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Entry version 71 (02 Jun 2021)
Sequence version 2 (29 Oct 2014)
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Protein

Piezo-type mechanosensitive ion channel component

Gene

PIEZO2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channelUniRule annotationARBA annotation
Biological processIon transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Piezo-type mechanosensitive ion channel componentUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIEZO2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26270, PIEZO2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000154864.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 33HelicalUniRule annotationAdd BLAST22
Transmembranei69 – 89HelicalUniRule annotationAdd BLAST21
Transmembranei163 – 181HelicalUniRule annotationAdd BLAST19
Transmembranei187 – 208HelicalUniRule annotationAdd BLAST22
Transmembranei215 – 238HelicalUniRule annotationAdd BLAST24
Transmembranei464 – 482HelicalUniRule annotationAdd BLAST19
Transmembranei494 – 512HelicalUniRule annotationAdd BLAST19
Transmembranei532 – 550HelicalUniRule annotationAdd BLAST19
Transmembranei627 – 647HelicalUniRule annotationAdd BLAST21
Transmembranei653 – 672HelicalUniRule annotationAdd BLAST20
Transmembranei684 – 703HelicalUniRule annotationAdd BLAST20
Transmembranei736 – 757HelicalUniRule annotationAdd BLAST22
Transmembranei881 – 901HelicalUniRule annotationAdd BLAST21
Transmembranei907 – 925HelicalUniRule annotationAdd BLAST19
Transmembranei932 – 951HelicalUniRule annotationAdd BLAST20
Transmembranei1004 – 1025HelicalUniRule annotationAdd BLAST22
Transmembranei1068 – 1086HelicalUniRule annotationAdd BLAST19
Transmembranei1092 – 1108HelicalUniRule annotationAdd BLAST17
Transmembranei1120 – 1141HelicalUniRule annotationAdd BLAST22
Transmembranei1176 – 1194HelicalUniRule annotationAdd BLAST19
Transmembranei1242 – 1258HelicalUniRule annotationAdd BLAST17
Transmembranei1264 – 1287HelicalUniRule annotationAdd BLAST24
Transmembranei1299 – 1323HelicalUniRule annotationAdd BLAST25
Transmembranei1858 – 1881HelicalUniRule annotationAdd BLAST24
Transmembranei1887 – 1908HelicalUniRule annotationAdd BLAST22
Transmembranei1915 – 1933HelicalUniRule annotationAdd BLAST19
Transmembranei2140 – 2162HelicalUniRule annotationAdd BLAST23
Transmembranei2182 – 2202HelicalUniRule annotationAdd BLAST21
Transmembranei2211 – 2229HelicalUniRule annotationAdd BLAST19
Transmembranei2241 – 2259HelicalUniRule annotationAdd BLAST19
Transmembranei2280 – 2301HelicalUniRule annotationAdd BLAST22
Transmembranei2313 – 2332HelicalUniRule annotationAdd BLAST20
Transmembranei2353 – 2377HelicalUniRule annotationAdd BLAST25
Transmembranei2613 – 2636HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000154864

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
E7EVM7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
18674

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154864, Expressed in lung and 200 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7EVM7, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1318 – 1551PIEZOInterPro annotationAdd BLAST234
Domaini2291 – 2700Piezo_RRas_bdgInterPro annotationAdd BLAST410

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni395 – 427DisorderedSequence analysisAdd BLAST33
Regioni572 – 613DisorderedSequence analysisAdd BLAST42
Regioni811 – 851DisorderedSequence analysisAdd BLAST41
Regioni1439 – 1485DisorderedSequence analysisAdd BLAST47
Regioni1544 – 1587DisorderedSequence analysisAdd BLAST44
Regioni1795 – 1819DisorderedSequence analysisAdd BLAST25
Regioni1998 – 2020DisorderedSequence analysisAdd BLAST23
Regioni2041 – 2086DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi408 – 422Acidic residuesSequence analysisAdd BLAST15
Compositional biasi575 – 596Acidic residuesSequence analysisAdd BLAST22
Compositional biasi597 – 611Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi811 – 832Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi833 – 850Acidic residuesSequence analysisAdd BLAST18
Compositional biasi1461 – 1485Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi1547 – 1561Basic residuesSequence analysisAdd BLAST15
Compositional biasi1562 – 1587Basic and acidic residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PIEZO (TC 1.A.75) family. [View classification]UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154456

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000512_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSREKMI

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027272, Piezo
IPR031805, Piezo_dom
IPR031334, Piezo_RRas-bd_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13167, PTHR13167, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15917, PIEZO, 1 hit
PF12166, Piezo_RRas_bdg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

E7EVM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGHTGRLLK SLCFISLSFL LLHIIFHITL VSLEAQHRIA PGYNCSTWEK
60 70 80 90 100
TFRQIGFESL KGADAGNGIR VFVPDIGMFI ASLTIWLLCR NIVQKPVTDE
110 120 130 140 150
AAQSNPEFEN EELAEGEKID SEEALIYEED FNGGDGVEGE LEESTKLKMF
160 170 180 190 200
RRLASVASKL KEFIGNMITT AGKVVVTILL GSSGMMLPSL TSSVYFFVFL
210 220 230 240 250
GLCTWWSWCR TFDPLLFSCL CVLLAIFTAG HLIGLYLYQF QFFQEAVPPN
260 270 280 290 300
DYYARLFGIK SVIQTDCSST WKIIVNPDLS WYHHANPILL LVMYYTLATL
310 320 330 340 350
IRIWLQEPLV QDEGTKEEDK ALACSPIQIT AGRRRSLWYA THYPTDERKL
360 370 380 390 400
LSMTQDDYKP SDGLLVTVNG NPVDYHTIHP SLPMENGPGK ADLYSTPQYR
410 420 430 440 450
WEPSDESSEK REEEEEEKEE FEEERSREEK RSIKVHAMVS VFQFIMKQSY
460 470 480 490 500
ICALIAMMAW SITYHSWLTF VLLIWSCTLW MIRNRRKYAM ISSPFMVVYG
510 520 530 540 550
NLLLILQYIW SFELPEIKKV PGFLEKKEPG ELASKILFTI TFWLLLRQHL
560 570 580 590 600
TEQKALQEKE ALLSEVKIGS QENEEKDEEL QDIQVEGEPK EEEEEEAKEE
610 620 630 640 650
KQERKKVEQE EAEEEDEQDI MKVLGNLVVA MFIKYWIYVC GGMFFFVSFE
660 670 680 690 700
GKIVMYKIIY MVLFLFCVAL YQVHYEWWRK ILKYFWMSVV IYTMLVLIFI
710 720 730 740 750
YTYQFENFPG LWQNMTGLKK EKLEDLGLKQ FTVAELFTRI FIPTSFLLVC
760 770 780 790 800
ILHLHYFHDR FLELTDLKSI PSKEDNTIYR LAHPEGSLPD LTMMHLTASL
810 820 830 840 850
EKPEVRKLAE PGEEKLEGYS EKAQKGDLGK DSEESEEDGE EEEESEEEEE
860 870 880 890 900
TSDLRNKWHL VIDRLTVLFL KFLEYFHKLQ VFMWWILELH IIKIVSSYII
910 920 930 940 950
WVSVKEARVS LFNYVFLISW AFALPYAKLR RLASSVCTVW TCVIIVCKML
960 970 980 990 1000
YQLQTIKPEN FSVNCSLPNE NQTNIPFNEL NKSLLYSAPI DPTEWVGLRK
1010 1020 1030 1040 1050
SSPLLVYLRN NLLMLAILAF EVTIYRHQEY YRGRNNLTAP VSRTIFHDIT
1060 1070 1080 1090 1100
RLHLDDGLIN CAKYFINYFF YKFGLETCFL MSVNVIGQRM DFYAMIHACW
1110 1120 1130 1140 1150
LIAVLYRRRR KAIAEIWPKY CCFLACIITF QYFICIGIPP APCRDYPWRF
1160 1170 1180 1190 1200
KGASFNDNII KWLYFPDFIV RPNPVFLVYD FMLLLCASLQ RQIFEDENKA
1210 1220 1230 1240 1250
AVRIMAGDNV EICMNLDAAS FSQHNPVPDF IHCRSYLDMS KVIIFSYLFW
1260 1270 1280 1290 1300
FVLTIIFITG TTRISIFCMG YLVACFYFLL FGGDLLLKPI KSILRYWDWL
1310 1320 1330 1340 1350
IAYNVFVITM KNILSIGACG YIGTLVHNSC WLIQAFSLAC TVKGYQMPAA
1360 1370 1380 1390 1400
NSPCTLPSGE AGIIWDSICF AFLLLQRRVF MSYYFLHVVA DIKASQILAS
1410 1420 1430 1440 1450
RGAELFQATI VKAVKARIEE EKKSMDQLKR QMDRIKARQQ KYKKGKERML
1460 1470 1480 1490 1500
SLTQEPGEGQ DMQKLSEEDD EREADKQKAK GKKKQWWRPW VDHASMVRSG
1510 1520 1530 1540 1550
DYYLFETDSE EEEEEELKKE DEEPPRRSAF QFVYQAWITD PKTALRQRHK
1560 1570 1580 1590 1600
EKKRSAREER KRRRKGSKEG PVEWEDREDE PIKKKSDGPD NIIKRIFNIL
1610 1620 1630 1640 1650
KFTWVLFLAT VDSFTTWLNS ISREHIDIST VLRIERCMLT REIKKGNVPT
1660 1670 1680 1690 1700
RESIHMYYQN HIMNLSRESG LDTIDEHPGA ASGAQTAHRM DSLDSHDSIS
1710 1720 1730 1740 1750
SEPTQCTMLY SRQGTTETIE EVEAEQEEEA GSTAPEPREA KEYEATGYDV
1760 1770 1780 1790 1800
GAMGAEEASL TPEEELTQFS TLDGDVEAPP SYSKAVSFEH LSFGSQDDSA
1810 1820 1830 1840 1850
GKNRMAVSPD DSRTDKLGSS ILPPLTHELT ASELLLKKMF HDDELEESEK
1860 1870 1880 1890 1900
FYVGQPRFLL LFYAMYNTLV ARSEMVCYFV IILNHMVSAS MITLLLPILI
1910 1920 1930 1940 1950
FLWAMLSVPR PSRRFWMMAI VYTEVAIVVK YFFQFGFFPW NKNVEVNKDK
1960 1970 1980 1990 2000
PYHPPNIIGV EKKEGYVLYD LIQLLALFFH RSILKCHGLW DEDDMTESGM
2010 2020 2030 2040 2050
AREESDDELS LGHGRRDSSD SLKSINLAAS VESVHVTFPE QQTAVRRKRS
2060 2070 2080 2090 2100
GSSSEPSQRS SFSSNRSQRG STSTRNSSQK GSSVLSIKQK GKRELYMEKL
2110 2120 2130 2140 2150
QEHLIKAKAF TIKKTLEIYV PIKQFFYNLI HPEYSAVTDV YVLMFLADTV
2160 2170 2180 2190 2200
DFIIIVFGFW AFGKHSAAAD ITSSLSEDQV PGPFLVMVLI QFGTMVVDRA
2210 2220 2230 2240 2250
LYLRKTVLGK VIFQVILVFG IHFWMFFILP GVTERKFSQN LVAQLWYFVK
2260 2270 2280 2290 2300
CVYFGLSAYQ IRCGYPTRVL GNFLTKSYNY VNLFLFQGFR LVPFLTELRA
2310 2320 2330 2340 2350
VMDWVWTDTT LSLSSWICVE DIYAHIFILK CWRESEKRYP QPRGQKKKKV
2360 2370 2380 2390 2400
VKYGMGGMII VLLICIVWFP LLFMSLIKSV AGVINQPLDV SVTITLGGYQ
2410 2420 2430 2440 2450
PIFTMSAQQS QLKVMDQQSF NKFIQAFSRD TGAMQFLENY EKEDITVAEL
2460 2470 2480 2490 2500
EGNSNSLWTI SPPSKQKMIH ELLDPNSSFS VVFSWSIQRN LSLGAKSEIA
2510 2520 2530 2540 2550
TDKLSFPLKN ITRKNIAKMI AGNSTESSKT PVTIEKIYPY YVKAPSDSNS
2560 2570 2580 2590 2600
KPIKQLLSEN NFMDITIILS RDNTTKYNSE WWVLNLTGNR IYNPNSQALE
2610 2620 2630 2640 2650
LVVFNDKVSP PSLGFLAGYG IMGLYASVVL VIGKFVREFF SGISHSIMFE
2660 2670 2680 2690 2700
ELPNVDRILK LCTDIFLVRE TGELELEEDL YAKLIFLYRS PETMIKWTRE

KTN
Length:2,703
Mass (Da):312,611
Last modified:October 29, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60EA10A46FB9D753
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9H5I5PIEZ2_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2 C18orf30, C18orf58, FAM38B
2,752Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2H4UKA7A0A2H4UKA7_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
2,865Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRQ5J3KRQ5_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
1,473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GZ18V9GZ18_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y3N5A0A2R8Y3N5_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLJ9J3QLJ9_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRW1J3KRW1_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YG64A0A2R8YG64_HUMAN
Piezo-type mechanosensitive ion cha...
PIEZO2
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP001180 Genomic DNA No translation available.
AP005117 Genomic DNA No translation available.
AP005120 Genomic DNA No translation available.
AP005404 Genomic DNA No translation available.
AP005793 Genomic DNA No translation available.
KF456344 Genomic DNA No translation available.
KF510432 Genomic DNA No translation available.
KF510433 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000383408; ENSP00000372900; ENSG00000154864

UCSC genome browser

More...
UCSCi
uc060nji.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001180 Genomic DNA No translation available.
AP005117 Genomic DNA No translation available.
AP005120 Genomic DNA No translation available.
AP005404 Genomic DNA No translation available.
AP005793 Genomic DNA No translation available.
KF456344 Genomic DNA No translation available.
KF510432 Genomic DNA No translation available.
KF510433 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiE7EVM7
ProteomicsDBi18674

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2900, 206 antibodies

Genome annotation databases

EnsembliENST00000383408; ENSP00000372900; ENSG00000154864
UCSCiuc060nji.1, human

Organism-specific databases

HGNCiHGNC:26270, PIEZO2
OpenTargetsiENSG00000154864
VEuPathDBiHostDB:ENSG00000154864.11

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00940000154456
HOGENOMiCLU_000512_0_0_1
OMAiPSREKMI

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PIEZO2, human

Gene expression databases

BgeeiENSG00000154864, Expressed in lung and 200 other tissues
ExpressionAtlasiE7EVM7, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR027272, Piezo
IPR031805, Piezo_dom
IPR031334, Piezo_RRas-bd_dom
PANTHERiPTHR13167, PTHR13167, 1 hit
PfamiView protein in Pfam
PF15917, PIEZO, 1 hit
PF12166, Piezo_RRas_bdg, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7EVM7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7EVM7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: October 29, 2014
Last modified: June 2, 2021
This is version 71 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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