UniProtKB - E7EV99 (E7EV99_HUMAN)
Protein
Submitted name:
Alpha-adducin
Gene
ADD1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Alpha-adducinImported |
Gene namesi | Name:ADD1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000087274.16 |
HGNCi | HGNC:243, ADD1 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Source: InterPro
PTM / Processingi
Proteomic databases
MaxQBi | E7EV99 |
PeptideAtlasi | E7EV99 |
PRIDEi | E7EV99 |
ProteomicsDBi | 18593 |
Expressioni
Gene expression databases
Bgeei | ENSG00000087274, Expressed in primary visual cortex and 248 other tissues |
ExpressionAtlasi | E7EV99, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 147 – 329 | Aldolase_IIInterPro annotationAdd BLAST | 183 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 421 – 487 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 576 – 632 | DisorderedSequence analysisAdd BLAST | 57 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 421 – 436 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 437 – 453 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 576 – 602 | PolyampholyteSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000158581 |
Family and domain databases
Gene3Di | 3.40.225.10, 1 hit |
InterProi | View protein in InterPro IPR027766, ADD1 IPR001303, Aldolase_II/adducin_N IPR036409, Aldolase_II/adducin_N_sf |
PANTHERi | PTHR10672:SF4, PTHR10672:SF4, 1 hit |
Pfami | View protein in Pfam PF00596, Aldolase_II, 1 hit |
SMARTi | View protein in SMART SM01007, Aldolase_II, 1 hit |
SUPFAMi | SSF53639, SSF53639, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
E7EV99-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN
60 70 80 90 100
MMEQKKRVSM ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT
110 120 130 140 150
NVPNVYPAAP QGGMAALNMS LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA
160 170 180 190 200
AFYRLADLFG WSQLIYNHIT TRVNSEQEHF LIVPFGLLYS EVTASSLVKI
210 220 230 240 250
NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI HTPAGAAVSA
260 270 280 290 300
MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR
310 320 330 340 350
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK
360 370 380 390 400
AKSRSPGSPV GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL
410 420 430 440 450
REKSKKYSDV EVPASVTGYS FASDGDSGTC SPLRHSFQKQ QREKTRWLNS
460 470 480 490 500
GRGDEASEEG QNGSSPKSKT KWTKEDGHRT STSAVPNLFV PLNTNPKEVQ
510 520 530 540 550
EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT ASKAIIEKEY
560 570 580 590 600
QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS
610 620 630
PPDQPAVPHP PPSTPIKLEE AGDGCAREYL LP
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP35611 | ADDA_HUMAN | Alpha-adducin | ADD1 ADDA | 737 | Annotation score: | ||
H0Y9H2 | H0Y9H2_HUMAN | Alpha-adducin | ADD1 | 444 | Annotation score: | ||
E7ENY0 | E7ENY0_HUMAN | Alpha-adducin | ADD1 | 663 | Annotation score: | ||
D6RF25 | D6RF25_HUMAN | Alpha-adducin | ADD1 | 142 | Annotation score: | ||
A0A0A0MSR2 | A0A0A0MSR2_HUMAN | Alpha-adducin | ADD1 | 400 | Annotation score: | ||
H0YG19 | H0YG19_HUMAN | Alpha-adducin | ADD1 | 114 | Annotation score: | ||
D6RAH3 | D6RAH3_HUMAN | Alpha-adducin | ADD1 | 137 | Annotation score: | ||
D6RJE2 | D6RJE2_HUMAN | Alpha-adducin | ADD1 | 69 | Annotation score: | ||
H0YFD8 | H0YFD8_HUMAN | Alpha-adducin | ADD1 | 105 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121750 Genomic DNA No translation available. AL390065 Genomic DNA No translation available. BX465861 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000513328; ENSP00000421907; ENSG00000087274 |
UCSCi | uc062ury.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121750 Genomic DNA No translation available. AL390065 Genomic DNA No translation available. BX465861 Genomic DNA No translation available. |
3D structure databases
SMRi | E7EV99 |
ModBasei | Search... |
Proteomic databases
MaxQBi | E7EV99 |
PeptideAtlasi | E7EV99 |
PRIDEi | E7EV99 |
ProteomicsDBi | 18593 |
Protocols and materials databases
Antibodypediai | 4065, 739 antibodies |
Genome annotation databases
Ensembli | ENST00000513328; ENSP00000421907; ENSG00000087274 |
UCSCi | uc062ury.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000087274.16 |
HGNCi | HGNC:243, ADD1 |
OpenTargetsi | ENSG00000087274 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158581 |
Miscellaneous databases
ChiTaRSi | ADD1, human |
Gene expression databases
Bgeei | ENSG00000087274, Expressed in primary visual cortex and 248 other tissues |
ExpressionAtlasi | E7EV99, baseline and differential |
Family and domain databases
Gene3Di | 3.40.225.10, 1 hit |
InterProi | View protein in InterPro IPR027766, ADD1 IPR001303, Aldolase_II/adducin_N IPR036409, Aldolase_II/adducin_N_sf |
PANTHERi | PTHR10672:SF4, PTHR10672:SF4, 1 hit |
Pfami | View protein in Pfam PF00596, Aldolase_II, 1 hit |
SMARTi | View protein in SMART SM01007, Aldolase_II, 1 hit |
SUPFAMi | SSF53639, SSF53639, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7EV99_HUMAN | |
Accessioni | E7EV99Primary (citable) accession number: E7EV99 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | August 12, 2020 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |