UniProtKB - E7EVW1 (E7EVW1_HUMAN)
Protein
Submitted name:
Blood group Rh(D) polypeptide
Gene
RHD
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Blood group Rh(D) polypeptideImported |
Gene namesi | Name:RHDImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000187010.18 |
HGNCi | HGNC:10009, RHD |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 31 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 77 – 94 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 106 – 127 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 139 – 157 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 169 – 188 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 200 – 220 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 240 – 259 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 292 – 312 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 332 – 349 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000187010, Expressed in trabecular bone tissue and 126 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 350 | Ammonium_transpInterPro annotationAdd BLAST | 331 |
Sequence similaritiesi
Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. [View classification]ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG3796, Eukaryota |
GeneTreei | ENSGT00950000182844 |
Family and domain databases
Gene3Di | 1.10.3430.10, 1 hit |
InterProi | View protein in InterPro IPR029020, Ammonium/urea_transptr IPR024041, NH4_transpt_AmtB-like_dom IPR002229, RhesusRHD |
Pfami | View protein in Pfam PF00909, Ammonium_transp, 1 hit |
PRINTSi | PR00342, RHESUSRHD |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
E7EVW1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSKYPRSVR RCLPLWALTL EAALILLFYF FTHYDASLED QKGLVASYQV
60 70 80 90 100
GQDLTVMAAI GLGFLTSSFR RHSWSSVAFN LFMLALGVQW AILLDGFLSQ
110 120 130 140 150
FPSGKVVITL FSIRLATMSA LSVLISVDAV LGKVNLAQLV VMVLVEVTAL
160 170 180 190 200
GNLRMVISNI FNTDYHMNMM HIYVFAAYFG LSVAWCLPKP LPEGTEDKDQ
210 220 230 240 250
TATIPSLSAM LGALFLWMFW PSFNSALLRS PIERKNAVFN TYYAVAVSVV
260 270 280 290 300
TAISGSSLAH PQGKISKTYV HSAVLAGGVA VGTSCHLIPS PWLAMVLGLV
310 320 330 340 350
AGLISVGGAK YLPGCCNRVL GIPHSSIMGY NFSLLGLLGE IIYIVLLVLD
360 370 380 390 400
TVGAGNGMSL GWNLAVKMAE AGDEELMRLD VSQRNHGGAA VPTGSWMPST
410 420 430
ETTIAPNYRD HISVGLASRS SSALGNSAWP S
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ02161 | RHD_HUMAN | Blood group Rh(D) polypeptide | RHD | 417 | Annotation score: | ||
A0A3B3IU43 | A0A3B3IU43_HUMAN | Blood group Rh(D) polypeptide | RHD | 345 | Annotation score: | ||
H3BT10 | H3BT10_HUMAN | Blood group Rh(D) polypeptide | RHD | 463 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL928711 Genomic DNA No translation available. |
RefSeqi | NP_001269801.1, NM_001282872.1 |
Genome annotation databases
Ensembli | ENST00000423810; ENSP00000399640; ENSG00000187010 ENST00000622561; ENSP00000478087; ENSG00000187010 |
GeneIDi | 6007 |
UCSCi | uc001bkb.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL928711 Genomic DNA No translation available. |
RefSeqi | NP_001269801.1, NM_001282872.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000339577 |
Proteomic databases
ProteomicsDBi | 18714 |
Protocols and materials databases
Antibodypediai | 30382, 190 antibodies |
Genome annotation databases
Ensembli | ENST00000423810; ENSP00000399640; ENSG00000187010 ENST00000622561; ENSP00000478087; ENSG00000187010 |
GeneIDi | 6007 |
UCSCi | uc001bkb.5, human |
Organism-specific databases
CTDi | 6007 |
EuPathDBi | HostDB:ENSG00000187010.18 |
HGNCi | HGNC:10009, RHD |
OpenTargetsi | ENSG00000187010 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3796, Eukaryota |
GeneTreei | ENSGT00950000182844 |
Miscellaneous databases
BioGRID-ORCSi | 6007, 5 hits in 841 CRISPR screens |
ChiTaRSi | RHD, human |
GenomeRNAii | 6007 |
Gene expression databases
Bgeei | ENSG00000187010, Expressed in trabecular bone tissue and 126 other tissues |
Family and domain databases
Gene3Di | 1.10.3430.10, 1 hit |
InterProi | View protein in InterPro IPR029020, Ammonium/urea_transptr IPR024041, NH4_transpt_AmtB-like_dom IPR002229, RhesusRHD |
Pfami | View protein in Pfam PF00909, Ammonium_transp, 1 hit |
PRINTSi | PR00342, RHESUSRHD |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7EVW1_HUMAN | |
Accessioni | E7EVW1Primary (citable) accession number: E7EVW1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | December 2, 2020 | |
This is version 75 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |