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Protein
Submitted name:

Cytoplasmic dynein 1 intermediate chain 2

Gene

DYNC1I2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Cytoplasmic dynein 1 intermediate chain 2Imported
Gene namesi
Name:DYNC1I2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000077380.15
HGNCiHGNC:2964 DYNC1I2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000077380

PTM / Processingi

Proteomic databases

PeptideAtlasiE7EV09
PRIDEiE7EV09

Expressioni

Gene expression databases

BgeeiENSG00000077380 Expressed in 93 organ(s), highest expression level in corpus callosum
ExpressionAtlasiE7EV09 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE7EV09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 41Sequence analysisAdd BLAST41

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1587 Eukaryota
ENOG410XQ99 LUCA
GeneTreeiENSGT00730000110228

Family and domain databases

InterProiView protein in InterPro
IPR025956 DYNC1I1/DYNC1I2
PfamiView protein in Pfam
PF11540 Dynein_IC2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

E7EV09-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAVAPVQEE
60 70 80 90 100
SDLEKKRREA EALLQSMGLT PESPIVPPPM SPSSKSVSTP SEAGSQDSGD
110 120 130 140 150
GAVGSRTLHW DTDPSVLQLH SDSDLGRGPI KLGMAKITQV DFPPREIVTY
160 170 180 190 200
TKETQTPVMA QPKEDEEEDD DVVAPKPPIE PEEEKTLKKD EENDSKAPPH
210 220 230 240 250
ELTEEEKQQI LHSEEFLSFF DHSTRIVERA LSEQINIFFD YSGRDLEDKE
Length:250
Mass (Da):28,405
Last modified:October 5, 2016 - v8
Checksum:i9553753D13C9C337
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q13409DC1I2_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2 DNCI2, DNCIC2
638Annotation score:
E7ETL8E7ETL8_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
184Annotation score:
E7EQU2E7EQU2_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
185Annotation score:
E7EMU4E7EMU4_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
214Annotation score:
E7ESD3E7ESD3_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
187Annotation score:
E7EQL5E7EQL5_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
305Annotation score:
E7ET01E7ET01_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
173Annotation score:
E7EU01E7EU01_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
121Annotation score:
E7ERR6E7ERR6_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
139Annotation score:
E9PGG1E9PGG1_HUMAN
Cytoplasmic dynein 1 intermediate c...
DYNC1I2
110Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei250Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC064826 Genomic DNA No translation available.
AC068039 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000452242; ENSP00000398765; ENSG00000077380
UCSCiuc061ppu.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC064826 Genomic DNA No translation available.
AC068039 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE7EV09
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiE7EV09
PRIDEiE7EV09

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000452242; ENSP00000398765; ENSG00000077380
UCSCiuc061ppu.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000077380.15
HGNCiHGNC:2964 DYNC1I2
OpenTargetsiENSG00000077380
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1587 Eukaryota
ENOG410XQ99 LUCA
GeneTreeiENSGT00730000110228

Miscellaneous databases

ChiTaRSiDYNC1I2 human

Gene expression databases

BgeeiENSG00000077380 Expressed in 93 organ(s), highest expression level in corpus callosum
ExpressionAtlasiE7EV09 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR025956 DYNC1I1/DYNC1I2
PfamiView protein in Pfam
PF11540 Dynein_IC2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE7EV09_HUMAN
AccessioniPrimary (citable) accession number: E7EV09
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 55 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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