UniProtKB - E7EVG2 (E7EVG2_HUMAN)
Protein
Submitted name:
Protein polybromo-1
Gene
PBRM1
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 1378 – 1428 | HMG boxPROSITE-ProRule annotationAdd BLAST | 51 |
GO - Molecular functioni
- chromatin binding Source: InterPro
- DNA binding Source: UniProtKB-UniRule
GO - Biological processi
- chromatin remodeling Source: InterPro
Keywordsi
Molecular function | DNA-bindingPROSITE-ProRule annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Protein polybromo-1Imported |
Gene namesi | Name:PBRM1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30064, PBRM1 |
VEuPathDBi | HostDB:ENSG00000163939.18 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleoplasm Source: HPA
- RSC-type complex Source: InterPro
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationPTM / Processingi
Proteomic databases
PaxDbi | E7EVG2 |
PeptideAtlasi | E7EVG2 |
PRIDEi | E7EVG2 |
ProteomicsDBi | 18633 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163939, Expressed in forebrain and 247 other tissues |
ExpressionAtlasi | E7EVG2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 134 | BromoInterPro annotationAdd BLAST | 71 | |
Domaini | 200 – 270 | BromoInterPro annotationAdd BLAST | 71 | |
Domaini | 400 – 470 | BromoInterPro annotationAdd BLAST | 71 | |
Domaini | 538 – 608 | BromoInterPro annotationAdd BLAST | 71 | |
Domaini | 676 – 746 | BromoInterPro annotationAdd BLAST | 71 | |
Domaini | 817 – 862 | BromoInterPro annotationAdd BLAST | 46 | |
Domaini | 955 – 1073 | BAHInterPro annotationAdd BLAST | 119 | |
Domaini | 1155 – 1271 | BAHInterPro annotationAdd BLAST | 117 | |
Domaini | 1378 – 1428 | HMG boxInterPro annotationAdd BLAST | 51 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 39 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 155 – 177 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 487 – 517 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 625 – 646 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 902 – 940 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 1105 – 1132 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1353 – 1377 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 21 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 625 – 639 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 902 – 932 | PolyampholyteSequence analysisAdd BLAST | 31 |
Keywords - Domaini
BromodomainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000003017 |
Family and domain databases
CDDi | cd05515, Bromo_polybromo_V, 1 hit |
Gene3Di | 1.20.920.10, 6 hits 2.30.30.490, 2 hits |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR037968, PBRM1_BD5 IPR037382, Rsc/polybromo |
PANTHERi | PTHR16062, PTHR16062, 2 hits |
Pfami | View protein in Pfam PF01426, BAH, 2 hits PF00439, Bromodomain, 6 hits PF00505, HMG_box, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00439, BAH, 2 hits SM00297, BROMO, 6 hits SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit SSF47370, SSF47370, 6 hits |
PROSITEi | View protein in PROSITE PS51038, BAH, 2 hits PS00633, BROMODOMAIN_1, 5 hits PS50014, BROMODOMAIN_2, 6 hits PS50118, HMG_BOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
E7EVG2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSKRRRATS PSSSVSGDFD DGHHSVSTPG PSRKRRRLSN LPTVDPIAVC
60 70 80 90 100
HELYNTIRDY KDEQGRLLCE LFIRAPKRRN QPDYYEVVSQ PIDLMKIQQK
110 120 130 140 150
LKMEEYDDVN LLTADFQLLF NNAKSYYKPD SPEYKAACKL WDLYLRTRNE
160 170 180 190 200
FVQKGEADDE DDDEDGQDNQ GTVTEGSSPA YLKEILEQLL EAIVVATNPS
210 220 230 240 250
GRLISELFQK LPSKVQYPDY YAIIKEPIDL KTIAQRIQNG SYKSIHAMAK
260 270 280 290 300
DIDLLAKNAK TYNEPGSQVF KDANSIKKIF YMKKAEIEHH EMAKSSLRMR
310 320 330 340 350
TPSNLAAARL TGPSHSKGSL GEERNPTSKY YRNKRAVQGG RLSAITMALQ
360 370 380 390 400
YGSESEEDAA LAAARYEEGE SEAESITSFM DVSNPFYQLY DTVRSCRNNQ
410 420 430 440 450
GQLIAEPFYH LPSKKKYPDY YQQIKMPISL QQIRTKLKNQ EYETLDHLEC
460 470 480 490 500
DLNLMFENAK RYNVPNSAIY KRVLKLQQVM QAKKKELARR DDIEDGDSMI
510 520 530 540 550
SSATSDTGSA KRKSKKNIRK QRMKILFNVV LEAREPGSGR RLCDLFMVKP
560 570 580 590 600
SKKDYPDYYK IILEPMDLKI IEHNIRNDKY AGEEGMIEDM KLMFRNARHY
610 620 630 640 650
NEEGSQVYND AHILEKLLKE KRKELGPLPD DDDMASPKLK LSRKSGISPK
660 670 680 690 700
KSKYMTPMQQ KLNEVYEAVK NYTDKRGRRL SAIFLRLPSR SELPDYYLTI
710 720 730 740 750
KKPMDMEKIR SHMMANKYQD IDSMVEDFVM MFNNACTYNE PESLIYKDAL
760 770 780 790 800
VLHKVLLETR RDLEGDEDSH VPNVTLLIQE LIHNLFVSVM SHQDDEGRCY
810 820 830 840 850
SDSLAEIPAV DPNFPNKPPL TFDIIRKNVE NNRYRRLDLF QEHMFEVLER
860 870 880 890 900
ARRMNRTDSE IYEDAVELQQ FFIKIRDELC KNGEILLSPA LSYTTKHLHN
910 920 930 940 950
DVEKERKEKL PKEIEEDKLK REEEKRAEKS EDSSGAAGLS GLHRTYSQDC
960 970 980 990 1000
SFKNSMYHVG DYVYVEPAEA NLQPHIVCIE RLWEDSAGEK WLYGCWFYRP
1010 1020 1030 1040 1050
NETFHLATRK FLEKEVFKSD YYNKVPVSKI LGKCVVMFVK EYFKLCPENF
1060 1070 1080 1090 1100
RDEDVFVCES RYSAKTKSFK KIKLWTMPIS SVRFVPRDVP LPVVRVASVF
1110 1120 1130 1140 1150
ANADKGDDEK NTDNSEDSRA EDNFNLEKEK EDVPVEMSNG EPGCHYFEQL
1160 1170 1180 1190 1200
HYNDMWLKVG DCVFIKSHGL VRPRVGRIEK VWVRDGAAYF YGPIFIHPEE
1210 1220 1230 1240 1250
TEHEPTKMFY KKEVFLSNLE ETCPMTCILG KCAVLSFKDF LSCRPTEIPE
1260 1270 1280 1290 1300
NDILLCESRY NESDKQMKKF KGLKRFSLSA KVVDDEIYYF RKPIVPQKEP
1310 1320 1330 1340 1350
SPLLEKKIQL LEAKFAELEG GDDDIEEMGE EDSEVIEPPS LPQLQTPLAS
1360 1370 1380 1390 1400
ELDLMPYTPP QSTPKSAKGS AKKEGSKRKI NMSGYILFSS EMRAVIKAQH
1410 1420 1430 1440 1450
PDYSFGELSR LVGTEWRNLE TAKKAEYEGM MGGYPPGLPP LQGPVDGLVS
1460
MGSMQPLHPG
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ86U86 | PB1_HUMAN | Protein polybromo-1 | PBRM1 BAF180, PB1 | 1,689 | Annotation score: | ||
H0Y5B5 | H0Y5B5_HUMAN | Protein polybromo-1 | PBRM1 | 1,085 | Annotation score: | ||
C9JPI5 | C9JPI5_HUMAN | Protein polybromo-1 | PBRM1 | 230 | Annotation score: | ||
C9J053 | C9J053_HUMAN | Protein polybromo-1 | PBRM1 | 118 | Annotation score: | ||
C9JQF1 | C9JQF1_HUMAN | Protein polybromo-1 | PBRM1 | 152 | Annotation score: | ||
C9JCJ2 | C9JCJ2_HUMAN | Protein polybromo-1 | PBRM1 | 87 | Annotation score: | ||
C9J409 | C9J409_HUMAN | Protein polybromo-1 | PBRM1 | 43 | Annotation score: | ||
C9J9L6 | C9J9L6_HUMAN | Protein polybromo-1 | PBRM1 | 26 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1460 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104446 Genomic DNA No translation available. AC112215 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000423351; ENSP00000387775; ENSG00000163939 |
UCSCi | uc062knv.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104446 Genomic DNA No translation available. AC112215 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | E7EVG2 |
PeptideAtlasi | E7EVG2 |
PRIDEi | E7EVG2 |
ProteomicsDBi | 18633 |
Protocols and materials databases
Antibodypediai | 2905, 164 antibodies |
Genome annotation databases
Ensembli | ENST00000423351; ENSP00000387775; ENSG00000163939 |
UCSCi | uc062knv.1, human |
Organism-specific databases
HGNCi | HGNC:30064, PBRM1 |
OpenTargetsi | ENSG00000163939 |
VEuPathDBi | HostDB:ENSG00000163939.18 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000003017 |
Miscellaneous databases
ChiTaRSi | PBRM1, human |
Gene expression databases
Bgeei | ENSG00000163939, Expressed in forebrain and 247 other tissues |
ExpressionAtlasi | E7EVG2, baseline and differential |
Family and domain databases
CDDi | cd05515, Bromo_polybromo_V, 1 hit |
Gene3Di | 1.20.920.10, 6 hits 2.30.30.490, 2 hits |
InterProi | View protein in InterPro IPR001025, BAH_dom IPR043151, BAH_sf IPR001487, Bromodomain IPR036427, Bromodomain-like_sf IPR018359, Bromodomain_CS IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR037968, PBRM1_BD5 IPR037382, Rsc/polybromo |
PANTHERi | PTHR16062, PTHR16062, 2 hits |
Pfami | View protein in Pfam PF01426, BAH, 2 hits PF00439, Bromodomain, 6 hits PF00505, HMG_box, 1 hit |
PRINTSi | PR00503, BROMODOMAIN |
SMARTi | View protein in SMART SM00439, BAH, 2 hits SM00297, BROMO, 6 hits SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit SSF47370, SSF47370, 6 hits |
PROSITEi | View protein in PROSITE PS51038, BAH, 2 hits PS00633, BROMODOMAIN_1, 5 hits PS50014, BROMODOMAIN_2, 6 hits PS50118, HMG_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7EVG2_HUMAN | |
Accessioni | E7EVG2Primary (citable) accession number: E7EVG2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | October 5, 2016 | |
Last modified: | February 10, 2021 | |
This is version 76 of the entry and version 8 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |