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Entry version 73 (29 Sep 2021)
Sequence version 1 (08 Mar 2011)
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Protein
Submitted name:

Nucleoporin 188

Gene

nup188

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, TranslocationARBA annotation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-159227, Transport of the SLBP independent Mature mRNA
R-DRE-159230, Transport of the SLBP Dependant Mature mRNA
R-DRE-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DRE-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DRE-191859, snRNP Assembly
R-DRE-3108214, SUMOylation of DNA damage response and repair proteins
R-DRE-3232142, SUMOylation of ubiquitinylation proteins
R-DRE-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DRE-3371453, Regulation of HSF1-mediated heat shock response
R-DRE-4085377, SUMOylation of SUMOylation proteins
R-DRE-4551638, SUMOylation of chromatin organization proteins
R-DRE-4570464, SUMOylation of RNA binding proteins
R-DRE-4615885, SUMOylation of DNA replication proteins
R-DRE-5578749, Transcriptional regulation by small RNAs
R-DRE-9615933, Postmitotic nuclear pore complex (NPC) reformation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nucleoporin 188Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nup188Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-030131-7184, nup188

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7EXJ6

PeptideAtlas

More...
PeptideAtlasi
E7EXJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000030022, Expressed in female gonad and 32 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000043430

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 942Nup188InterPro annotationAdd BLAST914

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1690 – 1714DisorderedSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4833, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005742

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002623_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E7EXJ6

Identification of Orthologs from Complete Genome Data

More...
OMAi
GEHWVSV

Database of Orthologous Groups

More...
OrthoDBi
79804at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E7EXJ6

TreeFam database of animal gene trees

More...
TreeFami
TF101106

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR018864, Nucleoporin_Nup188_N
IPR044840, Nup188

The PANTHER Classification System

More...
PANTHERi
PTHR31431, PTHR31431, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10487, Nup188, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7EXJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSEMCVRS SRELWSILLG RSALREPAQI EDELNRNWER LLQGLSFYKQ
60 70 80 90 100
PSTSAADKLK ADKDTPQALK DFGLRISKLL GLDEQQSVQV LQCYLQEDYR
110 120 130 140 150
GTRNTLKAVL QDERQSQALL LKIADYYYEE RLCVLRCVLH LLTYFQDERH
160 170 180 190 200
PYRAEYSNCV SKLEKDLVSN YRQQFETLSK SEAPTWETHG NLMTERQVSR
210 220 230 240 250
WFVQCLKEQA LLLEILFLYY AYFEMSPNDL CTFTRLFKEQ GFGQRQTNRH
260 270 280 290 300
LVDKSMDTLV ERIGYFSSLM LVEGMDIDFL HKCALEDRTE QHQFYDQQDV
310 320 330 340 350
CKEMDQMLLT FGDIPHHGPV LLAWVLLRHT LRPEEVSSVI RRLGNTTLQL
360 370 380 390 400
GVFQYLTNML QALGSAGNNC TVSTARMCIY GLLSFVITSF EEDTLGSQQH
410 420 430 440 450
LINAACEVLG APSLAELFWE SKPNMGLGVI LDSAVGVFPY KTGPLLQLLT
460 470 480 490 500
ALLSDKSTAK KVYTFLDKMS FYTEAYKHRP NDVISREDGT LWRRQTHKLL
510 520 530 540 550
YPLGVGQTNL RMPQGCFGQV CEGKQLSVGE QGFLVRWEYS YSSWTLFTCE
560 570 580 590 600
IEMLLHVVST ADVLVHCQRV KPILDLVHKI ISTDWTVSDC LLPLTSRIYM
610 620 630 640 650
LLQRLTSIIN PPVDVITSCV NCLIALAARQ PAKVWSSLHH TGFLPFASTP
660 670 680 690 700
LTNMTQAISA EGMKAGNYGN LLVLIEQPRG EYSVTIAFLR LVTTLVKGQL
710 720 730 740 750
GSTQSRGLIP CVLLVLKEML PTYHKWRYNT YGVRERIGCL ILELVHAILN
760 770 780 790 800
LNQECESEGS APSLQSLCIY SLANTEAGQA VVNIMGVGVD TINMVLAAQP
810 820 830 840 850
SSGGSEGPGQ VLIQTVKLAF SVTNNVIRLK PQSDTASPLE QALTQHGGHG
860 870 880 890 900
NNLIAVLAKY IYHKHDPALP RLAIQLLKRL ATVAPMSVYA CLGSDAAAIR
910 920 930 940 950
DAFLTRLQSR TEDMRIKVTI LEFLTVAVET QPGLIELFLN LETKDASDGA
960 970 980 990 1000
KEFSLGEWSC LSVVLELLDS KQQGKYWCPP LLQRAALAFL HALWQDRRDS
1010 1020 1030 1040 1050
ALSVLRTKEK FWENLTTPLF GNLPPPSETT EPCVLESCAF VMKIIALEIY
1060 1070 1080 1090 1100
YVVSGVLEPS LKAALESFSS KRRYEFWSDY VRELVCVACD GEEEGLRSLS
1110 1120 1130 1140 1150
ESQMLISAWR TLLILSTSHS EVMHLKDDTV RQKLFMDVLE GTKAALLMSQ
1160 1170 1180 1190 1200
SVFCLRLGSM MVTLLLILLK QWKSVLVSAP ALLPPLSLML ESVLHAEQQL
1210 1220 1230 1240 1250
MDRTKAKLLS GLILALQIQG LNGGEISQLP QLLLCVCEMV QDEALALIDS
1260 1270 1280 1290 1300
TRHMIQRGDV QEDSMETDSP HVQKDQQDSV CVLALHLSKE LCRADEDGEQ
1310 1320 1330 1340 1350
WLQVVRKLPV LPSVLSALEL SLRSKQNLYF TEAALHLLLT LARTPQGAAA
1360 1370 1380 1390 1400
VAGAGVIQSI CLPLLSVYEG PANGANQAFV RKCQDAPSWP GVYRLSLSLM
1410 1420 1430 1440 1450
ESLLKTLRYN FINEALDFVG VHQERILQCL NAVRTVQSLA CLDEADHTVG
1460 1470 1480 1490 1500
FLLQLSNFCK EWQFHLPQLL RDVQVNLCYL CQTCTYLLHS KKMLHHYLQA
1510 1520 1530 1540 1550
KNGEGLPQGP HPQRALQPAS KELLEGEREE AESKALQAVQ CSLLKILSKT
1560 1570 1580 1590 1600
LATLQHFTPD CCQILLDQAM DLAEYRTLFV LSFSTPAFDS DVAPSFGTLM
1610 1620 1630 1640 1650
ATINVALSML GEIEKKKEPL ISSEDTQALK SLLMFSMENC FYVLVSQAVR
1660 1670 1680 1690 1700
CLKDPAVSHR DKQRLKQELS SELSTLLSTL FRFFRRGSPS SPASGLLPSP
1710 1720 1730
QTKPPTPGSK VTPEGQEPFI QLVQAFVRQV QR
Length:1,732
Mass (Da):194,208
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25D1ABE363DEDCA2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX469935 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_001923018.1, XM_001922983.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000043431; ENSDARP00000043430; ENSDARG00000030022

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
559225

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:559225

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX469935 Genomic DNA No translation available.
RefSeqiXP_001923018.1, XM_001922983.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043430

Proteomic databases

PaxDbiE7EXJ6
PeptideAtlasiE7EXJ6

Genome annotation databases

EnsembliENSDART00000043431; ENSDARP00000043430; ENSDARG00000030022
GeneIDi559225
KEGGidre:559225

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23511
ZFINiZDB-GENE-030131-7184, nup188

Phylogenomic databases

eggNOGiKOG4833, Eukaryota
GeneTreeiENSGT00390000005742
HOGENOMiCLU_002623_1_0_1
InParanoidiE7EXJ6
OMAiGEHWVSV
OrthoDBi79804at2759
PhylomeDBiE7EXJ6
TreeFamiTF101106

Enzyme and pathway databases

ReactomeiR-DRE-159227, Transport of the SLBP independent Mature mRNA
R-DRE-159230, Transport of the SLBP Dependant Mature mRNA
R-DRE-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-DRE-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DRE-191859, snRNP Assembly
R-DRE-3108214, SUMOylation of DNA damage response and repair proteins
R-DRE-3232142, SUMOylation of ubiquitinylation proteins
R-DRE-3301854, Nuclear Pore Complex (NPC) Disassembly
R-DRE-3371453, Regulation of HSF1-mediated heat shock response
R-DRE-4085377, SUMOylation of SUMOylation proteins
R-DRE-4551638, SUMOylation of chromatin organization proteins
R-DRE-4570464, SUMOylation of RNA binding proteins
R-DRE-4615885, SUMOylation of DNA replication proteins
R-DRE-5578749, Transcriptional regulation by small RNAs
R-DRE-9615933, Postmitotic nuclear pore complex (NPC) reformation

Gene expression databases

BgeeiENSDARG00000030022, Expressed in female gonad and 32 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR018864, Nucleoporin_Nup188_N
IPR044840, Nup188
PANTHERiPTHR31431, PTHR31431, 1 hit
PfamiView protein in Pfam
PF10487, Nup188, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7EXJ6_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7EXJ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 29, 2021
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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