UniProtKB - E7EWE1 (E7EWE1_HUMAN)
Protein
UFM1-activating enzyme
Gene
UBA5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ubiquitin-like modifier activating enzyme activity Source: InterPro
Keywordsi
Ligand | Metal-bindingARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: UFM1-activating enzymeARBA annotationAlternative name(s): Ubiquitin-like modifier-activating enzyme 5ARBA annotation |
Gene namesi | Name:UBA5Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000081307.12 |
HGNCi | HGNC:23230, UBA5 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane ARBA annotation
Golgi apparatus
- Golgi apparatus ARBA annotation
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Other locations
- intracellular membrane-bounded organelle Source: HPA
PTM / Processingi
Proteomic databases
EPDi | E7EWE1 |
MaxQBi | E7EWE1 |
PeptideAtlasi | E7EWE1 |
PRIDEi | E7EWE1 |
ProteomicsDBi | 18828 |
Expressioni
Gene expression databases
Bgeei | ENSG00000081307, Expressed in body of pancreas and 231 other tissues |
ExpressionAtlasi | E7EWE1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 308 | ThiFInterPro annotationAdd BLAST | 256 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 5 – 25 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156177 |
HOGENOMi | CLU_013325_0_1_1 |
Family and domain databases
InterProi | View protein in InterPro IPR029752, D-isomer_DH_CS1 IPR000594, ThiF_NAD_FAD-bd IPR035985, Ubiquitin-activating_enz |
Pfami | View protein in Pfam PF00899, ThiF, 1 hit |
SUPFAMi | SSF69572, SSF69572, 1 hit |
PROSITEi | View protein in PROSITE PS00065, D_2_HYDROXYACID_DH_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
E7EWE1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAESVERLQQ RVQELERELA QERSLQVPRS GDGGGGRVRI EKMSSEVVDS
60 70 80 90 100
NPYSRLMALK RMGIVSDYEK IRTFAVAIVG VGGVGSVTAE MLTRCGIGKL
110 120 130 140 150
LLFDYDKVEL ANMNRLFFQP HQAGLSKVQA AEHTLRNINP DVLFEVHNYN
160 170 180 190 200
ITTVENFQHF MDRISNGGLE EGKPVDLVLS CVDNFEARMT INTACNELGQ
210 220 230 240 250
TWMESGVSEN AVSGHIQLII PGESACFACA PPLVVAANID EKTLKREGVC
260 270 280 290 300
AASLPTTMGV VAGILVQNVL KFLLNFGTVS FYLGYNAMQD FFPTMSMKPN
310 320 330 340
PQCDDRNCRK QQEEYKKKVA ALPKQEVIQE EEEIIHEDNE WARRFCH
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9GZZ9 | UBA5_HUMAN | Ubiquitin-like modifier-activating ... | UBA5 UBE1DC1 | 404 | Annotation score: | ||
E7EQ61 | E7EQ61_HUMAN | UFM1-activating enzyme | UBA5 | 377 | Annotation score: | ||
C9J5W5 | C9J5W5_HUMAN | UFM1-activating enzyme | UBA5 | 108 | Annotation score: | ||
C9J0F6 | C9J0F6_HUMAN | UFM1-activating enzyme | UBA5 | 79 | Annotation score: | ||
C9JRV9 | C9JRV9_HUMAN | Ubiquitin-like modifier-activating ... | UBA5 | 110 | Annotation score: | ||
D6RJC9 | D6RJC9_HUMAN | Ubiquitin-like modifier-activating ... | UBA5 | 64 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC020632 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000473651; ENSP00000424984; ENSG00000081307 |
UCSCi | uc062nxs.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC020632 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
EPDi | E7EWE1 |
MaxQBi | E7EWE1 |
PeptideAtlasi | E7EWE1 |
PRIDEi | E7EWE1 |
ProteomicsDBi | 18828 |
Protocols and materials databases
Antibodypediai | 2258, 152 antibodies |
Genome annotation databases
Ensembli | ENST00000473651; ENSP00000424984; ENSG00000081307 |
UCSCi | uc062nxs.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000081307.12 |
HGNCi | HGNC:23230, UBA5 |
OpenTargetsi | ENSG00000081307 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156177 |
HOGENOMi | CLU_013325_0_1_1 |
Miscellaneous databases
ChiTaRSi | UBA5, human |
Gene expression databases
Bgeei | ENSG00000081307, Expressed in body of pancreas and 231 other tissues |
ExpressionAtlasi | E7EWE1, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR029752, D-isomer_DH_CS1 IPR000594, ThiF_NAD_FAD-bd IPR035985, Ubiquitin-activating_enz |
Pfami | View protein in Pfam PF00899, ThiF, 1 hit |
SUPFAMi | SSF69572, SSF69572, 1 hit |
PROSITEi | View protein in PROSITE PS00065, D_2_HYDROXYACID_DH_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7EWE1_HUMAN | |
Accessioni | E7EWE1Primary (citable) accession number: E7EWE1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |