UniProtKB - E7EVW7 (E7EVW7_HUMAN)
Protein
Submitted name:
Hematopoietic lineage cell-specific protein
Gene
HCLS1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: InterPro
GO - Biological processi
- actin filament polymerization Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Hematopoietic lineage cell-specific proteinImported |
Gene namesi | Name:HCLS1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4844, HCLS1 |
VEuPathDBi | HostDB:ENSG00000180353.10 |
PTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
EPDi | E7EVW7 |
MaxQBi | E7EVW7 |
PeptideAtlasi | E7EVW7 |
PRIDEi | E7EVW7 |
ProteomicsDBi | 18716 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180353, Expressed in blood and 205 other tissues |
ExpressionAtlasi | E7EVW7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 391 – 449 | SH3InterPro annotationAdd BLAST | 59 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 206 – 382 | DisorderedSequence analysisAdd BLAST | 177 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 206 – 237 | PolyampholyteSequence analysisAdd BLAST | 32 | |
Compositional biasi | 319 – 366 | AcidicSequence analysisAdd BLAST | 48 |
Keywords - Domaini
RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158997 |
OMAi | HDYVAQV |
Family and domain databases
InterProi | View protein in InterPro IPR028534, HS1 IPR003134, Hs1_Cortactin IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR10829:SF5, PTHR10829:SF5, 2 hits |
Pfami | View protein in Pfam PF02218, HS1_rep, 3 hits PF00018, SH3_1, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51090, CORTACTIN, 3 hits PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
E7EVW7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE
60 70 80 90 100
HINIHQLRNK VSEEHDVLRK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG
110 120 130 140 150
HEYVAEVEKH SSQTDAAKGF GGKYGVERDR ADKSAVGFDY KGEVEKHTSQ
160 170 180 190 200
KDYAKGFGGQ YGIQKDRVDK SAVGFNEMEA PTTAYKKTTP IEAASSGTRG
210 220 230 240 250
LKAKFESMAE EKRKREEEEK AQQVARRQQE RKAVTKRSPE APQPVIAMEE
260 270 280 290 300
PAVPAPLPKK ISSEAWPPVG TPPSSESEPV RTSREHPVPL LPIRQTLPED
310 320 330 340 350
NEEPPALPPR TLEGLQVEEE PVYEAEPEPE PEPEPEPEND YEDVEEMDRH
360 370 380 390 400
EQEDEPEGDY EEVLEPEDSS FSSALAGSSG CPAGAGAGAV ALGISAVAVY
410 420 430 440
DYQGEGSDEL SFDPDDVITD IEMVDEGWWR GRCHGHFGLF PANYVKLLE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP14317 | HCLS1_HUMAN | Hematopoietic lineage cell-specific... | HCLS1 HS1 | 486 | Annotation score: | ||
F8WEZ6 | F8WEZ6_HUMAN | Hematopoietic lineage cell-specific... | HCLS1 | 76 | Annotation score: | ||
F8WDD5 | F8WDD5_HUMAN | Hematopoietic lineage cell-specific... | HCLS1 | 75 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC133750 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000428394; ENSP00000387645; ENSG00000180353 |
UCSCi | uc011bjj.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC133750 Genomic DNA No translation available. |
3D structure databases
SMRi | E7EVW7 |
ModBasei | Search... |
Proteomic databases
EPDi | E7EVW7 |
MaxQBi | E7EVW7 |
PeptideAtlasi | E7EVW7 |
PRIDEi | E7EVW7 |
ProteomicsDBi | 18716 |
Protocols and materials databases
Antibodypediai | 16699, 471 antibodies |
Genome annotation databases
Ensembli | ENST00000428394; ENSP00000387645; ENSG00000180353 |
UCSCi | uc011bjj.3, human |
Organism-specific databases
HGNCi | HGNC:4844, HCLS1 |
OpenTargetsi | ENSG00000180353 |
VEuPathDBi | HostDB:ENSG00000180353.10 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158997 |
OMAi | HDYVAQV |
Miscellaneous databases
ChiTaRSi | HCLS1, human |
Gene expression databases
Bgeei | ENSG00000180353, Expressed in blood and 205 other tissues |
ExpressionAtlasi | E7EVW7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR028534, HS1 IPR003134, Hs1_Cortactin IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR10829:SF5, PTHR10829:SF5, 2 hits |
Pfami | View protein in Pfam PF02218, HS1_rep, 3 hits PF00018, SH3_1, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51090, CORTACTIN, 3 hits PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7EVW7_HUMAN | |
Accessioni | E7EVW7Primary (citable) accession number: E7EVW7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | April 7, 2021 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |