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Protein
Submitted name:

Eukaryotic translation initiation factor 4B

Gene

EIF4B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic translation initiation factor 4BImported
Gene namesi
Name:EIF4BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000063046.17
HGNCiHGNC:3285 EIF4B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000063046

PTM / Processingi

Proteomic databases

EPDiE7EX17
MaxQBiE7EX17
PeptideAtlasiE7EX17
PRIDEiE7EX17

Expressioni

Gene expression databases

BgeeiENSG00000063046 Expressed in 240 organ(s), highest expression level in female gonad
ExpressionAtlasiE7EX17 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE7EX17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 173RRMInterPro annotationAdd BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili370 – 397Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
ENOG4111NS2 LUCA
GeneTreeiENSGT00530000063406
OMAiFGNWERK
OrthoDBiEOG091G0DWC

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR033107 EIF-4B
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR23236:SF2 PTHR23236:SF2, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.iShow all

E7EX17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASAKKKNK KGKTISLTDF LAEDGGTGGG STYVSKPVSW ADETDDLEGD
60 70 80 90 100
VSTTWHSNDD DVYRAPPIDR SILPTAPRAA REPNIDRSRL PKSPPYTAFL
110 120 130 140 150
GNLPYDVTEE SIKEFFRGLN ISAVRLPREP SNPERLKGFG YAEFEDLDSL
160 170 180 190 200
LSALSLNEES LGNRRIRVDV ADQAQDKDRD DRSFGRDRNR DSDKTDTDWR
210 220 230 240 250
ARPATDSFDD YPPRRGDDSF GDKYRDRYDS DRYRDGYRDG YRDGPRRDMD
260 270 280 290 300
RYGGRDRYDD RGSRDYDRGY DSRIGSGRRA FGSGYRRDDD YRGGGDRYED
310 320 330 340 350
RYDRRDDRSW SSRDDYSRDD YRRDDRGPPQ RPKLNLKPRS TPKEDDSSAS
360 370 380 390 400
TSQSTRAASI FGGAKPVDTA AREREVEERL QKEQEKLQRQ LDEPKLERRP
410 420 430 440 450
RERHPSWRSE ETQERERSRT GSESSQTGTS TTSSRSKSDQ DARRRESEKS
460 470 480 490 500
LENETLNKEE DCHSPTSKPP KPDQPLKVMP APPPKENAWV KRSSNPPARS
510 520 530 540 550
QSSDTEQQSP TSGGGKVAPA QPSEEGPGRK DENKVDGMNA PKGQTGNSSR
560 570 580 590 600
GPGDGGNRDH WKESDRKDGK KDQDSRSAPE PKKPEENPAS KFSSASKYAA
610
LSVDGEDENE GEDYAE
Length:616
Mass (Da):69,698
Last modified:March 8, 2011 - v1
Checksum:i0F133C6134D04FA4
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P23588IF4B_HUMAN
Eukaryotic translation initiation f...
EIF4B
611Annotation score:
F8VX11F8VX11_HUMAN
Eukaryotic translation initiation f...
EIF4B
360Annotation score:
F8VP89F8VP89_HUMAN
Eukaryotic translation initiation f...
EIF4B
275Annotation score:
F8W0K0F8W0K0_HUMAN
Eukaryotic translation initiation f...
EIF4B
169Annotation score:
F8VYE9F8VYE9_HUMAN
Eukaryotic translation initiation f...
EIF4B
185Annotation score:
F8VSC7F8VSC7_HUMAN
Eukaryotic translation initiation f...
EIF4B
227Annotation score:
F8VRU1F8VRU1_HUMAN
Eukaryotic translation initiation f...
EIF4B
175Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068888 Genomic DNA No translation available.
RefSeqiNP_001287750.1, NM_001300821.2
UniGeneiHs.648394
Hs.702041

Genome annotation databases

EnsembliENST00000420463; ENSP00000388806; ENSG00000063046
GeneIDi1975
UCSCiuc010snu.3 human

Similar proteinsi

Entry informationi

Entry nameiE7EX17_HUMAN
AccessioniPrimary (citable) accession number: E7EX17
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 12, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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