
Coiled coili3764 – 3795Sequence analysisAdd BLAST32
Coiled coili3947 – 3967Sequence analysisAdd BLAST21
Coiled coili4116 – 4140Sequence analysisAdd BLAST25
Coiled coili4259 – 4279Sequence analysisAdd BLAST21
Coiled coili4401 – 4421Sequence analysisAdd BLAST21
Coiled coili4503 – 4523Sequence analysisAdd BLAST21
Coiled coili4690 – 4717Sequence analysisAdd BLAST28
Coiled coili4768 – 4795Sequence analysisAdd BLAST28
Coiled coili4898 – 4918Sequence analysisAdd BLAST21
Coiled coili5087 – 5118Sequence analysisAdd BLAST32
Coiled coili5133 – 5153Sequence analysisAdd BLAST21
Coiled coili5225 – 5252Sequence analysisAdd BLAST28
Coiled coili5281 – 5305Sequence analysisAdd BLAST25
Coiled coili5426 – 5453Sequence analysisAdd BLAST28
Coiled coili5650 – 5670Sequence analysisAdd BLAST21
Coiled coili5718 – 5745Sequence analysisAdd BLAST28
Coiled coili5756 – 5793Sequence analysisAdd BLAST38
Coiled coili5923 – 5943Sequence analysisAdd BLAST21
Coiled coili6145 – 6172Sequence analysisAdd BLAST28
Coiled coili6438 – 6458Sequence analysisAdd BLAST21
Coiled coili6500 – 6520Sequence analysisAdd BLAST21
Coiled coili6572 – 6592Sequence analysisAdd BLAST21
Coiled coili6969 – 6996Sequence analysisAdd BLAST28
Coiled coili7075 – 7105Sequence analysisAdd BLAST31
Coiled coili7724 – 7751Sequence analysisAdd BLAST28
Coiled coili8385 – 8405Sequence analysisAdd BLAST21
Coiled coili8420 – 8447Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154481

