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Entry version 74 (29 Sep 2021)
Sequence version 3 (02 Dec 2020)
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Protein
Submitted name:

Rho guanine nucleotide exchange factor 4

Gene

ARHGEF4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGEF4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:684, ARHGEF4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000136002

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000136002

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
E7EV07

PRoteomics IDEntifications database

More...
PRIDEi
E7EV07

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
18543

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
E7EV07

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136002, Expressed in right frontal lobe and 196 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7EV07, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E7EV07

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1380 – 1439SH3InterPro annotationAdd BLAST60
Domaini1470 – 1654DHInterPro annotationAdd BLAST185
Domaini1685 – 1792PHInterPro annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni14 – 85DisorderedSequence analysisAdd BLAST72
Regioni362 – 386DisorderedSequence analysisAdd BLAST25
Regioni452 – 488DisorderedSequence analysisAdd BLAST37
Regioni512 – 536DisorderedSequence analysisAdd BLAST25
Regioni596 – 625DisorderedSequence analysisAdd BLAST30
Regioni638 – 702DisorderedSequence analysisAdd BLAST65
Regioni718 – 898DisorderedSequence analysisAdd BLAST181
Regioni925 – 992DisorderedSequence analysisAdd BLAST68
Regioni1086 – 1109DisorderedSequence analysisAdd BLAST24
Regioni1153 – 1201DisorderedSequence analysisAdd BLAST49
Regioni1299 – 1331DisorderedSequence analysisAdd BLAST33
Regioni1443 – 1468DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi32 – 80Polar residuesSequence analysisAdd BLAST49
Compositional biasi452 – 466Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi522 – 536Polar residuesSequence analysisAdd BLAST15
Compositional biasi729 – 749Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi925 – 950Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1299 – 1316Polar residuesSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164741

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002250_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERETQKH

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit
PF00018, SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

E7EV07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSVVHFLRS FFKTPEPGAH LPGEGEIEDN QLPTSPAEQV EQGWNQQTDR
60 70 80 90 100
DDSETLSQQS ESGSDTKTDP FESASDTESL SGYLPRGVFH PLRGTPVDIE
110 120 130 140 150
APWEYPDVSA TGPPQEQHLT SVPGLHAKEE LDLSPSLEDD SCKNGWRAFA
160 170 180 190 200
TVAGEQEAGH LWDCATSLER ESLLAGVPRH TGCCLQRATD SSGPEPVQGV
210 220 230 240 250
AVQDLRGLSS VSLQKSRSES YLGIPVVWPF LLWCCELGRS WPHIHNRARA
260 270 280 290 300
LVLPSRGPLD NTAPLGTRTK KESTLGPAGD TELLWSQPHS DVPCQPPLRT
310 320 330 340 350
SCLLRTNRHH SAPETTGDKN RASPRLNCGH MRALVRAHSI AGFSPECPED
360 370 380 390 400
PVGQNVVKSG THVKEGAKNE RDPRIQNIPS PAPTQLSGPI PAFQSGAPHL
410 420 430 440 450
QGPCKPGGFR LQRASQDTPS AGLLGENQLR QDSRSCLVAS CLTSELVKLS
460 470 480 490 500
AEEVPEPAEC KSEQSPESRT QEPQGTQLAP RAADERETQK HLWGISVQAG
510 520 530 540 550
NQTSNYTSKY VLSEESKSPT RAKFPRQPSS EGTQVWSGDL MGCLEVSDSS
560 570 580 590 600
DAPETTQKSS AIDTSKAAEE AMVLDPNYRE QALQGLSEFK AATVSHCGPG
610 620 630 640 650
AEEGEQGPGG AGGRQLEPKA GGEASRGRGA LIIVAVEQKG LQASRSNAGP
660 670 680 690 700
VPETLPRDFP KERPESPLST GETPCESPTR GKTPAGNECE LPAAPIQGAG
710 720 730 740 750
DGALQRVAQA AELGRVLVPQ AASEETPSTE EPPGERLRGE SRSSGSGERG
760 770 780 790 800
PEEAPEGGAA AARGQRPRVP ALEPPQPPRG LRKGAQEPGK RPTFSKVTSF
810 820 830 840 850
RKGRPLATES PGGVPAPTTE GRRWGSSGPE GLPRENPPAA AGRDAPPLHH
860 870 880 890 900
GDASAWPEFV PQAAGDRTAG PAGAGHTGTS GDLGSRGPSS ESCNAKRLKT
910 920 930 940 950
TEKKLRARLA LAHKTFSNFI ESIVLEKENT HERSPSSPKG EKEKSRLRQG
960 970 980 990 1000
SWRAFLKSKD AGSPKKPTLV SLPLGPEVLS PAETDSHCEE RAEDKEGYVF
1010 1020 1030 1040 1050
SDHWAPPLAS TPLSSSLVSP EHRRKSEPTI KCTATQEGGR YLPSGIFPEK
1060 1070 1080 1090 1100
SWLASPGSPR AQQAGIAHTL PSSSACCLAY ENPGTPCRPT SPKPLSPRPS
1110 1120 1130 1140 1150
AQRMGLHYPG RGSAISMVSL GSYSYVDSSS GDPERPKIPK GQTSFLLSLQ
1160 1170 1180 1190 1200
TLNQDEQKEE SREGGQGPRG LGTVPWLRDL PGSENHMPWE EPAGEKPSCS
1210 1220 1230 1240 1250
HSQKAFHMEP AQKPCFTTDM VTWALLCISA ETVRGEAPSQ PRGIPHRSPV
1260 1270 1280 1290 1300
SVDDLWLEKT QRKKLQKQAH VERRLHIGAV HKDGVKCWRK TIITSPESLN
1310 1320 1330 1340 1350
LPRRSHPLSQ SAPTGLNHMG WPEHTPGTAM PDGALDTAVC ADEVGSEEDL
1360 1370 1380 1390 1400
YDDLHSSSHH YSHPGGGGEQ LAINELISDG SVVCAEALWD HVTMDDQELG
1410 1420 1430 1440 1450
FKAGDVIEVM DATNREWWWG RVADGEGWFP ASFVRLRVNQ DEPADDDAPL
1460 1470 1480 1490 1500
AGNSGAEDGG AEAQSSKDQM RTNVINEILS TERDYIKHLR DICEGYVRQC
1510 1520 1530 1540 1550
RKRADMFSEE QLRTIFGNIE DIYRCQKAFV KALEQRFNRE RPHLSELGAC
1560 1570 1580 1590 1600
FLEHQADFQI YSEYCNNHPN ACVELSRLTK LSKYVYFFEA CRLLQKMIDI
1610 1620 1630 1640 1650
SLDGFLLTPV QKICKYPLQL AELLKYTHPQ HRDFKDVEAA LHAMKNVAQL
1660 1670 1680 1690 1700
INERKRRLEN IDKIAQWQSS IEDWEGEDLL VRSSELIYSG ELTRVTQPQA
1710 1720 1730 1740 1750
KSQQRMFFLF DHQLIYCKKD LLRRDVLYYK GRLDMDGLEV VDLEDGKDRD
1760 1770 1780 1790 1800
LHVSIKNAFR LHRGATGDSH LLCTRKPEQK QRWLKAFARE REQVQLDQET
1810 1820 1830 1840 1850
GFSITELQRK QAMLNASKQQ VTGKPKAVGR PCYLTRQKHP ALPSNRPQQQ
1860 1870
VLVLAEPRRK PSTFWHSISR LAPFRK
Length:1,876
Mass (Da):205,471
Last modified:December 2, 2020 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0402AC0E8B687FE7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9NR80ARHG4_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF4 KIAA1112
690Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCT6H0YCT6_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF4
287Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0P1A0A087X0P1_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF4
630Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DFY6A0A0C4DFY6_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF4
695Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PEM0E9PEM0_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF4
517Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GW00A0A1B0GW00_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF4
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y451H0Y451_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF4
372Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A4QPB6A4QPB6_HUMAN
ARHGEF4 protein
ARHGEF4
192Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC009477 Genomic DNA No translation available.
AC112786 Genomic DNA No translation available.
AC133785 Genomic DNA No translation available.
KF456708 Genomic DNA No translation available.
KF456713 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005263738.1, XM_005263681.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000409359; ENSP00000386794; ENSG00000136002

UCSC genome browser

More...
UCSCi
uc002trz.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009477 Genomic DNA No translation available.
AC112786 Genomic DNA No translation available.
AC133785 Genomic DNA No translation available.
KF456708 Genomic DNA No translation available.
KF456713 Genomic DNA No translation available.
RefSeqiXP_005263738.1, XM_005263681.1

3D structure databases

SMRiE7EV07
ModBaseiSearch...

PTM databases

iPTMnetiE7EV07

Proteomic databases

PeptideAtlasiE7EV07
PRIDEiE7EV07
ProteomicsDBi18543

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18611, 183 antibodies

Genome annotation databases

EnsembliENST00000409359; ENSP00000386794; ENSG00000136002
UCSCiuc002trz.2, human

Organism-specific databases

HGNCiHGNC:684, ARHGEF4
OpenTargetsiENSG00000136002
VEuPathDBiHostDB:ENSG00000136002

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000164741
HOGENOMiCLU_002250_0_0_1
OMAiERETQKH

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARHGEF4, human

Gene expression databases

BgeeiENSG00000136002, Expressed in right frontal lobe and 196 other tissues
ExpressionAtlasiE7EV07, baseline and differential

Family and domain databases

CDDicd00160, RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR001331, GDS_CDC24_CS
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF00621, RhoGEF, 1 hit
PF00018, SH3_1, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00325, RhoGEF, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00741, DH_1, 1 hit
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7EV07_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7EV07
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: December 2, 2020
Last modified: September 29, 2021
This is version 74 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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