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Protein

Peroxisome proliferator-activated receptor gamma

Gene

PPARG

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, DNA-bindingUniRule annotation, ReceptorUniRule annotation
Biological processBiological rhythmsUniRule annotation, Transcription, Transcription regulationUniRule annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gammaUniRule annotation
Short name:
PPAR-gammaUniRule annotation
Alternative name(s):
Nuclear receptor subfamily 1 group C member 3UniRule annotation
Gene namesi
Name:PPARGUniRule annotationImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000132170.19
HGNCiHGNC:9236 PPARG

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132170

PTM / Processingi

Proteomic databases

MaxQBiE7EUD1
PeptideAtlasiE7EUD1
PRIDEiE7EUD1

Expressioni

Gene expression databases

BgeeiENSG00000132170 Expressed in 136 organ(s), highest expression level in subcutaneous adipose tissue
ExpressionAtlasiE7EUD1 baseline and differential

Interactioni

Subunit structurei

Heterodimer with other nuclear receptors.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE7EUD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 132Nuclear receptorInterPro annotationAdd BLAST25

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR1 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136388

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003077 PPAR-gamma
IPR022590 PPARgamma_N
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF12577 PPARgamma_N, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01291 PROXISOMPAGR
PR00047 STROIDFINGER
PROSITEiView protein in PROSITE
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

E7EUD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMVDTEMPF WPTNFGISSV DLSVMEDHSH SFDIKPFTTV DFSSISTPHY
60 70 80 90 100
EDIPFTRTDP VVADYKYDLK LQEYQSAIKV EPASPPYYSE KTQLYNKPHE
110 120 130
EPSNSLMAIE CRVCGDKASG FHYGVHACEG CK
Length:132
Mass (Da):14,984
Last modified:March 8, 2011 - v1
Checksum:i43B20D2711C58FBA
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P37231PPARG_HUMAN
Peroxisome proliferator-activated r...
PPARG NR1C3
505Annotation score:
E9PFV2E9PFV2_HUMAN
Peroxisome proliferator-activated r...
PPARG
483Annotation score:
E9PFX5E9PFX5_HUMAN
Peroxisome proliferator-activated r...
PPARG
250Annotation score:
E7EU07E7EU07_HUMAN
Peroxisome proliferator-activated r...
PPARG
99Annotation score:
E9PFJ1E9PFJ1_HUMAN
Peroxisome proliferator-activated r...
PPARG
43Annotation score:
E9PFV3E9PFV3_HUMAN
Peroxisome proliferator-activated r...
PPARG
40Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei132Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090947 Genomic DNA No translation available.
AC091492 Genomic DNA No translation available.
AC093174 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000397029; ENSP00000380224; ENSG00000132170
UCSCiuc062gux.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090947 Genomic DNA No translation available.
AC091492 Genomic DNA No translation available.
AC093174 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliE7EUD1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiE7EUD1
PeptideAtlasiE7EUD1
PRIDEiE7EUD1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397029; ENSP00000380224; ENSG00000132170
UCSCiuc062gux.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000132170.19
HGNCiHGNC:9236 PPARG
OpenTargetsiENSG00000132170
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136388

Miscellaneous databases

ChiTaRSiPPARG human

Gene expression databases

BgeeiENSG00000132170 Expressed in 136 organ(s), highest expression level in subcutaneous adipose tissue
ExpressionAtlasiE7EUD1 baseline and differential

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003077 PPAR-gamma
IPR022590 PPARgamma_N
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF12577 PPARgamma_N, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01291 PROXISOMPAGR
PR00047 STROIDFINGER
PROSITEiView protein in PROSITE
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiE7EUD1_HUMAN
AccessioniPrimary (citable) accession number: E7EUD1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: November 7, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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