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E7EZ30

TreeFam database of animal gene trees

More...
TreeFami
TF329280

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014 CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR012315 KASH
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 2 hits
PF10541 KASH, 1 hit
PF00435 Spectrin, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033 CH, 2 hits
SM01249 KASH, 1 hit
SM00150 SPEC, 49 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS51049 KASH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E7EZ30-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLSPFGRS SKDIMNLMQK LQDEQESVQK RTFTKWINSH LAKHKPPFEV
60 70 80 90 100
NDLFEDIKDG VKLLALLEVL SGQRLPCEQG RQLKRIHWVS NIGTALKFLE
110 120 130 140 150
GRKIKLVNIN ATDIADGRPS IVLGLMWTII LYFQIEELTS NLPALQALSS
160 170 180 190 200
SASSVDSMAS SETGSPPMKR KVVTKFQGNA KRALLRWVQN TATKRLGIEV
210 220 230 240 250
KDFGASWRSG VAFHSVIHAI RPELVDMDVV RKRSNRENLE EAFSVAENEL
260 270 280 290 300
GIPRLLDPED VDVDKPDEKS IMTYVAQFLK HYPDPHQSET DGQQEEREER
310 320 330 340 350
KVLREVKIWL DQLERDVLRA QGSEESLTDK YQAFKSFRVQ YEMRKKQIES
360 370 380 390 400
LLQPVHRDGK LSVDQAVVKQ SWDHVSVRLL DWHIHLDKSL PGPLGVIGAW
410 420 430 440 450
LHRAELSLRE DVPIQQAHEE TANIIHRKLE QHKEVLKNLE GHRQTFQQIH
460 470 480 490 500
RDRSVNGVPV PPEQLQDMAE RFNFVTTSSH VHLIKFEFWE MKYRLMAFLM
510 520 530 540 550
LAESKLKSWI IKYGRRDSVE LLLQNYIVFI EGHKFFEQYE TTFRTLKQAA
560 570 580 590 600
DTYLKSGTSA EEVEGVNKFL SDATAQWKNL SVEVRSVRSM LEEVICNWEK
610 620 630 640 650
YSSTVASLQA WLEDAEKMLN QSESDKREFF RNLPHWIQQH MDMNDAGNFL
660 670 680 690 700
IETCDETVSR ELKQQLLLLN GRWRELFVKV KHYARADEVD KLRKDYDDGI
710 720 730 740 750
EALKAFIDTA NERMNTPVQV SFLNIRTYLQ DVEDIKHKVP SMEAAYKTAT
760 770 780 790 800
RNAQQLTKDL SEDEIAHMLN NMTNIKDELS KIRERALPLL RDSQAMLPPL
810 820 830 840 850
EEMEKNITGF YQSLEKASRI TSSRDSEAPG DFTQKCQELV TYQQSCKKCL
860 870 880 890 900
SVIDKNHQVI LKSLDTSKNL KHLDTSLLER RITELQASSQ GMVKETTEWK
910 920 930 940 950
QHVEANSSLM KRFEESRVEL EKVLKIARSS MTERGNPEDL LKKHTEFFGQ
960 970 980 990 1000
LDQRVLNAFL KACDELTDIL PEQEQQNLQE TVRKLHKQWK DVQTEFPYHL
1010 1020 1030 1040 1050
LHLKVDLEKS RLMTSLQECQ AELARENRSL PSVGSERLIK EHRMFFKEKG
1060 1070 1080 1090 1100
PQALCEKRLQ HMDELCLKLP ESQQAQQTLV IARTAFAEVK EEIDSTHQRL
1110 1120 1130 1140 1150
MQHPDKWKEF NTRFSELSAW VTSKESQLRL LRNRAGDPSK FGQVKSTIES
1160 1170 1180 1190 1200
LRNDAELQEG NVSWLKNRLA ALIEICTESD AQRQGAALSK LSNDFKGLLI
1210 1220 1230 1240 1250
SLSESEKVVL AVSDCVQFRE EVKTTLEELT QGQKELQSDN SKILDSESVR
1260 1270 1280 1290 1300
EAQQLLLLHQ QQLKRLRLKR KDMQEQINRG KQLQIEEGLE ESLQDDLQKL
1310 1320 1330 1340 1350
ESTLKKMDEN TESQEKNLEV TLSAWQEFDA QQASVREFVG KVRSVTEREM
1360 1370 1380 1390 1400
NFSSPESLSS ELEQTKDLLK QCETEVRQVN TLLKRATEIQ LGPKNQSLLQ
1410 1420 1430 1440 1450
DQARALSEQV DKVEKGLKRD VKTLEGMKSQ WDLFGSEFEA FSSWIMERER
1460 1470 1480 1490 1500
EMDALKSSSI PLDQQICTVQ TIRDGLQERS EVLSNLEEKS QSLVQFVSSG
1510 1520 1530 1540 1550
ESARIKARLT QIGRYWEELK ESVDHLSGQL EESSSHQTKF NSNLQQVQSE
1560 1570 1580 1590 1600
VEEIQKKLDN PVTSCISSSE TYKTLQSHMD VFQSLEKLKA TLLSLSAGAR
1610 1620 1630 1640 1650
RLSEREKAER AVAALQQNYE QCLKQAKEKQ NQTESLLSHW QKYEKDWSAL
1660 1670 1680 1690 1700
KSCLERCEAA CGPDSQSLPV DKLKLDGELL ELKHLQTELE SLEVVYNRLG
1710 1720 1730 1740 1750
AQTPSLYTTA SDERVKTLKE DHQQLEKRWM CQTTAIPHRI QVLQQHLSQV
1760 1770 1780 1790 1800
DQFDQALQKF FKWGESFLSS LHSSSHTDIT DLQPSTNDIK EKREALLKQS
1810 1820 1830 1840 1850
IVRQNLQQQT KTLCDVCEPA EVQHLQGRWE SSLQPYLEAH QLVELRGESL
1860 1870 1880 1890 1900
EKLEAFLHTH SVAAGVLQGL RQTVESAGSW DKSRVEELQR ELEAIVPDIS
1910 1920 1930 1940 1950
RLETLAVNLD GNLCKSHLHL MSGKETRSSC RSLADSLSAE LDAVRNLLGS
1960 1970 1980 1990 2000
KQSEAEALGA LWSSFRQRKE QLLKTVEDIE EKADQQGLKE PNVLTLQQRL
2010 2020 2030 2040 2050
RFFNQLEDEL QSHQHEEQWL RDKGQQLAHR DAELGSEVLR EINLLQTTWE
2060 2070 2080 2090 2100
DTKKLITERQ EQSSALVDLM KDYQTLKSSI NSILESADAI ADIKSVLKDQ
2110 2120 2130 2140 2150
EDTRRSLLKH EAVKADMASH QDVLDRFSSK GKKLLSELNK IPDCDTQIVK
2160 2170 2180 2190 2200
TEIDATVDQW LDVSEKIEDN LESLKRSSAL WVEIYDINGE IESWSNSSVM
2210 2220 2230 2240 2250
DLTDGLNNFN DSQKTAHKLS EVKVDVGLKE KKIDALQEKV SEMKQLCGGQ
2260 2270 2280 2290 2300
DVPAKLQVME TDLRRKLNSI EELCDQAKNN LQDFCCQKKQ LEDFLSQMSE
2310 2320 2330 2340 2350
WLMSVERSLV DSPCGTAPEE ICRVKEIQKE LQNQQASIDS ARESLNTLCR
2360 2370 2380 2390 2400
KYPSEELAGL GSSLTDLIKK YETVNQICVK RLGSMQHGLQ QHFNDLVKEF
2410 2420 2430 2440 2450
HTWLSGQKDI VRECADHSGD MSVVERKLQK LKGALERVED GDDRLTLVCT
2460 2470 2480 2490 2500
EGEKLLLHLP KASAGQVQQS LSSIQQDWDS YVEQCRQNQQ NLEDSASLLS
2510 2520 2530 2540 2550
GFDGRLQRLS RWLERMDVKM STELPEGRHG DQERVTLERV EEFQHEVLKE
2560 2570 2580 2590 2600
RDSFEGLCQE AQALSEGGHG SGSEVRASAQ LQHQHQSLLK AARERLRVCQ
2610 2620 2630 2640 2650
LSMQEQQNFQ ETLQSTWLWL SSAQERLTAL NSTGGNKETL EKRLALVQDI
2660 2670 2680 2690 2700
LLMKGEGEVK LNMTVGKGEQ VLKNCSRDKQ EVIRSQLKSL KDSWANILMT
2710 2720 2730 2740 2750
AMSCHSRLEW TVAQWSSFQE SKAQLQQWLE MVEQEAGVAL PQQPGLKEKA
2760 2770 2780 2790 2800
ALLERLRVIQ ADVEVHSTAL SRLNEKATEL YEKTGDQAFA ERPKSDFNTQ
2810 2820 2830 2840 2850
FTNITAVIKS KVQQMEEIVK EHEQYMESVR DLNDWLTSAK EELQRWSDMS
2860 2870 2880 2890 2900
GDAASVQRKL SKVRGLLDSR KQGRERLTRV QSCGAATRDH TSTVGCEVLE
2910 2920 2930 2940 2950
REEAGLLSAW EQWERGAKHV CSGLEGVLAQ MANSEQEFNS LAAQLEQDLQ
2960 2970 2980 2990 3000
EFSSKLQEWR IKLQQVEEMS AGEEAVQGWQ IAKDTLEALQ NVEPMSDNLK
3010 3020 3030 3040 3050
CQLNDLCRFS RDLGAQSERV SALIKEYNSL SLQASRECQG KEKLLEQRFR
3060 3070 3080 3090 3100
AAFRDFQQWL VNAKINTAKC FDVPQNLAEA SSSLQKIQEF LSDREQGQGK
3110 3120 3130 3140 3150
LNTVAASGEL LMSIAAKDRV ESVRAKINSA REDWKTLMTN LHQRENALQN
3160 3170 3180 3190 3200
LQAQMRDFET SVEPLQDWLN DTEEAVQESS SRLQDLTAKK QELHRLQSLL
3210 3220 3230 3240 3250
EELASKEPQL LRLREKAQQL WDGHTAGKGF VHRVSQLSAQ YLALSNLTKE
3260 3270 3280 3290 3300
KASRIERVVS EHQLFSQGLK ELQNWVSDTS HMLQTYCTPT ADKNVLDSRM
3310 3320 3330 3340 3350
IKLEALLTAR QEKEIQLKML LTRGESVQRN TSADGVPLVR QQIEDLKDSW
3360 3370 3380 3390 3400
DGLLSASIQC KSQLEGALSQ WTSYQEDVRQ FVSWMETVEE TLSSADKQCS
3410 3420 3430 3440 3450
EMRDKTTNLG KAKLLLEDVL SHNSVLDVIS MKGSNMAEHY VTQLEIQDLQ
3460 3470 3480 3490 3500
ERYNIVKDKA QCAVAKAEEL VSAHQEYQHS LHEFKDWLDQ QQERLSCYTQ
3510 3520 3530 3540 3550
LEGDTETLED TLRKLQELQV HCTEGQALLN TLLVSREQVI PWGVPQLEDR
3560 3570 3580 3590 3600
CLEGVQQEWS SYQSRLTDTR SQLNSALAKL RQIEQKFQRL DNWLKGMESK
3610 3620 3630 3640 3650
GQLRTGRRSD RATKEAQLQL LKGWHEEVLV YQEEIEGLSV LAQQVLEETP
3660 3670 3680 3690 3700
ISSRVSTRAT QLTSRYHALL LHLLDTIKQL KEEVSCIEES QSVFCTFSDW
3710 3720 3730 3740 3750
LSTAQKNFSS VTTTNIDVVD RAAMEKKMKK LEALQGDMEL GHTFLKTMRE
3760 3770 3780 3790 3800
KTDRAMMFLE EPEAEQLKEE VDSRLSQLET LIRALRSEIS ATEKSIQLSK
3810 3820 3830 3840 3850
DFLDKYKTQT QWLSETKSLL ASPVEPKAEL YQKKAQLAKY KTIQQTIQSH
3860 3870 3880 3890 3900
ESAVKSVIEK GDALLETIRD PSISENIGKL KTDYQDLCAD AKVHVQSLTE
3910 3920 3930 3940 3950
SVREHEDYNS ELQEVEKWLL QMSGRLVTSD SMQSGNLEMA TQQLARHKAI
3960 3970 3980 3990 4000
MEEIAGFEER LSSLKDKGDH LVSSCTEQVQ AKISQQIQAH QQGTRDSYSA
4010 4020 4030 4040 4050
ICSTAQRVYQ SLDRELQKHV SHQDTLQQCQ TWLSSVKEEI QMQPQTPYGL
4060 4070 4080 4090 4100
QEALKQVKHF RALQEQASTY LDLVCSVCDL SDESVRATAA KIQQTKTMIE
4110 4120 4130 4140 4150
ERMSTSQELS DSWREIKEQK QELSTLFQDM EQQLQSLSRR PAELETKIAQ
4160 4170 4180 4190 4200
NMLDQAREFG QQLQNRQSTL TKMTELVSKL TEGKESPEHT EIGRLSHAWL
4210 4220 4230 4240 4250
ELCHQANKLQ TQREEDLQRT KEYHDCISAM EALFEQVSKE WDNLARTDAE
4260 4270 4280 4290 4300
SSSDHLEALR KLSVVLKDKK STLEDLKEQK QKVMYHLNLD DKELVKEQIG
4310 4320 4330 4340 4350
HFEQRWAHLE SLIERKIQDS ILTLEDMGQV EACLREAREW AEEQQPTLSE
4360 4370 4380 4390 4400
AMKMSPPPEL AQSFLFDHLS ICSELEAKQL LLAQAMGDAD RVLAHLGLNE
4410 4420 4430 4440 4450
RQRLQQLISE TQAEVECLSV KVAQRRKHLS KAFTERTQFL LAVNQAITWV
4460 4470 4480 4490 4500
QQNEKKAQAE EYIALLPDDL SKQVRTCRNI QSSLRAYQSE LTSLWSQGRD
4510 4520 4530 4540 4550
LMKDASEEEK TEMLHKLQEL QSIFEVALQK CSQRLQDLEK VLVTRKYFKA
4560 4570 4580 4590 4600
DLEKICQWLK QADIVTFPEI NLMNGDAELC SQLTKYQQIL DQAMEFENLL
4610 4620 4630 4640 4650
LTVQRTGQEI LPTLNEVDHC YLDEKLIALP QQYNNILGLA KEKQEKIQQA
4660 4670 4680 4690 4700
ILARQEYASF IDVTHKALKE LEEQFHSLGT QPIGLKTEEV VSLQADYKAL
4710 4720 4730 4740 4750
LEELTNLGQA VGELNQKKEG FRSTGQPWMP EEMTQLVSLY NGLKRLIEQR
4760 4770 4780 4790 4800
VEHLDDTLES FEDHQAMAMQ VDSELKATKE QLVKVNAETQ SAEERLKNYH
4810 4820 4830 4840 4850
ALAASLQGAS SHLTRLMEQM DNLVSHMDTA AHEVSKQRVT SWQEELRSLQ
4860 4870 4880 4890 4900
SSVGELIVEC ENRFVQSKDF ETEVNRTLTW LQQIKDELGS EVVVDVKVEK
4910 4920 4930 4940 4950
VQEEIRKQQI MQEEVQSRLR IVAALSTREK QKYTSANELV PAHVDSSLQE
4960 4970 4980 4990 5000
MAKLEADVQR ALSSKQITLE QALVLCQKYH SRMQAACEWL EDAVGFLQQA
5010 5020 5030 5040 5050
SLGVDVENYE ECLRQQEDIM ATEQEFLGVL EELESLPPQL ENLVNPTAKE
5060 5070 5080 5090 5100
QLRLSVESAQ QRGVEVRDQL QCHQDVLNSC VAQWNSYQEA RQTVIDLMNE
5110 5120 5130 5140 5150
VEKKLTEFST AKAATNQEAE EKLRSHKSLV SMVNSFQEKL TGLEEQASQL
5160 5170 5180 5190 5200
EQIGSDASKA TISRSMTTVW QRWTRLRSVA RGQERVLEDT AHEWRTFREK
5210 5220 5230 5240 5250
MMKVRSLTEE VKGRVPDCTA EKASKATLQS HLDQYELVSQ DLERELSSLT
5260 5270 5280 5290 5300
LLRQYALSLL HDVEVSVPTA DHEQLPSLKE IKAVQDQLES LLQKARAGKS
5310 5320 5330 5340 5350
RVQQELSDRE GVERGLSLVK SWIQDSRELL LNPTSDLDIL SQELEVMHGE
5360 5370 5380 5390 5400
LITHRQNVDK LAEQQQSKYL DLYTILPSEI SMQLAEVSLA LGSIEDQVQA
5410 5420 5430 5440 5450
RERDIQKSRV IKEEFNSRIH DVSEKMKAVS TALKEKATDI DQAKDEARRL
5460 5470 5480 5490 5500
CDELDCCGRT LAELEAAVQD FGRRNPLIAR QLADAIAKLR EIHHHTLRLA
5510 5520 5530 5540 5550
DYKTIWLKKA DAHLDEYNEM FEFIVKWTDR ARSLVKANII WNSSSHLQEQ
5560 5570 5580 5590 5600
IRMYQAVLRE SRELHGDLDS MQEKVEILSE TLQVEAMGQQ VSELSRHTEE
5610 5620 5630 5640 5650
LEQSIRSRLQ SLQDAAKDME KFESEVKVLH VSLDQVQATL TSPELARLSL
5660 5670 5680 5690 5700
KEQLAQRQRL LADMESFKQQ VEAVQECQSA LRVPEEVVTS LSICRTALNL
5710 5720 5730 5740 5750
QQEASQLQHT AIQQCNILQE AVVQYEQYEQ EVKNLQVMIE DAHRVIQDQP
5760 5770 5780 5790 5800
VNTSNIQELQ AQINHHEELA QKIKGYQEQI ASLNSKCKML TVKAKHATTL
5810 5820 5830 5840 5850
LTVSEAEGLT ESLEELDGEL IKRKSQAQVS MSMGRSSLTR APVQELYNPA
5860 5870 5880 5890 5900
LESVASLDDL QRSWETLKNV ISEKQKTLYE ALEKQQRYQG SLQSISSKME
5910 5920 5930 5940 5950
SIETRLNEPP MHDLSPDRQM ILHQNQMEEI IRLQDDIHEL QSSFTEELYN
5960 5970 5980 5990 6000
PDSVDSDSAD QLAMQSSLTV LAERMATIHM KASGKRQILE ERQSERVEKQ
6010 6020 6030 6040 6050
QQAQALQHYL NQADQLDQWL KSTHGYITSC SQDSDAEEQL TDCQNMLLEM
6060 6070 6080 6090 6100
EEKVLALSEL SRHSESLLLE GRPENREDAE QLARKLRTLK GSLLELQRML
6110 6120 6130 6140 6150
QDKQINLQDS LQEASDSSES DSTLSQSPNM QDWLAQARTT RSLQHQDTLQ
6160 6170 6180 6190 6200
KQKELEEQLA EQKKLLKSVA SRGEEILTQQ ASPVRASATE TLSPDVELEG
6210 6220 6230 6240 6250
DSEAVKKQRR KRWESLKKDM TTKLQLLMNT LEQDSKQPFY SRTACVKTAA
6260 6270 6280 6290 6300
PVYKRETHVQ DKSNLMSLHN GFSQTIQEMT PQATEREVIL MEQQLYSAVT
6310 6320 6330 6340 6350
ATSSWVDDVE NTLFSGPALL TENADTQLSN HETLGKEVTE VTQEVGHTQG
6360 6370 6380 6390 6400
LIKGSVGLSE DEQSLMKDTL DCLTRRLGAL DSALDRRCDS MRSRMRELSA
6410 6420 6430 6440 6450
FQTELQRLFT ALSESKFQII QKMAGVLDHT TTKQIETIAE AEETLKDFEH
6460 6470 6480 6490 6500
RITELKARGA ELQPDQFSTN ELLKLQDAYE ELVMTVGSRR SGLNQNMALK
6510 6520 6530 6540 6550
NQYERVLQDL IDLVDTAQDK MTADQKMIAA SVEDVHNLLD KHKEFFQGLE
6560 6570 6580 6590 6600
WHMVLTETFY KKSSAFVLPR ERQTLEETLA RAQDVLKQAH KKGVELECVS
6610 6620 6630 6640 6650
ETWSRLVLDY QTLYRLLEVV EGSLPSVGLV EETEERLNER IQLYQALRSS
6660 6670 6680 6690 6700
LTEHQHKLHQ VLEEGKHLLS YVSCSSLENQ LTVLGEHWLN NTTKVNKELQ
6710 6720 6730 6740 6750
NLQSMLKHLT RYKSESGELS RWLLEALERL EFWNTQFVAG PQELETVKGQ
6760 6770 6780 6790 6800
LSAFLEFSKE VEARSNLKAS VLNEGNQLLR LKKMDTASLR AELACLDSQW
6810 6820 6830 6840 6850
SELLSRIPIV QEKLHQSQMD KLASRHAITE LVNWISLMER VIEEDEENLK
6860 6870 6880 6890 6900
GAVGSKVIQE YLQRYKGFRV DVNCKQLTVD FVNQSVLQIS GADVESKRSD
6910 6920 6930 6940 6950
KTDFAEKLGA MNCHWQILQT RITERVQYLE GLLTSWVEYE GKVQGLQAWL
6960 6970 6980 6990 7000
DAQEERLKRK HRIENLSSVQ NALKDCQEME VMVKEKEREL ERVEEQACAL
7010 7020 7030 7040 7050
VQNKTDEACA VVMESLRALN NTWANLDHLI GQLKISLKSV QDKWNQYKQA
7060 7070 7080 7090 7100
SEEINGYLTE GRYSVSRYRL LTGSLEASRL QVESLQNLQE ELEKQESSMR
7110 7120 7130 7140 7150
KFGSVTLQLL EECHPSVSDT LNNTLKDINA RWSSLQEEIV ERLKSSKALL
7160 7170 7180 7190 7200
QLWQSYKDLY GQSDSSVQTL EEKANQMLKT ASHKDITEEE VSAWIQDCAE
7210 7220 7230 7240 7250
LLRSQAPVQA SLQVLMELGE QLKQQVDTSA VASIQSDHLS LTQRLSVVEQ
7260 7270 7280 7290 7300
SLSRQQVALQ AGVRDYETFN EQLDSLSRWI VEAEEVLKGQ DPNGSSDQSL
7310 7320 7330 7340 7350
IQDRMEDLKK QMLKFSSMAP DLERLNELGY RLPLNDSEIK RMQNLNRSWS
7360 7370 7380 7390 7400
TTSAQTTERF CKLQALLLQQ QTFLEKCETW MEFLVQTEEK LAVEISGNFQ
7410 7420 7430 7440 7450
SLMEQQRAHE LFQAEMFSRQ QILHSIISDG QHMLEQGQVD DRDEFKLKLA
7460 7470 7480 7490 7500
LLSNQWQGVV RRAQQRRGII DSLLRQWQRY REMVEKLRKW LLEVNHQTQS
7510 7520 7530 7540 7550
LQAGTPVPLQ QARAMLDAVQ LREKVLLRQQ GSYILTVEAG RQLLLSADSR
7560 7570 7580 7590 7600
AEAVLQEELL NIQERWRNAN IRLDEQKKEL AVLLRDWERC EKGIGGSLEK
7610 7620 7630 7640 7650
LRAFKRQLSQ PLPDRHEELQ AEQMRCKDLD SMFDGWKEDL THLTVLRESL
7660 7670 7680 7690 7700
SSYISLDDLR VLQERIELLH RQWEEICHQL SLRRQQVSEK MNEWAIFNNK
7710 7720 7730 7740 7750
YKELCEWLTQ MESKVSHNGD VSIEEMIEKL RKDYQEEVSA AQENKLELQH
7760 7770 7780 7790 7800
LGERLARASH ETKASDIEHK LSKVNERWQH LLDLIGARVK KLRETLVAVQ
7810 7820 7830 7840 7850
QLDKNMNSLR SWLAHIETEL SRPIVYDTCD YQEIQRKLDL QQELQRDIEK
7860 7870 7880 7890 7900
HSTGVASVLN LCEVLLHDCD ACATDAECDS IQQATRSLDR RWRSICAMSM
7910 7920 7930 7940 7950
ERRIRIEETW RLWQKFLDDY SHFEEWLMLS EKTAALPNSS GVLYTIAKEE
7960 7970 7980 7990 8000
LKKFETFQRH VHESLTQLEL INKQYQRLAR ENRTDAACSL REMAHNANQR
8010 8020 8030 8040 8050
WDNLQRRVSS VLRRLKHFIS QREEFETARD CILVWLTEMD LQLTNIEHFS
8060 8070 8080 8090 8100
ECDVQAKIKQ LRAFQQEITL NTGKIDHIFL QGEALLEKSE PIDAAVIEEE
8110 8120 8130 8140 8150
LEELQRYCQE VFGRVERYYK KLIRLPLTDD EHDVSFSDRE FDLDEAADVS
8160 8170 8180 8190 8200
SFPWSERLGD GFLSPLPSSS RSAPLRAERS GRDTPASVDS IPLEWDHDYD
8210 8220 8230 8240 8250
LSRGLESASR ALSSSETGDQ AEDDGYLQGS ASALSGDAGS LETHIRQLDK
8260 8270 8280 8290 8300
ALNTSCFHLQ QTENIIRSRT PTGPELDATY MGYMRLLEEC RGSIDAVKRV
8310 8320 8330 8340 8350
GFELKDEDDK ISGFVNPNSS ESQTSGVIER WELLQAQALS KEMRMKQNMQ
8360 8370 8380 8390 8400
QWQQFNSDLS SICSWLDQTE EELQQERGLD LGTDIQTIEL RIKKLKELQK
8410 8420 8430 8440 8450
ALDKRKAIVL SINLCSAEFV QSDSEEAREL QRRLKEMNNR WEKLSSSLDE
8460 8470 8480 8490 8500
WRTALQHALM QCQDFHEMSH GLLLWLENID RRRNEIVPID HTQDSDTLQE
8510 8520 8530 8540 8550
HHKTLLQIRR ELLDTQVKVA SLQDMSLQLL VHSEGSDCLE AKEKVHVIGN
8560 8570 8580 8590 8600
RLKLLLKGVT RDIRELQKTL DISSSQQDLS SWSSADDLDT SGSLSPVSGR
8610 8620 8630 8640 8650
STPSRQRPPR GKSSVSEPGA CVSSLLHSRS LNAAGSAFSH SEDEERPSWC
8660 8670 8680 8690 8700
RSFLKRVFWA ALPLQIILLL VLIVACLVPT SEDGYSCAQL NNFARSFHPM
8710
LSYTNGPPPI
Length:8,710
Mass (Da):1,000,094
Last modified:June 20, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69D2AA7C9C90D92E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W2N1F8W2N1_DANRE
Spectrin repeat-containing, nuclear...
syne1b
113Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX511113 Genomic DNA No translation available.
BX927406 Genomic DNA No translation available.
BX936315 Genomic DNA No translation available.
CR407704 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000091828; ENSDARP00000086261; ENSDARG00000063068
ENSDART00000148520; ENSDARP00000124184; ENSDARG00000063068

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX511113 Genomic DNA No translation available.
BX927406 Genomic DNA No translation available.
BX936315 Genomic DNA No translation available.
CR407704 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000086261

Proteomic databases

PeptideAtlasiE7EZ30

Genome annotation databases

EnsembliENSDART00000091828; ENSDARP00000086261; ENSDARG00000063068
ENSDART00000148520; ENSDARP00000124184; ENSDARG00000063068

Organism-specific databases

ZFINiZDB-GENE-071218-4 syne1b

Phylogenomic databases

eggNOGiKOG0516 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000154481
InParanoidiE7EZ30
TreeFamiTF329280

Gene expression databases

BgeeiENSDARG00000063068 Expressed in 22 organ(s), highest expression level in brain
ExpressionAtlasiE7EZ30 baseline and differential

Family and domain databases

CDDicd00014 CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR012315 KASH
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF10541 KASH, 1 hit
PF00435 Spectrin, 12 hits
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM01249 KASH, 1 hit
SM00150 SPEC, 49 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS51049 KASH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7EZ30_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7EZ30
Secondary accession number(s): F8W4H6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: June 20, 2018
Last modified: November 13, 2019
This is version 74 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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