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Entry version 74 (29 Sep 2021)
Sequence version 1 (08 Mar 2011)
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Protein

C3/C5 convertase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b.ARBA annotation EC:3.4.21.47

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationARBA annotation
Biological processComplement alternate pathwayARBA annotation, Immunity, Innate immunity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C3/C5 convertaseARBA annotation (EC:3.4.21.47ARBA annotation)
Alternative name(s):
Complement factor BARBA annotation
Complement factor B Ba fragmentARBA annotation
Complement factor B Bb fragmentARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000244255

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ENSG00000244255

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500321949121 – 1115C3/C5 convertaseSequence analysisAdd BLAST1095

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi117 ↔ 144PROSITE-ProRule annotation
Disulfide bondi482 ↔ 509PROSITE-ProRule annotation
Disulfide bondi542 ↔ 569PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, ZymogenARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
E7ETN3

PeptideAtlas

More...
PeptideAtlasi
E7ETN3

PRoteomics IDEntifications database

More...
PRIDEi
E7ETN3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
18248

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000244255, Expressed in liver and 86 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
E7ETN3, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
E7ETN3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 86SushiInterPro annotationAdd BLAST65
Domaini87 – 146SushiInterPro annotationAdd BLAST60
Domaini235 – 691Peptidase S1InterPro annotationAdd BLAST457
Domaini452 – 511SushiInterPro annotationAdd BLAST60
Domaini514 – 571SushiInterPro annotationAdd BLAST58
Domaini621 – 820VWFAInterPro annotationAdd BLAST200
Domaini828 – 1108Peptidase S1InterPro annotationAdd BLAST281

Keywords - Domaini

SignalSequence analysis, SushiPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158605

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 3 hits
cd00190, Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011360, Compl_C2_B
IPR028341, Complement_B
IPR009003, Peptidase_S1_PA
IPR001314, Peptidase_S1A
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR46393, PTHR46393, 6 hits
PTHR46393:SF1, PTHR46393:SF1, 6 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084, Sushi, 3 hits
PF00089, Trypsin, 2 hits
PF00092, VWA, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00722, CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 4 hits
SM00020, Tryp_SPc, 2 hits
SM00327, VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 2 hits
SSF53300, SSF53300, 2 hits
SSF57535, SSF57535, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923, SUSHI, 4 hits
PS50240, TRYPSIN_DOM, 2 hits
PS00134, TRYPSIN_HIS, 2 hits
PS00135, TRYPSIN_SER, 1 hit
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

E7ETN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPLMVLFCL LFLYPGLADS APSCPQNVNI SGGTFTLSHG WAPGSLLTYS
60 70 80 90 100
CPQGLYPSPA SRLCKSSGQW QTPGATRSLS KAVCKPVRCP APVSFENGIY
110 120 130 140 150
TPRLGSYPVG GNVSFECEDG FILRGSPVRQ CRPNGMWDGE TAVCDNGDHE
160 170 180 190 200
NGTGTNTYAA LNSVYLMMNN QMRLLGMETM AWQEIRHAII LLTDGKSNMG
210 220 230 240 250
GSPKTAVDHI REILNINQKR NDYLDVSKLT DTICGVGNMS ANASDQERTP
260 270 280 290 300
WHVTIKPKSQ ETCRGALISD QWVLTAAHCF RDGNDHSLWR VNVGDPKSQW
310 320 330 340 350
GKEFLIEKAV ISPGFDVFAK KNQGILEFYG DDIALLKLAQ KVKMSTHARP
360 370 380 390 400
ICLPCTMEAN LALRRPQGST CRDHENELLN KQSVPAHFVA LNGSKLNINL
410 420 430 440 450
KMGVEWTSCA EVVSQEKTMF PNLTDVREVV TDQFLCSGTQ EDESPCKGGS
460 470 480 490 500
AIHCPRPHDF ENGEYWPRSP YYNVSDEISF HCYDGYTLRG SANRTCQVNG
510 520 530 540 550
RWSGQTAICD NGAGYCSNPG IPIGTRKVGS QYRLEDSVTY HCSRGLTLRG
560 570 580 590 600
SQRRTCQEGG SWSGTEPSCQ DSFMYDTPQE VAEAFLSSLT ETIEGVDAED
610 620 630 640 650
GHGPGEQQKR KIVLDPSGSM NIYLVLDGSD SIGASNFTGA KKCLVNLIEK
660 670 680 690 700
VASYGVKPRY GLVTYATYPK IWVKVSEADS SNADWVTKQL NEINYEDHKL
710 720 730 740 750
KSGTNTKKAL QAVYSMMSWP DDVPPEGWNR TRHVIILMTD GLHNMGGDPI
760 770 780 790 800
TVIDEIRDLL YIGKDRKNPR EDYLDVYVFG VGPLVNQVNI NALASKKDNE
810 820 830 840 850
QHVFKVKDME NLEDVFYQMI DESQSLSLCG MVWEHRKGTD YHKQPWQAKI
860 870 880 890 900
SVIRPSKGHE SCMGAVVSEY FVLTAAHCFT VDDKEHSIKV SVGGEKRDLE
910 920 930 940 950
IEVVLFHPNY NINGKKEAGI PEFYDYDVAL IKLKNKLKYG QTIRPICLPC
960 970 980 990 1000
TEGTTRALRL PPTTTCQQQK EELLPAQDIK ALFVSEEEKK LTRKEVYIKN
1010 1020 1030 1040 1050
GDKKGSCERD AQYAPGYDKV KDISEVVTPR FLCTGGVSPY ADPNTCRGDS
1060 1070 1080 1090 1100
GGPLIVHKRS RFIQVGVISW GVVDVCKNQK RQKQVPAHAR DFHINLFQVL
1110
PWLKEKLQDE DLGFL
Length:1,115
Mass (Da):124,017
Last modified:March 8, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC98F353FDB37F25B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL645922 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000477310; ENSP00000418996; ENSG00000244255

UCSC genome browser

More...
UCSCi
uc063nji.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645922 Genomic DNA No translation available.

3D structure databases

SMRiE7ETN3
ModBaseiSearch...

Genetic variation databases

BioMutaiENSG00000244255

Proteomic databases

MaxQBiE7ETN3
PeptideAtlasiE7ETN3
PRIDEiE7ETN3
ProteomicsDBi18248

Genome annotation databases

EnsembliENST00000477310; ENSP00000418996; ENSG00000244255
UCSCiuc063nji.1, human

Organism-specific databases

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ENSG00000244255
VEuPathDBiHostDB:ENSG00000244255

Phylogenomic databases

GeneTreeiENSGT00940000158605

Gene expression databases

BgeeiENSG00000244255, Expressed in liver and 86 other tissues
ExpressionAtlasiE7ETN3, baseline and differential

Family and domain databases

CDDicd00033, CCP, 3 hits
cd00190, Tryp_SPc, 1 hit
Gene3Di3.40.50.410, 2 hits
InterProiView protein in InterPro
IPR011360, Compl_C2_B
IPR028341, Complement_B
IPR009003, Peptidase_S1_PA
IPR001314, Peptidase_S1A
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PANTHERiPTHR46393, PTHR46393, 6 hits
PTHR46393:SF1, PTHR46393:SF1, 6 hits
PfamiView protein in Pfam
PF00084, Sushi, 3 hits
PF00089, Trypsin, 2 hits
PF00092, VWA, 2 hits
PRINTSiPR00722, CHYMOTRYPSIN
SMARTiView protein in SMART
SM00032, CCP, 4 hits
SM00020, Tryp_SPc, 2 hits
SM00327, VWA, 1 hit
SUPFAMiSSF50494, SSF50494, 2 hits
SSF53300, SSF53300, 2 hits
SSF57535, SSF57535, 4 hits
PROSITEiView protein in PROSITE
PS50923, SUSHI, 4 hits
PS50240, TRYPSIN_DOM, 2 hits
PS00134, TRYPSIN_HIS, 2 hits
PS00135, TRYPSIN_SER, 1 hit
PS50234, VWFA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE7ETN3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: E7ETN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 29, 2021
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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