UniProtKB - E7EWX6 (E7EWX6_HUMAN)
Protein
Submitted name:
NAD-dependent protein deacetylase sirtuin-2
Gene
SIRT2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: NAD-dependent protein deacetylase sirtuin-2Imported |
Gene namesi | Name:SIRT2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10886 SIRT2 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
PTM / Processingi
Proteomic databases
jPOSTi | E7EWX6 |
MaxQBi | E7EWX6 |
PeptideAtlasi | E7EWX6 |
PRIDEi | E7EWX6 |
ProteomicsDBi | 18934 |
Expressioni
Gene expression databases
Bgeei | ENSG00000068903 Expressed in 230 organ(s), highest expression level in C1 segment of cervical spinal cord |
ExpressionAtlasi | E7EWX6 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 237 | Deacetylase sirtuin-typeInterPro annotationAdd BLAST | 210 |
Phylogenomic databases
eggNOGi | KOG2682 Eukaryota COG0846 LUCA |
GeneTreei | ENSGT00940000157514 |
Family and domain databases
Gene3Di | 3.30.1600.10, 1 hit |
InterProi | View protein in InterPro IPR029035 DHS-like_NAD/FAD-binding_dom IPR003000 Sirtuin IPR026591 Sirtuin_cat_small_dom_sf IPR026590 Ssirtuin_cat_dom |
Pfami | View protein in Pfam PF02146 SIR2, 1 hit |
SUPFAMi | SSF52467 SSF52467, 1 hit |
PROSITEi | View protein in PROSITE PS50305 SIRTUIN, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
E7EWX6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDFLRNLFSQ TLSLGSQKER LLDELTLEGV ARYMQSERCR RVICLVGAGI
60 70 80 90 100
STSAGIPDFR SPSTGLYDNL EKYHLPYPEA IFEISYFKKH PEPFFALAKE
110 120 130 140 150
LYPGQFKPTI CHYFMRLLKD KGLLLRCYTQ NIDTLERIAG LEQEDLVEAH
160 170 180 190 200
GTFYTSHCVS ASCRHEYPLS WMKEKIFSEV TPKCEDCQSL VKPDIVFFGE
210 220 230
SLPARFFSCM QSDFLKVDLL LVMGTSLQVQ PFASLIS
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8IXJ6 | SIR2_HUMAN | NAD-dependent protein deacetylase s... | SIRT2 SIR2L, SIR2L2 | 389 | Annotation score: | ||
A0A087WYM3 | A0A087WYM3_HUMAN | NAD-dependent protein deacetylase | SIRT2 | 389 | Annotation score: | ||
A0A0A0MRF5 | A0A0A0MRF5_HUMAN | NAD-dependent protein deacetylase s... | SIRT2 | 234 | Annotation score: | ||
B5MCS1 | B5MCS1_HUMAN | NAD-dependent protein deacetylase s... | SIRT2 | 169 | Annotation score: | ||
C9JZQ0 | C9JZQ0_HUMAN | NAD-dependent protein deacetylase s... | SIRT2 | 130 | Annotation score: | ||
F8WCF4 | F8WCF4_HUMAN | NAD-dependent protein deacetylase s... | SIRT2 | 111 | Annotation score: | ||
C9J3U7 | C9J3U7_HUMAN | NAD-dependent protein deacetylase s... | SIRT2 | 78 | Annotation score: | ||
C9JR33 | C9JR33_HUMAN | NAD-dependent protein deacetylase s... | SIRT2 | 73 | Annotation score: | ||
F8WF57 | F8WF57_HUMAN | NAD-dependent protein deacetylase s... | SIRT2 | 39 | Annotation score: | ||
F8WDM4 | F8WDM4_HUMAN | NAD-dependent protein deacetylase s... | SIRT2 | 52 | Annotation score: | ||
There is more potential isoformShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 237 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011455 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000414941; ENSP00000404309; ENSG00000068903 |
UCSCi | uc060ygz.1 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011455 Genomic DNA No translation available. |
3D structure databases
SMRi | E7EWX6 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | E7EWX6, 1 interactor |
Proteomic databases
jPOSTi | E7EWX6 |
MaxQBi | E7EWX6 |
PeptideAtlasi | E7EWX6 |
PRIDEi | E7EWX6 |
ProteomicsDBi | 18934 |
Genome annotation databases
Ensembli | ENST00000414941; ENSP00000404309; ENSG00000068903 |
UCSCi | uc060ygz.1 human |
Organism-specific databases
HGNCi | HGNC:10886 SIRT2 |
OpenTargetsi | ENSG00000068903 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2682 Eukaryota COG0846 LUCA |
GeneTreei | ENSGT00940000157514 |
Miscellaneous databases
ChiTaRSi | SIRT2 human |
Gene expression databases
Bgeei | ENSG00000068903 Expressed in 230 organ(s), highest expression level in C1 segment of cervical spinal cord |
ExpressionAtlasi | E7EWX6 baseline and differential |
Family and domain databases
Gene3Di | 3.30.1600.10, 1 hit |
InterProi | View protein in InterPro IPR029035 DHS-like_NAD/FAD-binding_dom IPR003000 Sirtuin IPR026591 Sirtuin_cat_small_dom_sf IPR026590 Ssirtuin_cat_dom |
Pfami | View protein in Pfam PF02146 SIR2, 1 hit |
SUPFAMi | SSF52467 SSF52467, 1 hit |
PROSITEi | View protein in PROSITE PS50305 SIRTUIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7EWX6_HUMAN | |
Accessioni | E7EWX6Primary (citable) accession number: E7EWX6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | July 31, 2019 | |
This is version 57 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |