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Entry version 58 (22 Apr 2020)
Sequence version 1 (08 Mar 2011)
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Protein

Cytoplasmic FMR1-interacting protein

Gene

CYFIP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic FMR1-interacting proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYFIP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000055163.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13760 CYFIP2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000055163

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
E7EVJ5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
E7EVJ5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E7EVJ5

PeptideAtlas

More...
PeptideAtlasi
E7EVJ5

PRoteomics IDEntifications database

More...
PRIDEi
E7EVJ5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
18652

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000055163 Expressed in renal medulla and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7EVJ5 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CYFIP family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3534 Eukaryota
ENOG410XPKW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044831

TreeFam database of animal gene trees

More...
TreeFami
TF312925

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008081 Cytoplasmic_FMR1-int
IPR009828 DUF1394

The PANTHER Classification System

More...
PANTHERi
PTHR12195 PTHR12195, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07159 DUF1394, 1 hit
PF05994 FragX_IP, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF008153 FMR1_interacting, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01698 CYTOFMRPINTP

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

E7EVJ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTHVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSIMYQA NFDTNFEDRN
60 70 80 90 100
AFVTGIARYI EQATVHSSMV KCNEQPNRVE IYEKTVEVLE PEVTKLMKFM
110 120 130 140 150
YFQRKAIERF CSEVKRLCHA ERRKDFVSEA YLLTLGKFIN MFAVLDELKN
160 170 180 190 200
MKCSVKNDHS AYKRAAQFLR KMADPQSIQE SQNLSMFLAN HNRITQCLHQ
210 220 230 240 250
QLEVIPGYEE LLADIVNICV DYYENKMYLT PSEKHMLLKV MGFGLYLMDG
260 270 280 290 300
NVSNIYKLDA KKRINLSKID KFFKQLQVVP LFGDMQIELA RYIKTSAHYE
310 320 330 340 350
ENKSKWTCTQ SSISPQYNIC EQMVQIRDDH IRFISELARY SNSEVVTGSG
360 370 380 390 400
LDSQKSDEEY RELFDLALRG LQLLSKWSAH VMEVYSWKLV HPTDKFCNKD
410 420 430 440 450
CPGTAEEYER ATRYNYTSEE KFAFVEVIAM IKGLQVLMGR MESVFNQAIR
460 470 480 490 500
NTIYAALQDF AQVTLREPLR QAVRKKKNVL ISVLQAIRKT ICDWEGGREP
510 520 530 540 550
PNDPCLRGEK DPKGGFDIKV PRRAVGPSST QLYMVRTMLE SLIADKSGSK
560 570 580 590 600
KTLRSSLDGP IVLAIEDFHK QSFFFTHLLN ISEALQQCCD LSQLWFREFF
610 620 630 640 650
LELTMGRRIQ FPIEMSMPWI LTDHILETKE PSMMEYVLYP LDLYNDSAYY
660 670 680 690 700
ALTKFKKQFL YDEIEAEVNL CFDQFVYKLA DQIFAYYKAM AGSVLLDKRF
710 720 730 740 750
RAECKNYGVI IPYPPSNRYE TLLKQRHVQL LGRSIDLNRL ITQRISAAMY
760 770 780 790 800
KSLDQAISRF ESEDLTSIVE LEWLLEINRL THRLLCKHMT LDSFDAMFRE
810 820 830 840 850
ANHNVSAPYG RITLHVFWEL NFDFLPNYCY NGSTNRFVRT AIPFTQEPQR
860 870 880 890 900
DKPANVQPYY LYGSKPLNIA YSHIYSSYRN FVGPPHFKTI CRLLGYQGIA
910 920 930 940 950
VVMEELLKIV KSLLQGTILQ YVKTLIEVMP KICRLPRHEY GSPGILEFFH
960 970 980 990 1000
HQLKDIIEYA ELKTDVFQSL REVGNAILFC LLIEQALSQE EVCDLLHAAP
1010 1020 1030 1040 1050
FQNILPRVYI KEGERLEVRM KRLEAKYAPL HLVPLIERLG TPQQIAIARE
1060 1070 1080 1090 1100
GDLLTKERLC CGLSMFEVIL TRIRSYLQDP IWRGPPPTNG VMHVDECVEF
1110 1120 1130 1140 1150
HRLWSAMQFV YCIPVGTNEF TAEQCFGDGL NWAGCSIIVL LGQQRRFDLF
1160 1170 1180 1190 1200
DFCYHLLKVQ RQDGKDEIIK NVPLKKMADR IRKYQILNNE VFAILNKYMK
1210 1220
SVETDSSTVE HVRCFQPPIH QSLATTC
Length:1,227
Mass (Da):142,577
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i497CC1C4B258515C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96F07CYFP2_HUMAN
Cytoplasmic FMR1-interacting protei...
CYFIP2 KIAA1168, PIR121
1,278Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EW33E7EW33_HUMAN
Cytoplasmic FMR1-interacting protei...
CYFIP2
1,057Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTQ3A0A087WTQ3_HUMAN
Cytoplasmic FMR1-interacting protei...
CYFIP2
222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C229H7C229_HUMAN
Cytoplasmic FMR1-interacting protei...
CYFIP2
1,117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVE1A0A087WVE1_HUMAN
Cytoplasmic FMR1-interacting protei...
CYFIP2
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWZ1A0A087WWZ1_HUMAN
Cytoplasmic FMR1-interacting protei...
CYFIP2
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WV63A0A087WV63_HUMAN
Cytoplasmic FMR1-interacting protei...
CYFIP2
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZL7A0A087WZL7_HUMAN
Cytoplasmic FMR1-interacting protei...
CYFIP2
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RKA3E5RKA3_HUMAN
Cytoplasmic FMR1-interacting protei...
CYFIP2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC008676 Genomic DNA No translation available.
AC009185 Genomic DNA No translation available.
AC016571 Genomic DNA No translation available.
KF459628 Genomic DNA No translation available.
KF510898 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001278650.1, NM_001291721.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000521420; ENSP00000430904; ENSG00000055163

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
26999

UCSC genome browser

More...
UCSCi
uc011ddn.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008676 Genomic DNA No translation available.
AC009185 Genomic DNA No translation available.
AC016571 Genomic DNA No translation available.
KF459628 Genomic DNA No translation available.
KF510898 Genomic DNA No translation available.
RefSeqiNP_001278650.1, NM_001291721.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiE7EVJ5
jPOSTiE7EVJ5
MaxQBiE7EVJ5
PeptideAtlasiE7EVJ5
PRIDEiE7EVJ5
ProteomicsDBi18652

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
28408 138 antibodies

Genome annotation databases

EnsembliENST00000521420; ENSP00000430904; ENSG00000055163
GeneIDi26999
UCSCiuc011ddn.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26999
EuPathDBiHostDB:ENSG00000055163.18
HGNCiHGNC:13760 CYFIP2
OpenTargetsiENSG00000055163

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3534 Eukaryota
ENOG410XPKW LUCA
GeneTreeiENSGT00500000044831
TreeFamiTF312925

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CYFIP2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
26999

Gene expression databases

BgeeiENSG00000055163 Expressed in renal medulla and 230 other tissues
ExpressionAtlasiE7EVJ5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR008081 Cytoplasmic_FMR1-int
IPR009828 DUF1394
PANTHERiPTHR12195 PTHR12195, 2 hits
PfamiView protein in Pfam
PF07159 DUF1394, 1 hit
PF05994 FragX_IP, 1 hit
PIRSFiPIRSF008153 FMR1_interacting, 2 hits
PRINTSiPR01698 CYTOFMRPINTP

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7EVJ5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7EVJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: April 22, 2020
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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