Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 49 (08 May 2019)
Sequence version 2 (28 Jun 2011)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Proline-rich basic protein 1

Gene

PROB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proline-rich basic protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PROB1
Synonyms:C5orf65
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:41906 PROB1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_E7EW31

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000228672

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PROB1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004136931 – 1015Proline-rich basic protein 1Add BLAST1015

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E7EW31

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E7EW31

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
E7EW31

PRoteomics IDEntifications database

More...
PRIDEi
E7EW31

ProteomicsDB human proteome resource

More...
ProteomicsDBi
18759

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E7EW31

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
E7EW31

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000228672 Expressed in 89 organ(s), highest expression level in muscle of leg

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA060103

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000416033

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 228Pro-richAdd BLAST222
Compositional biasi373 – 1007Pro-richAdd BLAST635

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZ44 Eukaryota
ENOG410XR03 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111496

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000170924

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
E7EW31

Identification of Orthologs from Complete Genome Data

More...
OMAi
QFECVEV

Database of Orthologous Groups

More...
OrthoDBi
226448at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
E7EW31

TreeFam database of animal gene trees

More...
TreeFami
TF343894

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027838 DUF4585

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15232 DUF4585, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7EW31-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTALAPPAL PGIPRQLPTA PARRQDSSGS SGSYYTAPGS PEPPDVGPDA
60 70 80 90 100
KGPANWPWVA PGRGAGAQPR LSVSAQNSRQ RHGPGSGFPR GPGSGPRPPQ
110 120 130 140 150
PQLRTLPSGE MEVIFGVGPL FGCSGADDRE AQQQFTEPAF ISPLPPGPAS
160 170 180 190 200
PAAVPRQSQV PDGGSRWATY LELRPRGPSP AAPAQFECVE VALEEGAAPA
210 220 230 240 250
RPRTVPKRQI ELRPRPQSPP RAAGAPRPRL LLRTGSLDES LGPLQAAAGF
260 270 280 290 300
VQTALARKLS PEAPAPSSAT FGSTGRSEPE TRETARSTHV VLEKAKSRPL
310 320 330 340 350
RVRDNSAPAK APRPWPSLRE RAIRRDKPAP GTEPLGPVSS SIFLQSEEKI
360 370 380 390 400
QEARKTRFPR EAPDRTVQRA RSPPFECRIP SEVPSRAVRP RSPSPPRQTP
410 420 430 440 450
NGAVRGPRCP SPQNLSPWDR TTRRVSSPLF PEASSEWENQ NPAVEETVSR
460 470 480 490 500
RSPSPPILSQ WNQCVAGERS PSLEAPSLWE IPHSAVADAV EPRSSPSPPA
510 520 530 540 550
FFPWEAPDRP IGTWGPSPQE TWDPMGPGSS IAFTQEAQNG LTQEELAPPT
560 570 580 590 600
PSAPGTPEPT EMQSPSTREI SDLAFGGSQQ SPEVAAPEPP GSHPVGTLDA
610 620 630 640 650
DKCPEVLGPG EAASGRPRMA IPRPRDVRKL VKTTYAPGFP AGAQGSGLPA
660 670 680 690 700
PPADPCGEEG GESKTQEPPA LGPPAPAHYT SVFIKDFLPV VPHPYEPPEP
710 720 730 740 750
SFDTVARDAS QPNGVLRRRA ENSTAKPFKR TEIRLPGALA LGRRPEVTSR
760 770 780 790 800
VRARGPGGEN RDVEAQRLVP DGDGRTSPLG GARSSSQRSP VGPAGVRSPR
810 820 830 840 850
PGSPQMQASP SPGIAPKPKT PPTAPEPAAA VQAPLPREPL ALAGRTAPAQ
860 870 880 890 900
PRAASAPPTD RSPQSPSQGA RRQPGAAPLG KVLVDPESGR YYFVEAPRQP
910 920 930 940 950
RLRVLFDPES GQYVEVLLPP SSPGPPHRVY TPLALGLGLY PPAYGPIPSL
960 970 980 990 1000
SLPPSPGPQA LGSPQLPWVS EAGPLDGTYY LPVSGTPNPA PPLLLCAPPS
1010
SSGPTQPGKG SLFPL
Length:1,015
Mass (Da):106,917
Last modified:June 28, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BF1673A980B2609
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG64269 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAH14854 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti763V → A in BAG64269 (PubMed:14702039).Curated1
Sequence conflicti763V → A in BAH14854 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC135457 Genomic DNA No translation available.
AK303170 mRNA Translation: BAG64269.1 Different initiation.
AK316483 mRNA Translation: BAH14854.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54909.1

NCBI Reference Sequences

More...
RefSeqi
NP_001155018.1, NM_001161546.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000434752; ENSP00000416033; ENSG00000228672

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
389333

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:389333

UCSC genome browser

More...
UCSCi
uc011czc.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135457 Genomic DNA No translation available.
AK303170 mRNA Translation: BAG64269.1 Different initiation.
AK316483 mRNA Translation: BAH14854.1 Different initiation.
CCDSiCCDS54909.1
RefSeqiNP_001155018.1, NM_001161546.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000416033

PTM databases

iPTMnetiE7EW31
PhosphoSitePlusiE7EW31

Polymorphism and mutation databases

BioMutaiPROB1

Proteomic databases

EPDiE7EW31
jPOSTiE7EW31
PaxDbiE7EW31
PRIDEiE7EW31
ProteomicsDBi18759

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434752; ENSP00000416033; ENSG00000228672
GeneIDi389333
KEGGihsa:389333
UCSCiuc011czc.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
389333

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PROB1
HGNCiHGNC:41906 PROB1
HPAiHPA060103
neXtProtiNX_E7EW31
OpenTargetsiENSG00000228672

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZ44 Eukaryota
ENOG410XR03 LUCA
GeneTreeiENSGT00730000111496
HOGENOMiHOG000170924
InParanoidiE7EW31
OMAiQFECVEV
OrthoDBi226448at2759
PhylomeDBiE7EW31
TreeFamiTF343894

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PROB1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
389333

Protein Ontology

More...
PROi
PR:E7EW31

Gene expression databases

BgeeiENSG00000228672 Expressed in 89 organ(s), highest expression level in muscle of leg

Family and domain databases

InterProiView protein in InterPro
IPR027838 DUF4585
PfamiView protein in Pfam
PF15232 DUF4585, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPROB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7EW31
Secondary accession number(s): B4E007
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: June 28, 2011
Last modified: May 8, 2019
This is version 49 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again