UniProtKB - E7ETN2 (E7ETN2_HUMAN)
Protein
Eyes absent homolog
Gene
EYA2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphateUniRule annotationARBA annotationEC:3.1.3.48UniRule annotationARBA annotation
Cofactori
Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 274 | NucleophileUniRule annotation | 1 | |
Metal bindingi | 274 | MagnesiumUniRule annotation | 1 | |
Active sitei | 276 | Proton donorUniRule annotation | 1 | |
Metal bindingi | 276 | Magnesium; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 472 | MagnesiumUniRule annotation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- protein tyrosine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- DNA repair Source: UniProtKB-KW
- multicellular organism development Source: UniProtKB-KW
- striated muscle tissue development Source: InterPro
Keywordsi
Molecular function | Developmental proteinARBA annotation, Hydrolase, Protein phosphataseUniRule annotationARBA annotation |
Biological process | DNA damage, DNA repairARBA annotation, Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | MagnesiumUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:EYA2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000064655.18 |
HGNCi | HGNC:3520, EYA2 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000064655, Expressed in calcaneal tendon and 167 other tissues |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 209 – 263 | DisorderedSequence analysisAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 209 – 232 | PolarSequence analysisAdd BLAST | 24 | |
Compositional biasi | 233 – 262 | PolyampholyteSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00950000182978 |
Family and domain databases
CDDi | cd02601, HAD_Eya, 1 hit |
Gene3Di | 3.40.50.12350, 1 hit |
InterProi | View protein in InterPro IPR028473, EYA2 IPR006545, EYA_dom IPR042577, EYA_dom_metazoan IPR038102, EYA_dom_sf IPR028472, EYA_fam IPR036412, HAD-like_sf |
PANTHERi | PTHR10190, PTHR10190, 2 hits PTHR10190:SF7, PTHR10190:SF7, 2 hits |
SUPFAMi | SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR01658, EYA-cons_domain, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
E7ETN2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF
60 70 80 90 100
SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS
110 120 130 140 150
IKTEDSLNHS PGQSGFLSYG SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL
160 170 180 190 200
GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS SYNPPYVPAS SICPSPLSTS
210 220 230 240 250
TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR PHRASDGKLR
260 270 280 290 300
GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDCDQ
310 320 330 340 350
IHVDDVSSDD NGQDLSTYNF SADGFHSSAP GANLCLGSGV HGGVDWMRKL
360 370 380 390 400
AFRYRRVKEM YNTYKNNVGG LIGTPKRETW LQLRAELEAL TDLWLTHSLK
410 420 430 440 450
ALNLINSRPN CVNVLVTTTQ LIPALAKVLL YGLGSVFPIE NIYSATKTGK
460 470 480 490 500
ESCFERIMQR FGRKAVYVVI GDGVEEEQGA KKHNMPFWRI SCHADLEALR
HALELEYL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO00167 | EYA2_HUMAN | Eyes absent homolog 2 | EYA2 EAB1 | 538 | Annotation score: | ||
B1AKW3 | B1AKW3_HUMAN | Eyes absent homolog | EYA2 | 197 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL022342 Genomic DNA No translation available. AL121776 Genomic DNA No translation available. AL354766 Genomic DNA No translation available. AL359434 Genomic DNA No translation available. KF456925 Genomic DNA No translation available. KF456926 Genomic DNA No translation available. |
RefSeqi | XP_016883210.1, XM_017027721.1 |
Genome annotation databases
Ensembli | ENST00000317304; ENSP00000321590; ENSG00000064655 ENST00000611592; ENSP00000483392; ENSG00000064655 |
GeneIDi | 2139 |
UCSCi | uc002xsq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL022342 Genomic DNA No translation available. AL121776 Genomic DNA No translation available. AL354766 Genomic DNA No translation available. AL359434 Genomic DNA No translation available. KF456925 Genomic DNA No translation available. KF456926 Genomic DNA No translation available. |
RefSeqi | XP_016883210.1, XM_017027721.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 18247 |
Protocols and materials databases
Antibodypediai | 13258, 256 antibodies |
Genome annotation databases
Ensembli | ENST00000317304; ENSP00000321590; ENSG00000064655 ENST00000611592; ENSP00000483392; ENSG00000064655 |
GeneIDi | 2139 |
UCSCi | uc002xsq.4, human |
Organism-specific databases
CTDi | 2139 |
EuPathDBi | HostDB:ENSG00000064655.18 |
HGNCi | HGNC:3520, EYA2 |
OpenTargetsi | ENSG00000064655 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182978 |
Miscellaneous databases
BioGRID-ORCSi | 2139, 3 hits in 848 CRISPR screens |
ChiTaRSi | EYA2, human |
GenomeRNAii | 2139 |
Gene expression databases
Bgeei | ENSG00000064655, Expressed in calcaneal tendon and 167 other tissues |
Family and domain databases
CDDi | cd02601, HAD_Eya, 1 hit |
Gene3Di | 3.40.50.12350, 1 hit |
InterProi | View protein in InterPro IPR028473, EYA2 IPR006545, EYA_dom IPR042577, EYA_dom_metazoan IPR038102, EYA_dom_sf IPR028472, EYA_fam IPR036412, HAD-like_sf |
PANTHERi | PTHR10190, PTHR10190, 2 hits PTHR10190:SF7, PTHR10190:SF7, 2 hits |
SUPFAMi | SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR01658, EYA-cons_domain, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | E7ETN2_HUMAN | |
Accessioni | E7ETN2Primary (citable) accession number: E7ETN2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 8, 2011 |
Last sequence update: | March 8, 2011 | |
Last modified: | December 2, 2020 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |