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Protein

Integrin beta

Gene

ITGB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotation
Biological processCell adhesionUniRule annotation

Enzyme and pathway databases

SignaLinkiE7EVZ9

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:ITGB2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160255.16
HGNCiHGNC:6155 ITGB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160255

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_500321902723 – 166Integrin betaSequence analysisAdd BLAST144

Proteomic databases

MaxQBiE7EVZ9
PeptideAtlasiE7EVZ9
PRIDEiE7EVZ9

Expressioni

Gene expression databases

BgeeiENSG00000160255
ExpressionAtlasiE7EVZ9 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 74PSIInterPro annotationAdd BLAST51
Domaini32 – 166INBInterPro annotationAdd BLAST135

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, TransmembraneUniRule annotation

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015439 Integrin_bsu-2
IPR002369 Integrin_bsu_VWA
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF15 PTHR10082:SF15, 1 hit
PfamiView protein in Pfam
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit

Sequencei

Sequence statusi: Fragment.

E7EVZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN
60 70 80 90 100
FTGPGDPDSI RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP
110 120 130 140 150
QKVTLYLRPG QAAAFNVTFR RAKGYPIDLY YLMDLSYSML DDLRNVKKLG
160
GDLLRALNEI TESGRI
Length:166
Mass (Da):18,288
Last modified:March 8, 2011 - v1
Checksum:i74B92D6DE99BB7D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei166Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773603 Genomic DNA No translation available.
AL844907 Genomic DNA No translation available.
AL844908 Genomic DNA No translation available.
KC877928 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000523663; ENSP00000428503; ENSG00000160255
UCSCiuc062aue.1 human

Similar proteinsi

Entry informationi

Entry nameiE7EVZ9_HUMAN
AccessioniPrimary (citable) accession number: E7EVZ9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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