ABCB1

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Multidrug resistance protein 1Imported
Gene namesⁱ	Name:ABCB1Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000085563.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:40 ABCB1

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000085563

OpenTargetsⁱ

ENSG00000085563

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	E7EWT8
PeptideAtlas More...PeptideAtlasⁱ	E7EWT8
PRIDEⁱ	E7EWT8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000085563 Expressed in 186 organ(s), highest expression level in right adrenal gland
ExpressionAtlasⁱ	E7EWT8 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	E7EWT8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG0055 Eukaryota COG1132 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062896

Sequence (1+)ⁱ

Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

E7EWT8-1 [UniParc]FASTA Add to basket

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        10         20         30         40 
MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDK

Length:48

Mass (Da):5,686

Last modified:March 8, 2011 - v1

Checksum:ⁱD6FFF9D311A5ED02

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	P08183	MDR1_HUMAN		Multidrug resistance protein 1 Multidrug resistance protein 1, EC 7.6.2.2 (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD antigen CD243)	ABCB1 MDR1, PGY1	1,280	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	48	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC002457 Genomic DNA No translation available. AC005068 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC002457 Genomic DNA No translation available.
AC005068 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000416177; ENSP00000399419; ENSG00000085563
UCSC genome browser More...UCSCⁱ	uc064fbi.1 human

Protein	Similar proteins		Species	Score	Length	Source
E7EWT8	ABCB1 isoform 1		PANTR		1280	UniRef100_A0A2J8LGL5
Multidrug resistance protein 1 (Fragment)		HUMAN		69
ABCB1 isoform 10 (Fragment)		PANTR		48
p-glycoprotein 1 (Fragment)		HUMAN		22
UPI00051269BD		PANTR		1392

Protein	Similar proteins		Species	Score	Length	Source
E7EWT8	Multidrug resistance protein 1	)	HUMAN		1280	UniRef90_P08183
Multidrug resistance p-glycoprotein		MACFA		1283
Multidrug resistance protein		MACMU		1283
Uncharacterized protein		FELCA		1282
Multidrug resistance protein 1		FELSI		1262
+129

Protein	Similar proteins		Species	Score	Length	Source
E7EWT8	Phosphatidylcholine translocator ABCB4		HUMAN		1286	UniRef50_P21439
Phosphatidylcholine translocator ABCB4		CRIGR		1281
Phosphatidylcholine translocator ABCB4		RAT		1278
Phosphatidylcholine translocator ABCB4		MOUSE		1276
ATP binding cassette subfamily B member 4		SAIBB		1324
+649

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC002457 Genomic DNA No translation available. AC005068 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC002457 Genomic DNA No translation available.
AC005068 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	E7EWT8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQBⁱ	E7EWT8
PeptideAtlasⁱ	E7EWT8
PRIDEⁱ	E7EWT8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000416177; ENSP00000399419; ENSG00000085563
UCSCⁱ	uc064fbi.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000085563.14
HGNCⁱ	HGNC:40 ABCB1
OpenTargetsⁱ	ENSG00000085563
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0055 Eukaryota COG1132 LUCA
GeneTreeⁱ	ENSGT00530000062896

Miscellaneous databases

ChiTaRSⁱ	ABCB1 human

ChiTaRSⁱ

ABCB1 human

Gene expression databases

Bgeeⁱ	ENSG00000085563 Expressed in 186 organ(s), highest expression level in right adrenal gland
ExpressionAtlasⁱ	E7EWT8 baseline and differential

Family and domain databases

ProtoNetⁱ	Search...

ProtoNetⁱ

Search...

Entry informationⁱ

Entry nameⁱ	E7EWT8_HUMAN
Accessionⁱ	E7EWT8Primary (citable) accession number: E7EWT8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 8, 2011
	Last sequence update:	March 8, 2011
	Last modified:	September 12, 2018
	This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB - E7EWT8 (E7EWT8_HUMAN)

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Multidrug resistance protein 1

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Names & Taxonomyⁱ

Organism-specific databases

Pathology & Biotechⁱ

Organism-specific databases

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Phylogenomic databases

Sequence (1+)ⁱ

Computationally mapped potential isoform sequencesⁱ

Experimental Info

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

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UniRef

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Supporting data

UniProtKB - E7EWT8 (E7EWT8_HUMAN)

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Multidrug resistance protein 1

ABCB1

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

UniProt is an ELIXIR core data resource

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Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