Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 57 (11 Dec 2019)
Sequence version 2 (20 Jan 2016)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

NHS-like 1b

Gene

nhsl1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NHS-like 1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nhsl1bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040910-1 nhsl1b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7EXR7

PeptideAtlas

More...
PeptideAtlasi
E7EXR7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000042627 Expressed in 22 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7EXR7 baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni171 – 245DisorderedSequence analysisAdd BLAST75
Regioni471 – 490DisorderedSequence analysisAdd BLAST20
Regioni551 – 585DisorderedSequence analysisAdd BLAST35
Regioni692 – 741DisorderedSequence analysisAdd BLAST50
Regioni761 – 785DisorderedSequence analysisAdd BLAST25
Regioni840 – 1101DisorderedSequence analysisAdd BLAST262
Regioni1132 – 1216DisorderedSequence analysisAdd BLAST85
Regioni1275 – 1554DisorderedSequence analysisAdd BLAST280
Regioni1576 – 1606DisorderedSequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili146 – 166Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi171 – 186PolarSequence analysisAdd BLAST16
Compositional biasi194 – 215PolyampholyteSequence analysisAdd BLAST22
Compositional biasi726 – 741PolarSequence analysisAdd BLAST16
Compositional biasi761 – 777PolarSequence analysisAdd BLAST17
Compositional biasi842 – 922PolarSequence analysisAdd BLAST81
Compositional biasi945 – 969PolarSequence analysisAdd BLAST25
Compositional biasi970 – 1022Pro-richSequence analysisAdd BLAST53
Compositional biasi1034 – 1048Pro-richSequence analysisAdd BLAST15
Compositional biasi1057 – 1075Pro-richSequence analysisAdd BLAST19
Compositional biasi1076 – 1094PolarSequence analysisAdd BLAST19
Compositional biasi1142 – 1156PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1157 – 1211PolarSequence analysisAdd BLAST55
Compositional biasi1306 – 1327PolarSequence analysisAdd BLAST22
Compositional biasi1364 – 1381PolarSequence analysisAdd BLAST18
Compositional biasi1394 – 1418PolyampholyteSequence analysisAdd BLAST25
Compositional biasi1428 – 1461PolarSequence analysisAdd BLAST34
Compositional biasi1470 – 1485PolarSequence analysisAdd BLAST16
Compositional biasi1491 – 1513PolarSequence analysisAdd BLAST23
Compositional biasi1581 – 1606PolarSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJSF Eukaryota
ENOG410XXZ7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182963

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E7EXR7

Database of Orthologous Groups

More...
OrthoDBi
60972at2759

TreeFam database of animal gene trees

More...
TreeFami
TF333323

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024845 NHS_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15273 NHS, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

E7EXR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFPERAVEP QLLCRLRGSD GPEKSFITPD GRKVRKPVLF SSLEEVCCHT
60 70 80 90 100
FTSILHQLSD LSRHASDIFL GIETQAGLIS HRTSRIQARL ERIQHTVQTL
110 120 130 140 150
DPKSVKIPVS NLDEEKKWTV HYTAPWHQQE NVFLPGSRPA CVEDLHRQAK
160 170 180 190 200
VNLKTALREC DKLRKDGFRS SQYYSQGPTF SGSSSSQHED EDLEGDDADK
210 220 230 240 250
KSTASSGEEE KDSCQMRAQS PAQVEGVEVD GQMSSSKASV LPTPEEKMRQ
260 270 280 290 300
QAQAVLTDIV PINVTGETFD RQASIRRSLI NTDTLVRRPK KVKRRKTISG
310 320 330 340 350
VPDSVQQELA AKGRGGELRP QSMFIPGQYS TLGRVMNGNS TLRQSVTKDS
360 370 380 390 400
GCQTEAVKIV PPSVRRIRAQ KGQGIAAQMA GISTSATNIS SVSDGSSTGG
410 420 430 440 450
SIVAMAPQFG NDIQRFHSLP RGARVSLNAE PIYSSTPFRK EDSCAKAPKQ
460 470 480 490 500
IGKLQVDNTA VHMRNAPRVC TQARPKSQEV RGSQREWGSV SGPACVVSPH
510 520 530 540 550
AAYSTSLIPN ATLSCSAEVF ALHSKSSPGQ SPLSGSPYTK ARPLSMVSVV
560 570 580 590 600
NSGSTSSVGT GSHTPDAGMK DTCSETGQSD SSLHSHSTIA AGTLSSDEQW
610 620 630 640 650
IYDTPDNALP RRTMTSSCST PINHLYSSLE RSSKGTDSSS LYSMDNDGYY
660 670 680 690 700
TSMHLDSGLR SRSHGSGHGH GIGGRAVRHS MYECLGEQED RNSLCSDHSL
710 720 730 740 750
SRSISLRKPK KPPLPPARTD SLRRKPGKNS SPSANIGQSN IRNGSLLNES
760 770 780 790 800
LIATLQQSLQ NGLKGKGSST SPSHSPCSDY EDPWMLRPRS QSSISASSSG
810 820 830 840 850
VSATGMAHVY SICPVTPSHS DTSSLRSDYA DSWGYYMEYP RPSGDQTQSP
860 870 880 890 900
CTNSHSAGQV SEMANGRGPL NGNQANLPAV QEGSDMSAKP RTGTSSPDRV
910 920 930 940 950
HRLTSPSSGY SSQSNTPTAG TPVPSFMRCM SPSGKPKPRV PERKSSLLSS
960 970 980 990 1000
VSISSSSTSL SSNTSDSNRS NIPPPPPLPA APVVLVPLNP PSFPPPLPPP
1010 1020 1030 1040 1050
SPVCTEDQKF PPPPPPLPTT PHQQASMNPL QNNSSPEFPP PPPPEVLTDP
1060 1070 1080 1090 1100
ACSGFNSSFS PPPPPPPPPL PTYSPSQNQH LPHMTPQTPS SASLKEIKGC
1110 1120 1130 1140 1150
LKPVNLEGRP VLPQSEEPNK VSMPLITPFA LQSVQLRPAK RPENNEVSRT
1160 1170 1180 1190 1200
DRPQTPEKTH PTVPQISCIS PNVSLSSTEE KPSIQHSQDG LVEAQTDYSV
1210 1220 1230 1240 1250
KSNSDPTSFL TNGPIDLGEA TDEVDGLKTF LSTQVEKSLN STPKKKPPMI
1260 1270 1280 1290 1300
SKKPKFSLTF SSVDHVRDFV SAEVLDPIPV LEKEEETTEK SSFDISVPPV
1310 1320 1330 1340 1350
EIRDISPTNG ESQEFSQSSG TTILDVDKST SEAEDEEERD DEDVTSSTGS
1360 1370 1380 1390 1400
FSSKDDENGD VFESSTLDVA QSPSINGDSC GDMVTPTRPR TTEDLFAAIH
1410 1420 1430 1440 1450
RSKRKVLGRK ESEEDRSRGP LSPPVTPTAQ SPSLTSSLPR QSGSIQRSLR
1460 1470 1480 1490 1500
KSATSSDTFK ALLLKKGSRS ESSFRMSATE MLRSTDPRFQ RTRSLDSSFD
1510 1520 1530 1540 1550
PASPTSESPC SSPGRSKRVA DDWARNDGMF STSPSLIGPK YGRSRTPPSA
1560 1570 1580 1590 1600
ASSKYNARCR ILSSPMTVIC ERDGELTDCE DPVSPSNTPL PISQDSNSTL

CEQSSS
Length:1,606
Mass (Da):173,039
Last modified:January 20, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i646069B32532DD5A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1R6W8F1R6W8_DANRE
NHS-like 1b
nhsl1b
1,527Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL929182 Genomic DNA No translation available.
BX510322 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005160821.1, XM_005160764.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000062532; ENSDARP00000062531; ENSDARG00000042627

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
447799

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929182 Genomic DNA No translation available.
BX510322 Genomic DNA No translation available.
RefSeqiXP_005160821.1, XM_005160764.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiE7EXR7
PeptideAtlasiE7EXR7

Genome annotation databases

EnsembliENSDART00000062532; ENSDARP00000062531; ENSDARG00000042627
GeneIDi447799

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
447799
ZFINiZDB-GENE-040910-1 nhsl1b

Phylogenomic databases

eggNOGiENOG410IJSF Eukaryota
ENOG410XXZ7 LUCA
GeneTreeiENSGT00950000182963
InParanoidiE7EXR7
OrthoDBi60972at2759
TreeFamiTF333323

Gene expression databases

BgeeiENSDARG00000042627 Expressed in 22 organ(s), highest expression level in embryo
ExpressionAtlasiE7EXR7 baseline

Family and domain databases

InterProiView protein in InterPro
IPR024845 NHS_fam
PfamiView protein in Pfam
PF15273 NHS, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7EXR7_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7EXR7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: January 20, 2016
Last modified: December 11, 2019
This is version 57 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again