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UniProtKB - E7EXJ6 (E7EXJ6_DANRE)

Entry version 73 (29 Sep 2021)
Sequence version 1 (08 Mar 2011)
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Protein
Submitted name:

Nucleoporin 188

Gene

nup188

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, TranslocationARBA annotation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-159227, Transport of the SLBP independent Mature mRNA
R-DRE-159230, Transport of the SLBP Dependant Mature mRNA
R-DRE-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DRE-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DRE-191859, snRNP Assembly
R-DRE-3108214, SUMOylation of DNA damage response and repair proteins
R-DRE-3232142, SUMOylation of ubiquitinylation proteins
R-DRE-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DRE-3371453, Regulation of HSF1-mediated heat shock response
R-DRE-4085377, SUMOylation of SUMOylation proteins
R-DRE-4551638, SUMOylation of chromatin organization proteins
R-DRE-4570464, SUMOylation of RNA binding proteins
R-DRE-4615885, SUMOylation of DNA replication proteins
R-DRE-5578749, Transcriptional regulation by small RNAs
R-DRE-9615933, Postmitotic nuclear pore complex (NPC) reformation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nucleoporin 188Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nup188Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-030131-7184, nup188

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		E7EXJ6

PeptideAtlas

More...PeptideAtlasi		E7EXJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSDARG00000030022, Expressed in female gonad and 32 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000043430

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 942Nup188InterPro annotationAdd BLAST914

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1690 – 1714DisorderedSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4833, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005742

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002623_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		E7EXJ6

Identification of Orthologs from Complete Genome Data

More...OMAi		GEHWVSV

Database of Orthologous Groups

More...OrthoDBi		79804at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		E7EXJ6

TreeFam database of animal gene trees

More...TreeFami		TF101106

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR018864, Nucleoporin_Nup188_N
IPR044840, Nup188

The PANTHER Classification System

More...PANTHERi		PTHR31431, PTHR31431, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10487, Nup188, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7EXJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSEMCVRS SRELWSILLG RSALREPAQI EDELNRNWER LLQGLSFYKQ 
        60         70         80         90        100
PSTSAADKLK ADKDTPQALK DFGLRISKLL GLDEQQSVQV LQCYLQEDYR 
       110        120        130        140        150
GTRNTLKAVL QDERQSQALL LKIADYYYEE RLCVLRCVLH LLTYFQDERH 
       160        170        180        190        200
PYRAEYSNCV SKLEKDLVSN YRQQFETLSK SEAPTWETHG NLMTERQVSR 
       210        220        230        240        250
WFVQCLKEQA LLLEILFLYY AYFEMSPNDL CTFTRLFKEQ GFGQRQTNRH 
       260        270        280        290        300
LVDKSMDTLV ERIGYFSSLM LVEGMDIDFL HKCALEDRTE QHQFYDQQDV 
       310        320        330        340        350
CKEMDQMLLT FGDIPHHGPV LLAWVLLRHT LRPEEVSSVI RRLGNTTLQL 
       360        370        380        390        400
GVFQYLTNML QALGSAGNNC TVSTARMCIY GLLSFVITSF EEDTLGSQQH 
       410        420        430        440        450
LINAACEVLG APSLAELFWE SKPNMGLGVI LDSAVGVFPY KTGPLLQLLT 
       460        470        480        490        500
ALLSDKSTAK KVYTFLDKMS FYTEAYKHRP NDVISREDGT LWRRQTHKLL 
       510        520        530        540        550
YPLGVGQTNL RMPQGCFGQV CEGKQLSVGE QGFLVRWEYS YSSWTLFTCE 
       560        570        580        590        600
IEMLLHVVST ADVLVHCQRV KPILDLVHKI ISTDWTVSDC LLPLTSRIYM 
       610        620        630        640        650
LLQRLTSIIN PPVDVITSCV NCLIALAARQ PAKVWSSLHH TGFLPFASTP 
       660        670        680        690        700
LTNMTQAISA EGMKAGNYGN LLVLIEQPRG EYSVTIAFLR LVTTLVKGQL 
       710        720        730        740        750
GSTQSRGLIP CVLLVLKEML PTYHKWRYNT YGVRERIGCL ILELVHAILN 
       760        770        780        790        800
LNQECESEGS APSLQSLCIY SLANTEAGQA VVNIMGVGVD TINMVLAAQP 
       810        820        830        840        850
SSGGSEGPGQ VLIQTVKLAF SVTNNVIRLK PQSDTASPLE QALTQHGGHG 
       860        870        880        890        900
NNLIAVLAKY IYHKHDPALP RLAIQLLKRL ATVAPMSVYA CLGSDAAAIR 
       910        920        930        940        950
DAFLTRLQSR TEDMRIKVTI LEFLTVAVET QPGLIELFLN LETKDASDGA 
       960        970        980        990       1000
KEFSLGEWSC LSVVLELLDS KQQGKYWCPP LLQRAALAFL HALWQDRRDS 
      1010       1020       1030       1040       1050
ALSVLRTKEK FWENLTTPLF GNLPPPSETT EPCVLESCAF VMKIIALEIY 
      1060       1070       1080       1090       1100
YVVSGVLEPS LKAALESFSS KRRYEFWSDY VRELVCVACD GEEEGLRSLS 
      1110       1120       1130       1140       1150
ESQMLISAWR TLLILSTSHS EVMHLKDDTV RQKLFMDVLE GTKAALLMSQ 
      1160       1170       1180       1190       1200
SVFCLRLGSM MVTLLLILLK QWKSVLVSAP ALLPPLSLML ESVLHAEQQL 
      1210       1220       1230       1240       1250
MDRTKAKLLS GLILALQIQG LNGGEISQLP QLLLCVCEMV QDEALALIDS 
      1260       1270       1280       1290       1300
TRHMIQRGDV QEDSMETDSP HVQKDQQDSV CVLALHLSKE LCRADEDGEQ 
      1310       1320       1330       1340       1350
WLQVVRKLPV LPSVLSALEL SLRSKQNLYF TEAALHLLLT LARTPQGAAA 
      1360       1370       1380       1390       1400
VAGAGVIQSI CLPLLSVYEG PANGANQAFV RKCQDAPSWP GVYRLSLSLM 
      1410       1420       1430       1440       1450
ESLLKTLRYN FINEALDFVG VHQERILQCL NAVRTVQSLA CLDEADHTVG 
      1460       1470       1480       1490       1500
FLLQLSNFCK EWQFHLPQLL RDVQVNLCYL CQTCTYLLHS KKMLHHYLQA 
      1510       1520       1530       1540       1550
KNGEGLPQGP HPQRALQPAS KELLEGEREE AESKALQAVQ CSLLKILSKT 
      1560       1570       1580       1590       1600
LATLQHFTPD CCQILLDQAM DLAEYRTLFV LSFSTPAFDS DVAPSFGTLM 
      1610       1620       1630       1640       1650
ATINVALSML GEIEKKKEPL ISSEDTQALK SLLMFSMENC FYVLVSQAVR 
      1660       1670       1680       1690       1700
CLKDPAVSHR DKQRLKQELS SELSTLLSTL FRFFRRGSPS SPASGLLPSP 
      1710       1720       1730 
QTKPPTPGSK VTPEGQEPFI QLVQAFVRQV QR
Length:1,732
Mass (Da):194,208
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25D1ABE363DEDCA2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX469935 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_001923018.1, XM_001922983.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSDART00000043431; ENSDARP00000043430; ENSDARG00000030022

Database of genes from NCBI RefSeq genomes

More...GeneIDi		559225

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:559225

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX469935 Genomic DNA No translation available.
RefSeqiXP_001923018.1, XM_001922983.5

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043430

Proteomic databases

PaxDbiE7EXJ6
PeptideAtlasiE7EXJ6

Genome annotation databases

EnsembliENSDART00000043431; ENSDARP00000043430; ENSDARG00000030022
GeneIDi559225
KEGGidre:559225

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23511
ZFINiZDB-GENE-030131-7184, nup188

Phylogenomic databases

eggNOGiKOG4833, Eukaryota
GeneTreeiENSGT00390000005742
HOGENOMiCLU_002623_1_0_1
InParanoidiE7EXJ6
OMAiGEHWVSV
OrthoDBi79804at2759
PhylomeDBiE7EXJ6
TreeFamiTF101106

Enzyme and pathway databases

ReactomeiR-DRE-159227, Transport of the SLBP independent Mature mRNA
R-DRE-159230, Transport of the SLBP Dependant Mature mRNA
R-DRE-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DRE-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DRE-191859, snRNP Assembly
R-DRE-3108214, SUMOylation of DNA damage response and repair proteins
R-DRE-3232142, SUMOylation of ubiquitinylation proteins
R-DRE-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DRE-3371453, Regulation of HSF1-mediated heat shock response
R-DRE-4085377, SUMOylation of SUMOylation proteins
R-DRE-4551638, SUMOylation of chromatin organization proteins
R-DRE-4570464, SUMOylation of RNA binding proteins
R-DRE-4615885, SUMOylation of DNA replication proteins
R-DRE-5578749, Transcriptional regulation by small RNAs
R-DRE-9615933, Postmitotic nuclear pore complex (NPC) reformation

Gene expression databases

BgeeiENSDARG00000030022, Expressed in female gonad and 32 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR018864, Nucleoporin_Nup188_N
IPR044840, Nup188
PANTHERiPTHR31431, PTHR31431, 1 hit
PfamiView protein in Pfam
PF10487, Nup188, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7EXJ6_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7EXJ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 29, 2021
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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